Newcastle Preclinical In Vivo Imaging Facility



The following publications resulted from research projects which acknowledge the use of the In Vivo Imaging System facility.


Dr. Dumitru Sirbu, Dr. Saimir Luli, Dr. Jack Leslie, Prof. Fiona Oakley Prof. Andrew C. Benniston. Enhanced in vivo Optical Imaging of the Inflammatory Response to Acute Liver Injury in C57BL/6 Mice Using a Highly Bright Near‐Infrared BODIPY Dye. ChemMedChem 2019,14,995 –999


Dr Lynsey McKenzie, Hasan Issa, Sandeep Potluri, Dr Helen Blair, Asmida Isa, Dr Ricky Tirtakusuma, Dan Coleman, Dr Sirintra Nakjang, Dr Victoria Forster, Dr Mojgan Reza, Dr Edward Law, Philip Berry, Dr Simon Bomken, Dr Deepali Pal, Professor James Allan, Professor Gareth Veal, Professor Olaf Heidenreich. The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation. Cancer Cell 34, 626–642, October 8, 2018

Sarah E. Fordham, Helen J. Blair, Claire J. Elstob, Ruth Plummer, Yvette Drew, Nicola J. Curtin, Olaf Heidenreich, Deepali Pal, David Jamieson, Catherine Park, John Pollard,2 Scott Fields, Paul Milne, Graham H. Jackson, Helen J. Marr, Tobias Menne, Gail L. Jones, and James M. Allan. Inhibition of ATR acutely sensitizes acute myeloid leukemia cells to nucleoside analogs that target ribonucleotide reductase. Blood Advances. 2018 May 22;2(10):1157-1169.

Paul. B. Sinclair, Helen H. Blair, Sarra L. Ryan, Lars Buechler, Joanna Cheng, Jake Clayton, Rebecca Hanna, Shaun Hollern, Zoe Hawking, Matthew Bashton, Claire J. Schwab, Lisa Jones, Lisa J. Russell, Helen Marr, Peter Carey, Christina Halsey, Olaf Heidenreich, Anthony V. Moorman, Christine J. Harrison. Dynamic Clonal Progression In Xenografts Of Acute Lymphoblastic Leukemia With Intrachromosomal Amplification Of Chromosome 21. Haematologica April 2018 103: 634-644;


Elder, Bomken S, Wilson I, Blair HJ, Cockell S, Ponthan F, Dormon K1, Pal D, Heidenreich O, Vormoor J.Abundant and equipotent founder cells establish and maintain acute lymphoblastic leukaemia. Leukemia. 2017 Dec;31(12):2577-2586. doi: 10.1038/leu.2017.140. Epub 2017 May 10.

McCormick A, Earp E, Elliot K, Cuthbert G, O'Donnell R, Wilson BT, Sutton R, Leeson C, Thomas HD, Blair H, Fordham S, Lunec J, Allan J, Edmondson RJ. Functional characterisation of a novel ovarian cancer cell line, NUOC-1. Oncotarget. 2017, 8(16), 26832-26844.

Noble RA, Bell N, Blair H, Sikka A, Thomas H, Phillips N, Nakjang S, Miwa S, Crossland R, Rand V, Televantou D, Long A, Keun HC, Bacon CM, Bomken S, Critchlow SE, Wedge SR. Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and burkitt lymphoma. Haematologica. 2017, 102(7), 1247-1257.

Meyer SK, Probert PM, Lakey AF,  Axon AR, Williams FM, Jowsey PA, Blain PG, Kass GE, Wright MC.  Hepatic effects of tartrazine (E 102) are independent of oestrogen receptor interactions in the mouse.  Toxicol Letts, In press (2017).


Luli S, Di Paolo D, Perri P, Brignole C, Hill SJ, Brown H, et al. A new fluorescence-based optical imaging method to non-invasively monitor hepatic myofibroblasts in vivo. J Hepatol. 2016. Epub 2016/04/14. doi: 10.1016/j.jhep.2016.03.021. IF 11.336

Pal D, Blair HJ, Elder A, Dormon K, Rennie KJ, Coleman DJ, et al. Long-term in vitro maintenance of clonal abundance and leukaemia-initiating potential in acute lymphoblastic leukaemia. Leukemia. 2016. PubMed PMID: 27109511. IF 10.431

Fox C, Cocchiaro P, Oakley F, Howarth R, Callaghan K, Leslie J, et al. Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease. Sci Rep. 2016;6:20101. PubMed PMID: 26831567; IF 5.578

Roughan JV, Bertrand HG, Isles HM. Meloxicam prevents COX-2-mediated post-surgical inflammation but not pain following laparotomy in mice. Eur J Pain. 2016;20(2):231-40. PubMed PMID: 25908253. IF 3.218

Moles A, Butterworth JA, Sanchez A, Hunter JE, Leslie J, Sellier H, et al. A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-kappaB-dependent liver regeneration and cancer. Oncogene 2016. PubMed PMID: 26853469. IF 8.459

Miller, A., Burson, H., Söling, A. and Roughan, J. V. Welfare assessment following heterotopic or orthotopic inoculation of bladder cancer in C57BL/6. PLOS ONE 2016. Submitted. IF 3.234


Wilson CL, Jurk D, Fullard N, Banks P, Page A, Luli S, et al. NFkappaB1 is a suppressor of neutrophil-driven hepatocellular carcinoma. Nat Commun. 2015;6:6818. PubMed PMID: 25879839. IF 11.47

Hunter JE, Butterworth JA, Zhao B, Sellier H, Campbell KJ, Thomas HD, et al. The NF-kappaB subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma. Oncogene. 2015. PubMed PMID: 26522720. IF 8.459


Scherr M, Elder A, Battmer K, Barzan D, Bomken S, Ricke-Hoch M, et al. Differential expression of miR-17~92 identifies BCL2 as a therapeutic target in BCR-ABL-positive B-lineage acute lymphoblastic leukemia. Leukemia. 2014;28(3):554-65. PubMed PMID: 24280866. IF 10.431

Vormoor B, Knizia HK, Batey MA, Almeida GS, Wilson I, Dildey P, et al. Development of a preclinical orthotopic xenograft model of ewing sarcoma and other human malignant bone disease using advanced in vivo imaging.PLoS One. 2014;9(1):e85128. PubMed PMID: 24409320. IF 3.234


Moles A, Sanchez AM, Banks PS, Murphy LB, Luli S, Borthwick L, et al. Inhibition of RelA-Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response. Hepatology. 2013;57(2):817-28. PubMed PMID: 22996371. IF 11.055

Bomken S, Buechler L, Rehe K, Ponthan F, Elder A, Blair H, et al. Lentiviral marking of patient-derived acute lymphoblastic leukaemic cells allows in vivo tracking of disease progression. Leukemia. 2013;27(3):718-21. PubMed PMID: 22858908. IF 10.431

Robinson SM, Mann DA, Manas DM, Oakley F, Mann J, White SA. The potential contribution of tumour-related factors to the development of FOLFOX-induced sinusoidal obstruction syndrome. Br J Cancer. 2013;109(9):2396-403. PubMed PMID: 24113143. IF 4.836