School of Pharmacy

News

Prof. Moein Moghimi has published a new paper in the Journal of Pharmacology and Experimental Therapeutics

“The interplay between blood proteins, complement, and macrophages on nanomedicine performance and responses”.

 Abstract

In the blood, nanoparticles, depending on their physicochemical characteristics, attract a wide range of plasma biomolecules.  The majority of blood biomolecules bind non-specifically to nanoparticles.  On the other hand, biomolecules such as pattern-recognition complement-sensing proteins may recognize some structural determinants of the pristine surface causing complement activation.  Adsorption of non-specific blood proteins could also recruit natural antibodies and initiate complement activation, and this seems a global process with many pre-clinical and clinical nanomedicines.  We discuss these issues, since complement activation has ramifications in nanomedicine stability and pharmacokinetics, as well as in inflammation and disease progression.  Some studies have also predicted a role for complement system in infusion-related reactions, whereas others show a direct role for macrophages and other immune cells independent of complement activation.  We comment on these discrepancies, and suggest directions for exploring the underlying mechanisms.

The full paper can be found here

Prof. Moein Moghimi

published on: 16 April 2019