Postgraduate

Modules

Modules

CHY8822 : Drug Metabolism and Toxicology

Semesters
Semester 1 Credit Value: 10
ECTS Credits: 5.0

Aims

To introduce the principles of pharmacokinetics, drug metabolism and toxicology; to understand the importance of optimising these parameters in drug discovery; to understand the chemical basis of drug metabolism and its importance in drug discovery; to equip students with a knowledge and understanding of the mechanism of toxicity of drug molecules and other the environmental toxins

Outline Of Syllabus

Pharmacokinetics and drug metabolism (Professor M Waring)
Principles of pharmacokinetics
Processes and mechanisms of drug metabolism
Selected case studies in drug metabolism

Toxicology (Professor M Waring)
Principles of Toxicology and toxicokinetics
Critical toxicological issues for drug discovery
Allergens and reactive metabolites
Ion channels – hERG and acetyl choline signalling
Carcinogenesis and Oxidative Stress

Teaching Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

Teaching Activities
Category Activity Number Length Student Hours Comment
Guided Independent StudyAssessment preparation and completion12:002:00Alternate assessment
Guided Independent StudyAssessment preparation and completion120:0020:00Revision for alternative end of module assessment
Guided Independent StudyAssessment preparation and completion210:0020:00Written exercises - Structured literature exercise: case study and literature reading
Guided Independent StudyAssessment preparation and completion121:0012:00Online materials via Canvas
Guided Independent StudyIndependent study143:3043:30Independent study
Scheduled Learning And Teaching ActivitiesModule talk30:301:30Live lecture material
Scheduled Learning And Teaching ActivitiesModule talk11:001:00Live lecture material
Total100:00
Jointly Taught With
Code Title
CHY3109Advanced Medicinal Chemistry
CHY3110Advanced Medicinal Chemistry
Teaching Rationale And Relationship

Students acquire knowledge and understanding through online lecture content and live module talks. Problem-solving skills are practiced in module talks and in private study.

Assessment Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

The format of resits will be determined by the Board of Examiners

Other Assessment
Description Semester When Set Percentage Comment
Written exercise1M502 assignments (max 4 pages)
Computer assessment1M50Alternate end of module assessment
Assessment Rationale And Relationship

The alternate assessment will test the student’s knowledge and understanding of the coursework as well as information literacy and presentation skills.

Study Abroad students may request to take their exam before the semester 1 exam period, in which case the format of the paper may differ from that shown in the MOF. Study Abroad students should contact the school to discuss this.

Reading Lists

Timetable