Northern Institute for Cancer Research

Staff Profile

Dr Paul Sinclair

Senior Research Associate


Roles and Responsibilities

My responsibilities are to develop novel lines of research aimed at identifying genes involved in the development or relapse of leukaemia.


1982; BSc. in Applied Biology, Class 2[II], University of Bradford.
1984; Postgraduate Diploma in Genetic Toxicology, University of Swansea.
2002; PhD. in Haematology, University College London.

Areas of expertise

Genomic and functional characterisation of childhood leukaemia

Previous Positions

1984 -1986: Study Investigator with Microtest Research Ltd, University of York, UK
1986 -1989: Basic Grade Cytogeneticist, Regional Cytogenetics Unit, St Mary's Hospital, Manchester.
1989 -1991: Research Training Fellow, Department of Medical Genetics, St Mary's Hospital, Manchester
1993: English Teacher, English American College, Malaga, Spain.
1994-1998: Clinical Scientist, Department of Haematology, Addenbrooke's Hospital, Cambridge.
1999-2004: Research Assistant, Academic Department of Haematology, Royal Free and University Hospital School of Medicine, London
2004-2008: Research Associate, Department of Cell and developmental Biology, University of Illinois, Urbana, USA.


Intermediate Spanish


Research Interests

Main areas of expertise are cytogenetics and molecular genetics, cell biology and analysis of nuclear structure. Main research interests are the genetics of human leukaemia and changes in higher order chromatin structure associated with differentiation of embryonic stem cells.

Current Work

1. Analysis of a breakpoint cluster region associated with intrachromal amplification of chrmosome 21 in paediatric-pre-B cell leukaemia.
2. Development of a high-throughput in-vivo assay for the identification of candidate oncogenes and tumour suppressor genes in Leukaemia.

Future Research

Analysis of candidte oncogenes and tumour suppressor genes from chromosomal regions that are recurrently lost or gained or mutated in haematological malignancies using in-vivo models of leukaemia.

Research Roles

My current research roles are 1) the analysis and interpretation of sequences of breakpoints of chromosomal abnormalities in Leukaemia.
2) The introduction of novel in-vivo assays for the identification of novel oncogenes and tumour suppressor genes.

Postgraduate Supervision

None currenty. I will have responsibility for the supervision of a PhD student to commence within the next 18 months.


I played a major role in the preparation of two successful grant applications. 1) A Tyneside Research Asociation grant. To fund myself as a postdoctoral RA for 18 months.
2) An ERC advanced grant. To fund a 5 year research program aimed at introducing in-vivo models for the identification of novel genes contributin to leukaemia.