Postgraduate

Modules

Modules

CHY8820 : Organic Synthesis for Drug Targets

Semesters
Semester 1 Credit Value: 10
Semester 2 Credit Value: 10
ECTS Credits: 10.0

Aims

To familiarise students with the key strategies for the synthesis of organic compounds; to provide practise in identifying and applying such strategies; to exemplify the principles in the context of the synthesis of drug targets.

Outline Of Syllabus

Workshops
Dr James Knight

A series of 2h workshops to consolidate core understanding of synthetic organic chemistry, reactions and principles and to extend that knowledge to more advanced examples.

Aromatic Chemistry including Rearrangements
Dr DA Fulton

1 The definitions of aromaticity
2 Electrophilic aromatic substitution
3 Electrophilic aromatic substitution reactions of substituted benzenes
4 Synthesis of substituted benzenes; the reactions of benzene diazonium salts
5 Nucleophilic aromatic substitution; the chemistry of benzyne
6 Aromatic oxidations and reductions
7-8 Rearrangement reactions

Heteroaromatic Chemistry
Dr Mike Carroll

1 Aromatic systems containing heteroatoms; introduction and overview
2-4 Membered heteroatromatics containing one heteroatom; pyrroles, furans and thiophenes
5-6 Membered heteroaromatics containing one heteroatom; pyridines
7 Fused heteroaromatics; indoles and quinolines
8 Heteroaromatics containing more than one heteroatom

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Guided Independent StudyAssessment preparation and completion215:0030:002 in-course assignments during Semester 1
Scheduled Learning And Teaching ActivitiesLecture100:305:00Revision for end of semester 1 examination
Guided Independent StudyAssessment preparation and completion11:001:00End of semester 1 examination
Scheduled Learning And Teaching ActivitiesLecture241:0024:00N/A
Guided Independent StudyAssessment preparation and completion215:0030:002 in-course assignments during Semester 2
Guided Independent StudyAssessment preparation and completion100:305:00Revision for end of semester 2 examination
Guided Independent StudyAssessment preparation and completion11:001:00End of semester 2 examination
Scheduled Learning And Teaching ActivitiesWorkshops102:0020:00N/A
Guided Independent StudyIndependent study184:0084:00Background reading and practice past paper examination questions
Total200:00
Jointly Taught With
Code Title
CHY2101Organic Chemistry
CHY3105Advanced Organic Chemistry (Distance Learning)
CHY3108Advanced Organic Chemistry
Teaching Rationale And Relationship

The course involves the introduction of a set of principles which may be applied to the analysis and design of organic synthesis. These principles are addressed in the 24 lectures and are consolidated in seminars (which are spread out over the course) in which problems, each focusing on a particular example, and attempted in advance by the students are discussed. The final series of workshops involve discussion of the application of these principles in the context of total synthesis of drug targets and serve to draw together the various strands of the course. The problem sessions involve working through the answers to a series of synthetic exercises, which are attempted and handed in by the students in advance. This work allows the students to apply the ideas introduced in the lectures and forms part of the assessment of the module.

Assessment Methods

The format of resits will be determined by the Board of Examiners

Exams
Description Length Semester When Set Percentage Comment
Written Examination601A25N/A
Written Examination602A25N/A
Exam Pairings
Module Code Module Title Semester Comment
CHY2101Organic Chemistry1Written exam 1
CHY3105Advanced Organic Chemistry (Distance Learning)2Written exam 2
CHY3108Advanced Organic Chemistry2Written exam 2
Other Assessment
Description Semester When Set Percentage Comment
Essay1M252 x assignments (max length 1000 words)
Essay2M252 x assignments (max length 1000 words)
Assessment Rationale And Relationship

The written paper will consist of problem- oriented questions, some of which focus on a particular principle or set of related principles and some which require a broader analysis. The written exercises allow students to explore a wider range of synthetic problems than in the exam, and also enable them to receive feedback during the course.
This is deemed an appropriate method of ascertaining the level to which the student has understood and assimilated principles introduce in the course and the extent to which they can apply these to unfamiliar situations.

Reading Lists

Timetable