Research

Current Trials:

• A randomised controlled trial of SHORT duration antibiotic therapy for critically ill patients with sepsis (SHORTER)
• Evaluation of efficacy, outcomes and safety of a new infant haemodialysis and ultrafiltration machine in clinical use (I-KID)
• Fractalkine inhibition in acute myocardial infarction (FRACTAL). A phase IIa, randomized, 2-arm parallel-group, placebo-controlled, double-blind, multi-centre trial to evaluate safety, tolerability, anti-inflammatory and cardio- protective effects after intravenous and oral administration of KAND567 in ST-elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention

 Previous Trials:

• A randomised, double-blind, placebo controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression (PAX-BD)
• Optimising primary therapy in primary biliary cholangitis (OPERA)
• Emesis in pregnancy - ondansetron with metoclopramide (EMPOWER)
• Control, fludrocortisone or midodrine for the treatment of orthostatic hypotension: a randomised controlled trial (CONFORM-OH)
• Nasal airway obstruction study (NAIROS)
• Trial of proton pump inhibitors in throat symptoms (TOPPITS)
• Anti-platelet therapy in the primary prevention of cardiovascular disease in patients with chronic obstructive pulmonary disease (APPLE-COPD)

Publications

• Articles

  • Azim L, Hindmarch P, Browne G, Chadwick T, Clare E, Courtney P, Dixon L, Duffelen N, Fouweather T, Geddes JR, Goudie N, Harvey S, Helter T, Holstein EM, Martin G, Mawson P, McCaffery J, Morriss R, Simon J, Smith D, Stokes P, Walker J, Weetman C, Wolstenhulme F, Young AH, Watson S, McAllister-Williams H. Study protocol for a randomised placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression (the PAX-BD study). BMC Psychiatry 2021, 21(21), 334.
  • Rennie KJ, OHara J, Rousseau NS, Stocken DD, Howel D, Ternent L, Drinnan M, Bray A, Rooshenas L, Hamilton DW, Steel A, Fouweather T, Hynes A-M, Holstein E-M, Oluboyede Y, Abouhajar A, Wilson JA, Carrie S. Nasal Airway Obstruction Study (NAIROS): a phase III, open label, mixed methods, multicentre randomised controlled trial of septoplasty versus medical management of a septal deviation with nasal obstruction. BMC Trials 2020, 21(1), 179.
  • Kunadian V, Wilson N, Stocken D, Hani A, McColl E, Burns G, Howe N, Fisher A, De Soyza A. Antiplatelet therapy in the primary prevention of cardiovascular diseasein patients with chronic obstructive pulmonary disease: a randomised controlled proof-of-concept trial. ERJ Open Research 2019, 5(3).
  • Kunadian V, Chan D, Ali H, Wilkinson N, Howe N, McColl E, Thornton J, von Wilamowitz-Moellendorff A, Holstein EM, Burns G, Fisher A, Stocken D, De Soyza A. Antiplatelet therapy in the primary prevention of cardiovascular disease in patients with chronicobstructive pulmonary disease: protocol of a randomised controlled proof-of-concept trial (APPLE COPD-ICON 2). BMJ Open 2018, 8, e020713.
  • Holstein EM, Ngo G, Lawless C, Banks P, Greetham M, Wilkinson D, Lydall D. Systematic Analysis of the DNA Damage Response Network in Telomere Defective Budding Yeast. G3: Genes, Genomes, Genetics 2017, 7(7), 2375-2389.
  • Holstein E-M, Clark KRM, Lydall DA. Interplay between Nonsense-Mediated mRNA Decay and DNA Damage Response Pathways Reveals that Stn1 and Ten1 Are the Key CST Telomere-Cap Components. Cell Reports 2014, 7(4), 1259-1269.
  • Addinall SG, Holstein EM, Lawless C, Yu M, Chapman K, Banks AP, Ngo HP, Maringele L, Taschuk M, Young A, Ciesiolka A, Lister AL, Wipat A, Wilkinson DJ, Lydall D. Quantitative Fitness Analysis Shows That NMD Proteins and Many Other Protein Complexes Suppress or Enhance Distinct Telomere Cap Defects. PLoS Genetics 2011, 7(4), e1001362.
  • Weile J, Pocock M, Cockell SJ, Lord P, Dewar JM, Holstein EM, Wilkinson D, Lydall D, Hallinan J, Wipat A. Customizable views on semantically integrated networks for systems biology. Bioinformatics 2011, 27(9), 1299-1306.

• Book Chapters

  • Holstein E-M, Lawless C, Banks P, Lydall D. Genome-wide Quantitative Fitness Analysis (QFA) of yeast cultures. In: Marco Muzi-Falconi, Grant W Brown, ed. Genome Instability: Methods and Protocols. New York: Humana Press Inc, 2018, pp.575-597.
  • Holstein EM, Lydall David. Quantitative amplification of single-stranded DNA (QAOS). 2012.