Postgraduate

Modules

Modules

CHS8001 : Drug Discovery and Pre-clinical Development (E-learning) (Inactive)

Semesters
Semester 1 Credit Value: 20
ECTS Credits: 10.0

Aims

To develop a cohort of learners who have a detailed understanding of the first stage of Translational Medicine, namely the drug discovery and pre-clinical development process. They should be able to demonstrate application of their learning including in their own research or translational careers. The learners should have a clear appreciation of the role that regulatory authorities play in ensuring the efficacy and safety of new compounds.

Outline Of Syllabus

The module covers the following topics:

Drug absorption, distribution, metabolism and elimination (Pharmacokinetics)
Mechanisms of drug action (Pharmacodynamics) and Inter-individual variability in pharmacokinetics and drug effects (Pharmacogenetics)
Overview of the Drug Discovery & Pre-clinical development process
Targets and target validation
Screening and hits
Molecular biology therapeutics
Optimising molecules
Pre-clinical in vitro studies
Toxicology

Teaching Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

Teaching Activities
Category Activity Number Length Student Hours Comment
Guided Independent StudyAssessment preparation and completion315:0045:00N/A
Guided Independent StudyDirected research and reading99:0081:00Online content
Guided Independent StudySkills practice11:001:00Use of software
Guided Independent StudyStudent-led group activity52:0010:00online exercises
Guided Independent StudyIndependent study94:0036:00Supplemental reading
Guided Independent StudyOnline Discussion93:0027:00N/A
Total200:00
Teaching Rationale And Relationship

The online content is a way of delivering highly detailed content in an interactive, interesting and diverse way. The combination of text, problems, MCQ questions, video, animations and other interactive tasks should allow learning across a wide range of learning styles. The syllabus is highly specialised and most learners will have only limited prior specific knowledge – meaning that this content rich delivery is necessary. This teaching method links primarily to the knowledge based outcomes for each topic.

The problem based, often collaborative online exercises (with submissions to discussion boards, blogs, journals, wikis) are designed to consolidate learning from the directed eLearning and promote application of that learning in an adult learning based way.

The coursework project is chosen to promote further consideration of how the whole drug discovery process is linked together and to ensure the learners are able to apply their learning (“Do”) rather than simply “know”. This is what the pharmaceutical and academic stakeholders require from the learners. This teaching method is linked particularly directly to the first and second skills outcomes but also to all of the knowledge outcomes.

Assessment Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

The format of resits will be determined by the Board of Examiners

Exams
Description Length Semester When Set Percentage Comment
Oral Presentation101M30Submission of recorded presentation of drug discovery project
Other Assessment
Description Semester When Set Percentage Comment
Essay1M402000 word project - propose a drug discovery project to a drug company board
Portfolio1M30Participation in a series of problem based online activities (approx. 9)
Assessment Rationale And Relationship

The series of problem based online exercises are set within either a virtual pharmaceutical industry or academia and often have no right or wrong answer. Justification of the approach and choices made by the student will be considered. These assessments links to the skills outcomes of data appraisal and handling and application of learning to own work or research.

The coursework project is designed to assess the ability of the learners to synthesise learning from each topic and construct an overall understanding of the process of drug discovery. It also primarily aims to test the skills learning outcomes of being able to apply the learning to their own research interests or area of work.

The presentation will compliment to the written project; testing the student’s ability to analyse, synthesise and present their completed scientific project to a drug company board.

Reading Lists

Timetable