Hancock HC, Maier R, Kasim AS, Goodwin A, Owens WA, Mason JM, Murphy GJ, Kirmani B, Akowuah EA. Mini-sternotomy versus conventional sternotomy for aortic valve replacement: results from the MAVRIC randomised controlled trial. Journal of the American College of Cardiology (JACC). 2019; 73(19): 2487-2492

Yiannakou Y, Etherson K, Close H, Kasim A, Mercer-Jones M, Plusa S, Maier R, Green S, Cundall S, Knowles C and Mason J. A randomised double-blinded Sham-controlled cross-over trial of tined-lead sacral nerve stimulation testing for chronic constipation. European Journal of Gastroenterology & Hepatology 2019;31(6): 653-660. DOI: 19.1097/MEG.0000000000001379.

Aspray TJ, Chadwick T, Francis RM, McColl E, Stamp E, Prentice A, von Wilamowitz-Moellendorff A, Scoenmakers I. Randomized controlled trial of Vitamin D supplementation in older people to optimize bone health. American Journal of Clinical Nutrition 2019;109(1): 207-217

Cole M, Hynes AM, Howel D, Hall L, Abinum M, Allahabadia A, Barrett T, Boelaert K, Drake AJ, Dimitri P, Kirk J, Zammitt N, Pearce S, Cheetman T. Adjuvant rituximab, a potential treatment for the young patient with Graves' hyperthyroidism (RiGD): Study protocol for a single-arm, single-stage, phase II trial. BMJ Open 2019; 9 (1), e024705

Adams N, Skelton D, Bailey C, Howel D, Coe D, Lampitt R, Wilkinson J, Fouweather T, de John LD, Gawler S, Deary V, Gray J, Waterman H, Parry SW. Visually Impaired Older people's Exercise programme for falls prevenTion (VIOLET): a feasibility study. NIHR Journals Library 2019 https://www.journalslibrary.nihr.ac.uk/phr/phr07040/

Price CI, Shaw L, Dodd P, Exley C, Plynmn D, Francis R, Islam S, Javanbakht M, Lakey R, Lally J, McClelland G, McMeekin P, Rodgers H, Snooks H, Sutcliffe L, Tyrell P, Vale L, Watkins A, Ford GA. Paramedic Acute Stroke Treatment Assessment (PASTA): Study protocol for a randomised controlled trial. BioMed Central Ltd. 2019;20(1), [121]
https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-018-3144-z

Dutta P, Funaton W, Mossop H, Ryan V, Jones R, Forbes R, Sen S, Pearson J, Griffin SM, Smith JA, Ward C, Forrest IA, Simpson AJ. Randomised, double-blind, placebo-controlled pilot trial of omeprazole in idiopathic pulmonary fibrosis. Thorax 2019. http://thorax.bmj.com/cgi/content/full/thoraxjnl-2018-212102

Giles EL, McGeechan GJ, Coulton S, Deluca P, Drummond C, Howel D, Kaner E, McColl E, McGovern R, Scott S, Stamp E, Sumnall T, Todd L, Vale L, Albani V, Boniface S, Ferguson J, Gilvarry E, Hendrie N, Howe N, Mossop H, Ramsay A, Stanley G, Newbury-Birch D. Brief alcohol intervention for risky drinking in young people aged 14 15 years in secondary schools: the SIPS JR-HIGH RCT. Brief alcohol intervention for risky drinking in young people aged 14 15 years in secondary schools: the SIPS JR-HIGH RCT. Public Health Research 2019; 9 https://doi.org/10.3310/phr07090

Sniehotta FF, Evans EH, Sainsbury K, Adamson A, Batterham A, Becker F, Brown H, Dombrowski SU, Jackson D, Howel D, Ladha K, McColl E, Olivier P, Rothman AJ, Steel A, Vale L, Viiera R, White M, Wright P, Araujo-Soares V. Behavioural intervention for weight loss maintenance versus standard weight advice in adults with obesity: A randomised controlled trial in the UK. PLoS Medicine 2019;16(5), e1002793

