Northern Institute for Cancer Research

Staff Profile

Dr Suzannah Harnor

Senior Research Associate

Background

I am currently a Research Associate based in the Northern Institute for Cancer Research Medicinal Chemistry Labs, working as part of the multi-disciplinary, anti-cancer drug discovery programme. 

Working in close conjunction with the Newcastle and Astex bioscience and structural biology groups, I play a role in the design and synthesis of small-molecule antitumour agents and am active in the co-supervision of medicinal chemistry team members. 

Qualifications:
PhD in Organic Chemistry (University of Glasgow)
Studies Towards the Synthesis of LL-Z1640-2 and Spirocyclic Systems.

  • Established and optimised a synthetic route to the 14-membered macrocycle, LL-Z1640-2.  The challenge of the total synthesis was addressed by the development of a flexible, economic and efficient synthesis.
  • A concise method towards highly functionalised spirocyclic piperidine units was achieved using the regioselective aza-Achmatowicz oxidative rearrangement. 

MSc by Research in Carbohydrate Chemistry (University of Dundee)  
Synthesis of Di- and Tri-Saccharide Fragments of a GPI Anchor from Leishmania.    

  • Synthetic targets were fragments of the GPI anchor of Leishmania lipophosphoglycan, containing β-D-Galf at the terminus.  Chemical syntheses of neutral disaccharides and trisaccharides, as well as the preparation of phosphorylated trisaccharides, were undertaken.

BSc (Hons) in Chemistry with Pharmacology (University of Dundee)                            
Synthesis of (1R, 2R)-2-O-(2,3,4,6-Tetra-O-benzoyl-α-D-mannopyranosyl-cyclohexanol.

Area of expertise

  • Medicinal Chemistry

SCOPUS: Click here.

Publications