Newcastle Clinical Trials Unit


SarcoSIGHT: A Randomised-Control Trial of Fluorescence Guided Sarcoma Surgery Versus the Standard of Care

  • Study stage: Set-up
  • Sponsor:  The Newcastle Upon Tyne Hospitals NHS Foundation Trust
  • Funder:  National Institute for Health and Care Research (NIHR) Efficacy and Mechanism Evaluation (EME) Programme
  • Therapeutic area: Cancer and Neoplasm
  • Type of study:  Surgical

Aim: To determine whether FGS using ICG reduces the UPM rate compared to the current standard of care (SoC).

Primary Outcome: The UPM rate, defined as the percentage of patients with an unexpected positive margin, will be compared between the two treatment arms.

  • Population: Adult
  • Design: RCT (open label)
  • Setting: Secondary Care
  • Planned Sample Size: 500