Rodgers H, Bosomworth H, Krebs HI, van Wijck F, Howel D, Wilson N, Aird L, Alvarado N, Andole S, Cohen DL, Dawson J, Fernandez-Garcia C, Finch T, Ford GA, Francis R, Hogg S, Hughes N, Price CI, Ternent L, Turner DL, Vale L, Wilkes S, Shaw L. Robot assisted training for the upper limb after stroke (RATULS): a multicentre randomised controlled trial. The Lancet 2019;394 (10192), 51-62

Schaeffer EM, Fisher H, Oluboyede Y, Chadwick T, Abdel-Fattah M, Brennand C, Fader M, Harrison S, Hilton P, Larcombe J, Little P, McClurg, D McColl E, N'Dow J, Ternent L, Thiruchelvam N, Timoney A, Vale L, Walton K, Von Wilamowitz-Moellendorff A, Wilkinson J, Wood R, Pickard R. Continuous Low-Dose Antibiotic Prophylaxis for Adults with Repeated Urinary Tract Infections (AnTIC): A Randomised, Open-Label Trial. Journal of Urology 2019;202(2), Page 191

 

Wright SE, Thomas K, Watson G, Baker C, Bryant A, Chadwick T, Shen J, Wood R, Wilkinson J, Mansfield L, Stafford V, Wade C, Furneval J, Henderson A, Hugill K, Howard P, Roy A, Bonner S, Baudouin S. Intensive versus standard physical rehabilitation therapy in the critically ill (EPICC): A multicentre, parallel-group, randomised controlled trial. Thorax 2018, 73(3), 213-221. https://doi.org/10.1136/thoraxjnl-2016-209858

Howe N, Giles E, Newbury-Birch D, McColl E. Systematic review of participants’ attitudes towards data sharing: a thematic synthesis. Journal of Health Services Research & Policy 2018, 23(2), 123-133. https://doi.org/10.1177/1355819617751555

Homer T, Shen J, Vale L, McColl E, Tincello DG, Hilton P & on behalf of the INVESTIGATE-I studies group. Pilot and Feasibility Studies 2018, 4(1), [67]. https://doi.org/10.1186/s40814-018-0255-y 

Carnell, S.C.; Perry, J.D.; Borthwick, L.; Vollmer, D.; Biboy, J.; Facchini, M.; Bragonzi, A.; Silipo, A.; Vergunst, A.C.; Vollmer, W.; Khan, A.C.M.; De Soyza, A. Targeting the Bacterial Cytoskeleton of the Burkholderia cepacia Complex for Antimicrobial Development: A Cautionary Tale. Int. J. Mol. Sci. 2018;19, 1604 https://doi.org/10.3390/ijms19061604

Pickard R, Chadwick T, Oluboyede Y, Brennand C, von Wiliamowitz-Moellendorff A, McClurg D, Wilkinson J, Ternent L, Fisher H, Walton K, McColl E, Vale L, Wood R, Adbel-Fattah M, Hilton P, Fader M, Harrison S, Larcombe J, Little P, Timoney A, N'Dow J, Armstrong H, Morris N, Walker K, Thiruchelvam N. Continuous low-dose antibiotic prophylaxis to prevent urinary tract infection in adults who perform clean intermittent self-catheterisation: The AnTIC RCT. Health Technology Assessment 2018;22(24), 1-102. https://doi.org/10.3310/hta22240

Kunadian V, Chan D, Ali H, Wilkinson N, Howe N, McColl E, Thornton J, Von Wilamowitz-Moellendorff A, Holstein E-M, Burns G, Fisher A, Stocken D, De Soyza A. Antiplatelet therapy in the primary prevention of cardiovascular disease in patients with chronic obstructive pulmonary disease: protocol of a randomised controlled proof-of-concept trial (APPLE COPD-ICON 2). BMJ Open 2018;8:e020713. doi:10.1136/ bmjopen-2017-020713

Brass D, Fouweather T, Stocken D, Macdonald C, Wilkinson J, Lloyd J, Farr P, Reynolds N and Hampton P. An observer‐blinded randomized controlled pilot trial comparing localized immersion psoralen–ultraviolet A with localized narrowband ultraviolet B for the treatment of palmar hand eczema. Br J Dermatol 2018;179, 63-71. doi:10.1111/bjd.16238

