Newcastle Clinical Trials Unit

Staff Profile

Dr Eva-Maria Holstein

Clinical Trial Administrator


Current Trials:

  • A randomised controlled trial of SHORT duration antibiotic therapy for critically ill patients with sepsis (SHORTER)
  • Evaluation of efficacy, outcomes and safety of a new infant haemodialysis and ultrafiltration machine in clinical use (I-KID)
  • Fractalkine inhibition in acute myocardial infarction (FRACTAL). A phase IIa, randomized, 2-arm parallel-group, placebo-controlled, double-blind, multi-centre trial to evaluate safety, tolerability, anti-inflammatory and cardio- protective effects after intravenous and oral administration of KAND567 in ST-elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention

 Previous Trials:

  • A randomised, double-blind, placebo controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression (PAX-BD)
  • Optimising primary therapy in primary biliary cholangitis (OPERA)
  • Emesis in pregnancy - ondansetron with metoclopramide (EMPOWER)
  • Control, fludrocortisone or midodrine for the treatment of orthostatic hypotension: a randomised controlled trial (CONFORM-OH)
  • Nasal airway obstruction study (NAIROS)
  • Trial of proton pump inhibitors in throat symptoms (TOPPITS)
  • Anti-platelet therapy in the primary prevention of cardiovascular disease in patients with chronic obstructive pulmonary disease (APPLE-COPD)