Postgraduate

Modules

Modules

CHS8008 : Biology of Ageing (E-learning)

Semesters
Semester 1 Credit Value: 20
ECTS Credits: 10.0

Aims

1. To provide a framework to understand why ageing occurs in almost all organisms and why ageing is particularly slow in humans
2. To present details of the essential mechanisms of ageing as a basis to understand how organisms age
3. To inform students on the role of intrinsic and extrinsic stress in ageing
4. To provide a critical platform to judge the efficacy of potential interventions
5. To apply the mechanisms of ageing to the physiological processes in humans and other animals
6. To present details of the development of theories in ageing research
7. To inform students of the current and likely future trends in ageing research

Outline Of Syllabus

This module will cover:


1. Longevity, ageing and the life cycle including the evolutionary theories of ageing
2. Mechanisms of stress and ageing: damage to protein, lipid and DNA molecules; the associated maintenance and repair systems; and the consequences of the accumulation of un-repaired molecular damage.
3. Protein homeostasis
4. Maintenance of telomeres including telomerase; apoptosis and cellular senescence; the role of mitochondria and oxidative stress
5. Use of cell and animal model systems for ageing research
6. The mechanisms of ageing in stem cells
7. Ageing of hormonal systems
8. Ageing of extra cellular matrix
9. Molecular nutrition and its’ role in ageing
10. Female reproductive ageing
11. The role of oxidative stress in ageing
12. The future of ageing research including genetics and the use of systems biology

Teaching Methods

Module leaders are revising this content in light of the Covid 19 restrictions.
Revised and approved detail information will be available by 17 August.

Assessment Methods

Module leaders are revising this content in light of the Covid 19 restrictions.
Revised and approved detail information will be available by 17 August.

Reading Lists

Timetable