MMB8008 : Cell Cycle Control and Cell Signalling in Health and Disease
- Offered for Year: 2019/20
- Module Leader(s): Dr Jun-yong Huang
- Lecturer: Dr Gabriele Saretzki, Professor Jonathan Higgins, Professor Fiona Oakley, Professor Penny Lovat, Professor Brendan Kenny, Professor Loranne Agius, Professor Mary Herbert, Dr Richard Daniel, Dr Catherine Arden, Professor Neil Perkins, Dr Josana Rodriguez Sanchez
- Owning School: FMS Graduate School
- Teaching Location: Newcastle City Campus
|Semester 1 Credit Value:||20|
This module is designed to introduce students to the fundamental areas of cell biology especially control of the cell cycle and cell signalling pathways using various model organisms. Students will gain both a thorough understanding of the regulation of some key signalling pathways and some essential mechanisms of cell division with a wide range of cellular responses, and how the altered activities of critical components of these pathways may result in diseases such as diabetes, liver fibrosis, and cancer.
Outline Of Syllabus
This module covers:
1. The fundamental biology of cell cycle control in different model organisms (bacteria, Drosophila, Caenorhabditis elegans, Saccharomyces cerevisiae and human culture cell lines). It will cover cell division control in mitosis and meiosis, establishment of cell polarity, apoptosis, the functions of the telomere and telomerase, the NF-kB signalling pathway in the regulation of cell proliferation and survival, and in the DNA damage response, and their impact on health and diseases. These will be covered in the light of the lecturers’ current research interests.
2. Some key intracellular signalling pathways. This will cover the following topics: how epigenetic signalling impacts on histone modifications and changes the configuration of chromatin during cell division, the role of NF-kB in regulating the transcription, gene expression and immune response to infection, stress, cytokines, etc., the role of glucose metabolism, insulin signalling and diabetes, the impairment of the mechanism of cell death in disease, and how the signalling pathways related to EPEC alter the biology of differentiated epithelia encompassing in health and diseases.
|Scheduled Learning And Teaching Activities||Lecture||18||1:00||18:00||Lectures|
|Guided Independent Study||Assessment preparation and completion||1||30:00||30:00||Preparation and Submission of 2000 word Essay|
|Guided Independent Study||Assessment preparation and completion||1||50:00||50:00||Revision for Examination|
|Guided Independent Study||Assessment preparation and completion||1||30:00||30:00||Preparation of Presentation and Presentation|
|Scheduled Learning And Teaching Activities||Small group teaching||4||1:00||4:00||Seminars/Tutorials|
|Guided Independent Study||Reflective learning activity||1||18:00||18:00||Reading and Reflective Learning|
|Guided Independent Study||Independent study||1||50:00||50:00||Preparing Notes from Lectures and Reading|
Teaching Rationale And Relationship
Knowledge and understanding are gained from the lectures and seminar/tutorials. Intellectual skills are developed in the tutorials and by the coursework. Key (transferable skills – communication, literacy, critical appraisal) are developed during the tutorials and by the coursework and practiced in the oral presentation and written work (essay).
The format of resits will be determined by the Board of Examiners
|Prof skill assessmnt||1||M||20||Oral presentation|
Assessment Rationale And Relationship
Knowledge and understanding are assessed in the written examination and the 2000 word essay. Skills in writing and literacy, sourcing materials, critical appraisal and use of IT are all part of the 2000 word essay. Presentation skills are assessed in the short oral presentation and once again IT, literacy active learning and critical appraisal are part of this exercise.