Northern Institute for Cancer Research

DNA and cell damage repair and response

DNA and cell damage repair and response


Dysregulation of DNA and cell damage response pathways is a common feature of many cancer types. It can drive DNA replication and cancer cell proliferation, even with DNA damage in the genome that would be toxic to non-cancer cells.

Research Leaders

James Allan
Nicola Curtin
John Lunec
Helen Reeves
Ruchi Shukla


Reliance on DNA damage response pathways for cancer cell survival makes them potential targets for therapy.

We're exploiting this strategy to develop inhibitors against key components of damage response pathways. These include:

  • DNA protein kinase
  • ATM
  • ATR

We are also developing ways of activating downstream DNA damage and stress response signalling pathways to kill cancer cells without damaging DNA. This includes the p53 signalling network targets:

  • MDM2-p53 binding
  • PPM1D/WIP1 phosphatase


Prof. Nicola Curtin’s staff:

Yvette Drew
Rachel O'Donnell
Asima Mukhopadhyay
Ali Kucukmetin

Lucy Gentles

PhD student:
Alice Bradbury

MD students:
Ioannis Kotsopoulos
Stuart Rundle

Dr. Ruchi Shukla’s staff:

PhD student:
Bassier Zadran