Newcastle Clinical Trials Unit

Met Prevent


Metformin to prevent progression of sarcopenia and frailty in older people – a double blind, randomised controlled proof of concept trial

Study stage: Closedown/Analysis
Sponsor: The Newcastle upon Tyne Hospitals NHS Foundation Trust
Funder: NIHR Newcastle Biomedical Research Centre
Therapeutic area: Musculoskeletal
Type of study: CTIMP

Aim: Provide proof-of-concept evidence as to whether metformin can improve physical performance in older people with sarcopenia and prefrailty

Primary Outcome:  The between-group difference in 4m walk speed at 4 months, adjusted for baseline values.

Population: Ageing
Clinical Phase: IIII
Design: Randomised Control Trial (RCT)
Setting: Secondary Care
Planned Sample Size: 80