School of Pharmacy

Staff Profile

Dr Alessio Iannetti

Teaching Fellow

Background

Teaching Fellow at the School of Pharmacy since September 2017.

Other roles

School of Pharmacy Student-Staff Committee staff facilitator

Part of base group 4 


Qualification

Fellow of the Higher Education Academy, following completion of CASAP, module MDSL

Newcastle Teaching Award


Funding

BBSRC-DTP-PhD studentship

Regulation of NF-kB signalling by ribotoxic stress with N Perkins, N Watkins and S Rocha

ULSTEC Innovation awards

Student-staff partnerships in curriculum review and development with H Nazar

FMS Education Research Development and Practice Grants

Tackling the common issues of the faculty’s student academic representation system in a half-day event with L Wakeling

School of Pharmacy Staff Development Funds 

Day-visit for students in a Pharmaceutical Company

Previous positions at Newcastle University

2015-2017: Senior Research Associate at the Northern Institute for Cancer Research. I was part of the Bioscience/Target Validation Team of the Drug Discovery Group where I managed and led some of the activities of several projects. In particular the identification, study and validation of targets for cancer therapy with the development of new molecular and genetic approaches. These projects were part of a strategic alliance with Astex Pharmaceuticals to identify and develop new cancer drugs and associated biomarkers.  

2010-2015: Research Associate at the Institute of Cell and Molecular Biosciences. I studied the molecular mechanisms of the cross-talks regulating the activity of  the transcription factor NF-kB and the oncosuppressor p53 in cellular senescence and stress responses. I also identified new proteins regulating the alternative NF-kB pathway by proteomic screening. In 2013 I was successful in securing funding from WorldWide Cancer Research, which funded my remaning period in the lab


Education  

2005-2009:
PhD student at University of Naples Federico II, Institute of Cellular-Molecular Pathology. PhD project: "The Neutrophil Gelatinase Associated Lipocalin" (NGAL), a NF-kB regulated gene, is a survival factor for thyroid neoplastic cells"

2000-2005: Msci in Medical Biotechnologies, University of Naples Federico II  


Research

Current research Interests

Identification and study of novel NF-kB interacting proteins and regulated genes in cancer and other diseases

Regulation of NF-kB signalling by ribotoxic stress

Other research interests

Inflammation and cancer, focussing on the role of the NF-kB transcription factor and the role of cross-talks between NF-kB and p53 and additional transcription factors 

Identification and validation of novel targets for cancer therapy

Development of new technologies in molecular biology (CRISPR technology for cell line engineering and pull-down assay for the study of DNA-proteins interaction)


Education Research interests

The use of learning technologies to enhance student experience and promote student engagement. In particular the use of games in Pharmacy education

Student-Staff partnership in curriculum review

Improving the Faculty’s Student Academic Representation system

Member of FMS Education Research Development and Practice 

Teaching

Master of Pharmacy with Honours. B230. Stage1-2-3-4

Lectures

Stage 1-2-3-4: Cell Biology, Physiology, Immunology, Pathophysiology, Oncology, Pharmacology

Practicals

Stage 1-2-3: Physiology & Pharmacology classes


Previous teaching

Biochemistry (BGM1002), Cell Biology and Disease (BMS2002), Physiology (PSC1002), Microbiology & Immunology (CMB1006), School of Biomedical Sciences.

Immunology and Biochemistry, School of Medical Biotechnologies. University of Naples Federico II.


Student supervision

Supervision and training in research of undergraduates, postgraduates and summer students


Publications

  • Iannetti A, Ledoux AC, Tudhope SJ, Sellier H, Zhao B, Mowla S, Moore A, Hummerich H, Gewurz BE, Cockell SJ, Jat PS, Willmore E, Perkins ND. Regulation of p53 and Rb Links the Alternative NF-kappa B Pathway to EZH2 Expression and Cell Senescence. PLoS Genetics 2014, 10(9).
  • Ledoux AC, Sellier H, Gillies K, Iannetti A, James J, Perkins ND. NF kappa B regulates expression of Polo-like kinase 4. Cell Cycle 2013, 12(18), 3052-3062.
  • Pacifico F, Crescenzi E, Mellone S, Iannetti A, Porrino N, Liguoro D, Moscato F, Grieco M, Formisano S, Leonardi A. Nuclear factor-{kappa}B contributes to anaplastic thyroid carcinomas through up-regulation of miR-146a. The Journal of Clinical Endocrinology & Metabolism 2010, 95(3), 1421-30.
  • Iannetti A, Pacifico F, Acquaviva R, Lavorgna A, Crescenzi E, Vascotto C, Tell G, Salzano AM, Scaloni AM, Vuttariello E, Chiappetta G, Formisano S, Leonardi A. The neutrophil gelatinase-associated lipocalin (NGAL), a NF-κB-regulated gene, is a survival factor for thyroid neoplastic cells. Proceedings of the National Academy of Sciences of the United States of America PNAS, Proceedings of the National Academy of Sciences 2008, 105(37), 14058-14063.
  • DelVecchio P, Carullo P, Barone G, Pagano B, Graziano G, Iannetti A, Acquaviva R, Leonardi A, Formisano S. Conformational stability and DNA binding energetics of the rat thyroid transcription factor 1 homeodomain. Proteins 2008, 70(3), 748-760.
  • Mauro C, Pacifico F, Lavorgna A, Mellone S, Iannetti A, Acquaviva R, Formisano S, Vito P, Leonardi A. ABIN-1 Binds to NEMO/IKKγ and Co-operates with A20 in Inhibiting NF-κB. The Journal of Biological Chemistry 2006, 281(27), 18482-8.