Danilenko M, Stamp E, Stocken DD, Husain A, Zangarini M, Cranston A, Stones R, Sinclair N, Hodgson K, Bowett S, Roblin D, Traversa S, Plummer R, Veal G, Langtry J, Ashworth A, Burn J, Rajan N. . Targeting Tropomyosin Receptor Kinase in Cutaneous CYLD Defective Tumors With Pegcantratinib: The TRAC Randomized Clinical Trial. JAMA Dermatol. 2018;154(8):913–921. doi:10.1001/jamadermatol.2018.1610

Snowden C, Lynch E, Avery L, Gerrand C, Gilvarry E, Goudie N, Haighton C, Hall L, Howe N, Howel D, McColl E, Prentis J, Stamp E & Kaner E. Preoperative Behavioural Intervention versus standard care to Reduce Drinking before elective orthopaedic Surgery (PRE-OP BIRDS): protocol for a multicentre pilot randomised controlled trial. Pilot and Feasibility Studies 2018;4, [140]

Fisher H, Oluboyede Y, Chadwick T, Abdel-Fattah M, Brennard C, Fader M, Harrison S, Hilton P, Larcombe J, Little P, McClurg D, McColl E, N'Dow J, Ternent L, Thiruchelvam N, Timoney A, Vale L, Walton K, von Wilamowitz-Moellendorff A, Wilkinson J, Wood R, Pickard R. Continuous low-dose antibiotic prophylaxis for adults with repeated urinary tract infections (AnTIC): a randomised, open-label trial. The Lancet Infectios Diseases. 2018;18 (9), 957-968

Pinder E, Rostron AJ, Hellyer TP, Ruchaud-Sparagano M-H, Scott J, Macfarlane JG, Wiscombe S, Widdrington JD, Roy AI, Linnett VC, Baudouin SV, Wright SE, Chadwick T, Fouweather T, Juss JK, Chilvers ER, Bowett SA, Parker J, McAuley DF, Morris AC, Simpson AJ. Randomised controlled trial of GM-CSF in critically ill patients with impaired Neutrophil phagocytosis.Thorax 2018;73:918-925.

Forbes R, Ali A, Abouhajar A, Brennard C, Brown H, Carnell S, Chadwick T, Eardley I, Lecouturier J, Mossop H, Pearce I, Pickard R, Thiruchelvam N, Walton K, Wilkinson J, Harding C. Alternatives to prophylactic Antibiotics for the treatment of Recurrent urinary tract infection in women (ALTAR): Study protocol for a multicentre, pragmatic, patient-randomised, non-inferiority trial. Trials: 2018; 19 (1), [616] https://doi.org/10.1186/s13063-018-2998-4

Adams N, Skelton DA, Howel D, Bailey C, Lampitt R, Fouweather T, Gray J, Coe D, Wilkinson J, Gawler S, de Jong L, Waterman H, Deary V, Clarke M & Parry SW. Feasibility of trial procedures for a randomised controlled trial of a community based group exercise intervention for falls prevention for visually impaired older people: the VIOLET study. BMC Geriatrics 2018;18, [307]

Bourke JP, Watson G, Muntoni F, Spinty S, Roper H, Guglieri M, Speed C, McColl E, Chikermane A, Jayawant S, Admani S, Willis T, Wilkinson J, Bryant A, Chadwick T, Wood R, Bushby K. Randomised placebo-controlled trial of combination ACE inhibitor and beta-blocker therapy to prevent cardiomyopathy in children with Duchenne muscular dystrophy? (DMD Heart Protection Study): A protocol study BMJ Open 2018;8 (12):e022572. doi: 10.1136/bmjopen-2018-022572

During 2016/17 core and affiliate NCTU staff have contributed directly to 21 high-quality peer-reviewed clinical trial publications, of which 18 relate to NIHR funded trials.

