Newcastle Clinical Trials Unit



A pragmatic, multicentre, placebo controlled, double blind, parallel, randomised controlled trial of liquid alginate (Gaviscon Advance) for the treatment of persistent throat symptoms

 Study Stage: Set-up

  • Sponsor:  The Newcastle upon Tyne Hospitals NHS Foundation Trust
  • Funder:  IIT (Reckitt)
  • Therapeutic area: Ear, Nose and Throat
  • Type of study: CTIMP

Aim: To compare the symptomatic response in patients with persistent throat symptoms to a liquid alginate (Gaviscon Advance) compared to matched placebo.

Primary Outcome: Total Reflux Symptom Index (RSI) score at 8 weeks

  • Clinical Phase: III
  • Population: Adult
  • Design: Randomised, double-blind, placebo-controlled, parallel designed trial
  • Setting: Secondary Care
  • Planned Sample Size: 250