Northern Institute for Cancer Research

Staff Profile

Dr Emma Clark

Research Associate

Background

Personal Summary

Building on a strong prostate cancer research background I have moved my research interest focus away from basic, early discovery research to build urological clinical research expertise. Where basic science has shown the potential to make a real difference I aim to work this to the next stage in order to move this to clinical practice as quickly as possible. I work with a portfolio of clinical trial studies where I have taken management of the translational lead and facilitate gaining funding for these types of studies.

Qualifications

PGCert 2015 Clinical Research, Newcastle University, UK

PhD 2006 Molecular Cancer Biology, Newcastle University, UK

BSc 1999 (Hons) Biochemistry, University of Sussex, UK

Area of expertise:


Translational Clinical Trial Research (assay development, clinical and biological validation and clinical utility)


Biomarker Discovery (prognostic/diagnostic in terms of treatment/disease outcomes, personalised medicine)


Urology based research specialising in molecular biology of hormone escape in Prostate Cancer (Androgen Receptor transcriptional control)

Previous Positions

2006-2014 Research Associate - Urological Cancer, Northern Institute for Cancer Research, Newcastle University, UK

2002- 2005 BBSRC (GSK Case) PhD Student - Institute for Cell & Molecular Biosciences, Newcastle Univeristy, UK

2001-2002 Research Assistant - Dept. of Fetal Medicine, Birmingham Womens Hospital, UK

1999-2001 Graduate Pharmaceutical Scientific Researcher - Roche, Welwyn Garden City, UK

1997-1998 Industrial Studentship Placement - Home Office Forensic Science Service, Birmingham, UK

Membership/Committees

  • UK NCRI Clinical Trials Pathology Advisory Group (CT-PAG)

  • Faculty of Medical Science Newcastle University Ethics committee

  • NICR Newcastle University Equality and Diversity committee

  • BACR and EACR



Research

Research Interests

Translational Clinical Trial work - assay development, clinical and biological validation and clinical utility

Biomarker Discovery - prognostic/diagnostic in terms of treatment/disease outcomes (personalised medicine)

Urology based research specialising in molecular biology of hormone escape in Prostate Cancer (Androgen Receptor transcriptional control)

Specific projects:

Designed, set up and lead applicant for NIHR RfPB funded VARIANT trial (multi-site, biomarker guided, randomised feasibility trial) in advanced prostate cancer. Set up biomarker assay NICR lab to GCP/GCLP requirements.

Designed, set up and lead of the translational arm of HTA NIHR PHOTO trial (a multi-site, pragmatic, randomised controlled phase III trial: ISRCTN 84013636).

Trial managed single-site, pragmatic, observational commercial Sanofi funded trial (GenCab, NIHR portfolio study CSP 102842), which correlated prostate tumour molecular biology with clinical response to Cabazitaxel chemotherapy.

Historical research interest in p68 DEAD Box RNA Helicase (DdX5) cellular function and phosphatase regulation of the Androgen Receptor.

Funding 

NIHR RfPB feasibility study (The Prostate Cancer Androgen Receptor Splice Variant 7 Biomarker Trial (The VARIANT trial) - A multicentre feasibility study of biomarker-guided personalised treatment in advanced prostate cancer - £276,230.00) awarded to Dr. E. L. Clark and Mr. Rakesh Heer (June 2018 - Sept 2020).

PCUK PhD post (Characterising novel phosphatase enzymes important in regulating androgen receptor function in the progression of castrate resistant prostate cancer - £100.3K) awarded to Dr. E. L. Clark and Prof. C. N. Robson (Sept 2013-Sept 2016) 

JGWP technical support post (Assessing the role of RNA helicase p68 (Ddx5) in the deregulation of microRNAs and progression of Prostate Cancer - £52K) awarded to Dr. E. L. Clark and Prof. C. N. Robson (May 2012-May 2013)

Prostate Action project grant (Assessing RNA helicase p68 (Ddx5) as a biomarker in the deregulation of microRNAs in Prostate Cancer - £99,987) awarded to Dr. E. L. Clark and Prof. C. N. Robson (Jan 2012-Oct 2013)

PCRF project grant (Pharmacological perturbation of p68 - an important androgen receptor transcriptional co-regulator in prostate cancer - £99,941) awarded to Dr. E. L. Clark and Prof. C. N. Robson (Jan 2008- Dec 2011)

Industrial Relevance

1999 - 2001 Graduate Pharmaceutical Scientific Researcher, Roche, Welwyn Garden City, UK

 

Teaching

Postgraduate Teaching

Past and current students:

Nana-Jane Chipampe PhD (2017 -

Alex Lloyd MRes (2017 - 2018)

Emma Smith MRes (2016 - 2017)

Andrew Evans MRes (2015 - 2016)

James Grey PhD (2014 - 2016)

Victoria Shuttleworth UG (2011 - 2012)

Jake Clayton MRes (2010 - 2011)

Christiana Hadjimichael MRes (2007-2008)



Publications