Harrison D.A., Ferrando-Vivas P., Wright S.E., McColl E., Heyland D.K., Rowan K.M.  Psychometric assessment of the Family Satisfaction in the Intensive Care Unit questionnaire in the United Kingdom.  Journal of Critical Care.  Apr-17; 38: 346-350

McPherson S., Wilkinson N., Tiniakos D., Wilkinson J., Burt A.D., McColl E., Stocken D.D., Steen N., Barnes J., Goudie N., Stewart S., Bury Y., Mann D., Anstee Q.M., Day C.P.  A randomised controlled trial of losartan as an anti-fibrotic agent in non-alcoholic steatohepatitis.  PLoS ONE.  Apr-17; 12:4  e0175717

Deave T., Hawkins A., Kumar A., Hayes M., Cooper N., Watson M., Ablewhite J., Coupland C., Sutton A., Majsak-Newman G., McDaid L., Goodenough T., Beckett K., McColl E., Reading R., Kendrick D.  Evaluating implementation of a fire-prevention injury prevention briefing in children's centres: Cluster randomised controlled trial.  PLoS ONE.  Mar-17; 12:3  e0172584

Nankivell M., Langley R.E., Barton R., Faivre-Finn C., Wilson P., McColl E., Moore B., Brisbane I., Ardron D., Sydes B., Stephens R., Parmar M., Mulvenna P.  How do the QUARTZ trial results inform future research for patients with brain metastases from non-small cell lung cancer?  Translational Cancer Research.  Mar-17; 6: S446-S447

Ali K., Zahra D., Mccoll E., Salih V., Tredwin C.  Impact of early clinical exposure on the learning experience of undergraduate dental students.  European Journal of Dental Education.  2017; DOI: 10.1111/eje.12260

Bell G.M., Anderson A.E., Diboll J., Reece R., Eltherington O., Harry R.A., Fouweather T., MacDonald C., Chadwick T., McColl E., Dunn J., Dickinson A.M., Hilkens C.M.U., Isaacs J.D.  Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis.  Annals of the Rheumatic Diseases.  Jan-17; 76:1 227-234

Armstrong N., Shaw E., McColl E., Tincello D.G., Hilton P.  Trial participation as avoidance strategy: a qualitative study.  Health Expectations.  Dec-16; 19:6 1346-1354

Giles E.L., Coulton S., Deluca P., Drummond C., Howel D., Kaner E., McColl E., McGovern R., Scott S., Stamp E., Sumnall H., Tate L., Todd L., Vale L., Albani V., Boniface S., Ferguson J., Frankham J., Gilvarry E., Hendrie N., Howe N., McGeechan G.J., Stanley G., Newbury-Birch D.  Multicentre individual randomised controlled trial of screening and brief alcohol intervention to prevent risky drinking in young people aged 14-15 in a high school setting (SIPS JR-HIGH): Study protocol.  BMJ Open.  Dec-16; 6-12  e012474

Hilton P., Buckley B.S., McColl E., Howel D., Tincello D.G., Brennand C. Understanding variations in patient screening and recruitment in a multicentre pilot randomised controlled trial: A vignette-based study.  Trials.  Oct-16; 7:1 522

Mulvenna P., Nankivell M., Barton R., Faivre-Finn C., Wilson P., McColl E., Moore B., Brisbane I., Ardron D., Holt T., Morgan S., Lee C., Waite K., Bayman N., Pugh C., Sydes B., Stephens R., Parmar M.K., Langley R.E.  Dexamethasone and supportive care with or without whole brain radiotherapy in treating patients with non-small cell lung cancer with brain metastases unsuitable for resection or stereotactic radiotherapy (QUARTZ): results from a phase 3, non-inferiority, randomised trial.  The Lancet.  Oct-16; 388:1005 2204-2014

Echevarria C., Steer J., Heslop-Marshall K., Stenton S.C., Hickey P.M., Hughes R., Wijesinghe M., Harrison R.N., Steen N., Simpson A.J., Gibson G.J., Bourke S.C.  The PEARL score predicts 90-day readmission or death after hospitalisation for acute exacerbation of COPD.  Thorax.  Aug-17; 72:8 686-693

