CHY8823 : Theory and Practice of Chemotherapy

Semester 2 Credit Value: 20
ECTS Credits: 10.0


To introduce the basic concepts of the aetiology of cancer and pathogenic disease; to impart an understanding of the host-pathogen relationship, and the concepts of selective toxicity and resistance; to equip students with an understanding of the basic principles of chemotherapy of cancer and infectious disease; to provide an understanding of the molecular mechanisms underpinning the action of anticancer and anti-infective drugs.

Outline Of Syllabus

Cancer Chemotherapy
Dr C Cano

1 Introduction to cancer
2 DNA reactive drugs
3 Antimetabolites
4 DNA Topoisomerase inhibitors
5 Mitotic poisons
6 DNA Repair Enzymes
7 Antiendocrine drugs
8 Current approaches to cancer chemotherapy
9 New thearapies: Targetting receptor tyrosine kinase signalling
10 Kinase inhibitors case studies

Chemotherapy of Infectious Diseases
Professor Bernard Golding

1 Introduction and historical overview
2 Principles of antimicrobial chemotherapy
3 Antibacterial agents – Penicillin and related β-lactam
4 Antibacterial agents – Glycopeptides, quinolones, and oxazolidinones
5 Antifungal agents – Polyenes and azoles
6 Antifungal agents – Azoles and other antifungals
7 Metronidazole
8 Malaria and its treatment
9 Antiviral chemotherapy
10 Acyclovir and maraviroc

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Guided Independent StudyAssessment preparation and completion136:0036:002 in-course assignments
Guided Independent StudyAssessment preparation and completion200:5016:40Revision for end of semester examination
Guided Independent StudyAssessment preparation and completion12:002:00End of semester examination
Scheduled Learning And Teaching ActivitiesLecture201:0020:00N/A
Guided Independent StudyIndependent study1125:20125:20Background reading and practice past paper examination questions
Jointly Taught With
Code Title
CHY3109Advanced Medicinal Chemistry
CHY3110Advanced Medicinal Chemistry
Teaching Rationale And Relationship

Students acquire an understanding of the subject through attendance and participation in lectures. An understanding of the topics is reinforced by problem solving, and critical background reading of the scientific literature. The literature assignment will develop skills in reading, understanding and assimilating new information, and subsuming the acquired knowledge into a concise written review.

Assessment Methods

The format of resits will be determined by the Board of Examiners

Description Length Semester When Set Percentage Comment
Written Examination1202A50N/A
Exam Pairings
Module Code Module Title Semester Comment
CHY3109Advanced Medicinal Chemistry2N/A
CHY3110Advanced Medicinal Chemistry2N/A
Other Assessment
Description Semester When Set Percentage Comment
Essay2M502 x assignments - equally weighted, 1500 words for each with labelled diagrams and figures (including reaction schemes).
Assessment Rationale And Relationship

The formal examination will test the student's acquisition and understanding of the lecture/seminar material; written assessments will assess student's conceptual understanding in the key subject areas.

Reading Lists