Northern Institute for Cancer Research

Lymphoma

Lymphoma Research

About

Our research focuses on interrogating the genomic landscape of paediatric lymphoma. We identify biomarkers and develop targeted therapies.

Research Leaders

Dr Vikki Rand
Dr Simon Bomken
Dr Chris Bacon

About

Lymphoma is a heterogeneous group of malignancies. Depending on the age of diagnosis, the incidence of different histological subtypes and patient survival varies.

The primary aim of our group is to elucidate the underlying abnormalities in Burkitt lymphoma (endemic and sporadic) and diffuse large B-cell lymphoma to identify biomarkers.

This work permits the risk stratification of patients. We also evaluate genomic alterations as therapeutic targets.

Our ultimate aim is to identify those patients at greatest risk and to develop strategies to successfully treat them. This will improve survival for children diagnosed with B- and T-cell lymphoma in developed and developing countries.

One of our researchers screening patient samples using fluorescence in situ hybridisation (FISH).
We screen patient samples using fluorescence in situ hybridisation (FISH) to detect the IGH-MYC translocation.

Our research

Our research

We have established cohorts of clinically annotated samples. These are from patients treated in the UK Children’s Cancer and Leukaemia Group network and at the Queen Elizabeth Central Hospital in Blantyre, Malawi.

We use a combination of cutting-edge techniques to define the genomic landscape. We investigate the biology of lineage specifying, and activation-induced transcription factors in aggressive B-cell and T-cell malignancies. This is aimed at identifying new therapeutic targets.

To enable pre-clinical testing of new therapies we have developed in vitro and in vivo patient-derived models.

A computer screen showing genomic analysis.
We do genomic analysis of paediatric Burkitt lymphoma to reveal recurrent copy number abnormalities in tumour samples.

Collaboration

We work with Paediatric Immunology colleagues at the Great North Children’s Hospital. We've a special interest in the molecular, pathological and clinical aspects of lymphoma in children with immune deficiency. This is either following bone marrow/solid organ transplantation or as an inherited immune deficiency syndrome. 

We collaborate with Newcastle MRC Pathology Node and colleagues in Cellular Pathology. Together, we're translating new understanding of the molecular and cellular basis of lymphoma into the clinical diagnostic setting. 

We collaborate to provide pathology support for clinical trials and pre-clinical studies. We also conduct biological studies. This work is both local and national. 

One of our researchers doing functional analysis of genomic abnormalities.
We do functional analysis of genomic abnormalities using in vitro and in vivo models.

Publications

Carey C, Gusenleitner D,  Chapuy B, Kovach AE, Kluk MJ, Sun HH, Crossland RE, Bacon CM, Rand V,  Cin PD, Le PL, Neuberg D, Sohani AR, Shipp MA, Monti S, Rodig SJ (2014) Molecular Classification of MYC-Driven B-cell Lymphomas by Targeted Gene Expression Profiling of Fixed Biopsy Specimens The Journal of Molecular Diagnostics 17(1):19-30

Bacon CM, Wilkinson SJ, Spickett GP, Barge D, Lucraft HH, Jackson G, Rand V, Gennery AR (2013) Epstein-Barr virus-independent diffuse large B-cell lymphoma in DNA ligase 4 deficiency. Allergy Clin Immunol. 131(4):1237-9 IF 12.485

Selected conference abstracts published in British Journal of Haematology:

Zhou P, Newman AM, Van Noorden S, Banda K, Chagaluka G, Lampert I, Erhorn A, Bacon C, Bailey S Molyneux E, Rand V (2015) Investigation of prognostic markers in endemic Burkitt lymphoma. British Journal of Haematology. 2015;171:2. Oral Presentation at the 5th International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin Lymphoma, Varese, Italy

Bell N, Blair H, Noble R, Price L, Wood KM, Vormoor J, Bacon C, Rand V, Heidenreich O, Wedge S, Bomken S (2015) Patient-derived xenograft and in vivo bioluminescent modelling of B cell NHL Poster presentation at the 5th International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin Lymphoma, Varese, Italy.

Zhou P, Crossland RC, Erhorn A, Rand V (2015) High-resolution copy number analysis using low input, degraded DNA from ?ne-needle aspirates and macrodissected archival Burkitt lymphoma material. British Journal of Haematology. 2015;171:62. Poster presentation at the 5th International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin Lymphoma, Varese, Italy.

Crossland RC, Green K, Bacon C, Rand V (2015) Direct digital pro?ling of multiplexed mRNA expression from degraded formalin ?xed paraf?n embedded aggressive paediatric B-celll ymphoma tumour tissue 171:120 Poster presentation at the 5th International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin Lymphoma, Varese, Italy

Staff

Dr Peixun Zhou – Research Associate
Dr Natalie Bell – Research Associate
Dr Rachel Crossland – Research Associate
Dr Chris Carey – Clinical Fellow
Alex Newman – PhD Student
Sarah Wilkinson – Research Assistant
Dr Amy Erhorn – Research Technician
Amy Barnard – Research Technician
Adam Bloomfield – Intercalating MRes Student