Pennington L., Lombardo E., Steen N., Miller N.  Acoustic changes in the speech of children with cerebral palsy following an intensive program of dysarthria therapy.  International Journal of Language and Communication Disorders.  2017; DOI: 10.1111/1460-6984.12336 

Hansen C.K., Christensen A., Rodgers H., Havsteen I., Kruuse C., Nybing J., Kaasbøl M.-A., Christensen H.  CT and MRI-based door-needle-times for acute stroke patients a quasi-randomized clinical trial.  Clinical Neurology and Neurosurgery.  Aug-17; 159: 42-49

Rodgers H., Shaw L., Bosomworth H., Aird L., Alvarado N., Andole S., Cohen D.L., Dawson J., Eyre J., Finch T., Ford G.A., Hislop J., Hogg S., Howel D., Hughes N., Krebs H.I., Price C., Rochester L., Stamp E.,Ternent L., Turner D., Vale L., Warburton E., van Wijck F., Wilkes S.  Robot Assisted Training for the Upper Limb after Stroke (RATULS): Study protocol for a randomised controlled trial.  Trials.  Jul-17; 18:1 340

Moore S.A., Da Silva R., Balaam M., Brkic L., Jackson D., Jamieson D., Ploetz T., Rodgers H., Shaw L., van Wijck F., Price C.  Wristband Accelerometers to motiVate arm Exercise after Stroke (WAVES): Study protocol for a pilot randomized controlled trial.  Trials.  Oct-16; 17:1 508

Payne B., Chadwick T.J., Blamire A., Anderson K.N., Parikh J., Qian J., Hynes A.M., Wilkinson J., Price D.A., the Efficacy of Switch to Lopinavir/Ritonavir in Improving Cognitive Function in Efavirenz-treated Patients (SLICE) study team.  Does efavirenz replacement improve neurological function in treated HIV infection?  HIV Medicine.  Oct-17; 18:9 690-695

Fisher A., Andreasson A., Chrysos A., Lally J., Mamasoula C., Exley C., Wilkinson J., Qian J., Watson G., Lewington O., Chadwick T., McColl E., Pearce M., Mann K., McMeekin N., Vale L., Tsui S., Yonan N., Simon A., Marczin N., Mascaro J., Dark J.  An observational study of Donor Ex vivo lung perfusion in UK lung transplantation: DEVELOP-UK.  Health Technology Assessment.  Nov-16; 20:85 276

Akowuah, E., Goodwin, A.T., Owens, W.A., Hancock, H.C., Maier, R., Kasim, A.K., Mellor, A., Khan, K., Murphy, G. & Mason, J.M. (2017). Manubrium-limited ministernotomy versus conventional sternotomy for aortic valve replacement (MAVRIC): study protocol for a randomized controlled trial. Trials 18: 46.

Cox, J., Hancock, H., Maier, R., Spratt, J., Lee, C.M. & Mason, J.M. (2017). Multidetector CT improving surgical outcomes in breast cancer (MISO-BC): A randomised controlled trial. The Breast 32: 217-224.

Rees, C.J., Rajasekhar, P.T., Wilson, A., Close, H., Rutter, M.D., Saunders, B.P., East, J.E., Maier, R.H., Moorghen, M., Muhammad, U., Hancock, H.C., Jayaprakash, A., MacDonald, C., Ramadas, A., Dhar, A. & Mason, J.M. (2017). Narrow band imaging optical diagnosis of small colorectal polyps in routine clinical practice: the Detect Inspect Characterise Resect and Discard 2 (DISCARD 2) study. Gut 66(5): 887-895.

Akowuah, E., Hancock, H., Maier, R., Kasim, A., Zacharias, J., Deshpande, R., Birdi, I., Vale, L., Livesey, S., Stewart, M. & Murphy, G. (2016). Minimally invasive thoracoscopically-guided right minithoracotomy versus conventional sternotomy for mitral valve repair: a multicentre randomised controlled trial (UK Mini Mitral). NIHR Journals Library . https://www.journalslibrary.nihr.ac.uk/programmes/hta/14192110#/