MMB8020 : Scientific Basis of Neurological Disorders
- Offered for Year: 2019/20
- Module Leader(s): Professor Robert Lightowlers
- Demonstrator: Dr Gavin Clowry
- Lecturer: Professor Nicola Pavese, Professor Raj Kalaria, Professor Andrew Trevelyan, Dr Hugo De Sao Jose Martinho De Oliveira, Dr Timothy Williams, Dr Duddy Duddy, Professor Robert Taylor, Dr Amy Reeve, Dr Michael Firbank, Professor Bobby McFarland, Professor Evelyne Sernagor
- Owning School: FMS Graduate School
- Teaching Location: Newcastle City Campus
|Semester 1 Credit Value:||20|
The module aims are to:
1. acquaint students with the clinical presentations of some important neurological disorders
2. develop understanding of key aspects of cellular and molecular neuroscience in the context of their relevance to those disorders
3. introduce principles and practice of a range of modern methods for investigating the nervous system
4. describe the main ways in which nerve cells respond to insult and injury
5. examine the latest hypotheses to explain the symptoms and consequences of neurological disorders
6. explore possible ways in which neurological disorders might be treated in the future
This module introduces the basic clinical aspects of many neurological disorders and details our present understanding of the molecular aetiology that underlies these disorders. It blends clinical lectures given by practicing clinicians and basic science lectures from researchers involved in unravelling the molecular basis of these disorders.
Outline Of Syllabus
The module introduces the students to several aspects of neurology and neurological research that are critical to their understanding of the subject. This involves basic neuroanatomy, neurophysiology, neurological examination and neuroimaging. The module then focuses on several groups of disorders – stroke, movement disorders, dementias, eye disease, autoimmunity and mitochondrial disease. Clinicians working in these areas present the basic clinical aspects and research scientists explain the molecular dysfunctions that can lead to these diseases. Finally, the module leader gives a brief overview of the course with emphasis on general themes that run through all the neurological disorders that have been discussed.
|Guided Independent Study||Assessment preparation and completion||1||30:00||30:00||Critical Evaluation|
|Guided Independent Study||Assessment preparation and completion||1||20:00||20:00||Preparation for MCQ test|
|Scheduled Learning And Teaching Activities||Lecture||24||1:00||24:00||Lectures|
|Guided Independent Study||Reflective learning activity||1||26:00||26:00||Additional Reading & Reflective Learning|
|Guided Independent Study||Independent study||1||50:00||50:00||Revision for Examination|
|Guided Independent Study||Independent study||1||50:00||50:00||Preparing Notes from Lectures & Reading|
Teaching Rationale And Relationship
Many neurological disorders diseases have dramatic debilitating effects and cause major stress within the family. Understanding of these diseases and their causes requires knowledge of the basic principle of nerve cell biology. This module will introduce students to these principles in the context of several clinically important neurological disorders and will show how defects at the cellular and molecular levels can give rise to the features of the disorders at clinical presentation. The diseases selected for study will include both inherited and acquired conditions that affect both nerve cell function and survival. The module takes advantage of the wealth of neuroscience experience in Newcastle at both scientific and clinical levels.
This will be a mainly didactic module, with students being introduced to neurological disorders in man and the associated defects in cells and molecules. They will also write an extended essay in which they will apply the approach to understanding disease illustrated by the lectures to an additional disease. This will provide them with the opportunity to practice their analytical and written skills. In addition to the 30 hrs of formal teaching, the students will be expected to spend a minimum of 170 hrs in self-teaching following the guidelines identified in the lectures.
The format of resits will be determined by the Board of Examiners
|Written Examination||60||1||A||60||One question answered from a choice of three|
Assessment Rationale And Relationship
The examination, set at the end of the formal lectures, will be designed to test the knowledge and understanding of the students and their ability to communicate in writing complex ideas in a coherent fashion. The MCQs test knowledge and understanding and the critical evaluation critical analysis and understanding. In addition the written assessment test writing skills, ability to source and present information using a computer.