MMS8102 : Human Health and the Impact of Microbial Genomics
- Offered for Year: 2019/20
- Module Leader(s): Dr Phillip Aldridge
- Lecturer: Dr Anjam Khan, Dr Judith Hall, Dr Elisabeth Lowe, Professor Robert Hirt, Dr Nicholas Jakubovics, Dr David Bolam
- Owning School: FMS Graduate School
- Teaching Location: Newcastle City Campus
|Semester 2 Credit Value:||20|
The aim of this module is to provide the student with a critical understanding of how microbial genomes (viral, bacterial and eukaryotic) are impacting:
1) our appreciation of host-microbe interactions.
2) the beneficial or detrimental outcomes of host-microbe interactions have with respect to human health.
The aim specifically reflects the following:
• the increasing availability and use of microbial genomes for diagnosis and treatment.
• the increasing availability of metagenomic data and the resulting perception change of the microflora associated with us.
• the increasing availability of bioinformatics tools to analyze and visualize large next generation sequencing data sets.
• the impact of microbial resistance to chemotherapeutic drugs.
• the impact genomics is having on the development of novel diagnostic tools (e.g. point of need, rapid).
• the importance of host recognition of microbes
• microbial evasion of host defense mechanisms.
Outline Of Syllabus
This module will cover:
• The microbiota and its role in defense against disease
• Prokaryote, eukaryote and viral microbes: their genomes, replication and population genetics
• Genomic comparisons of microbes in the context of outbreaks and transmissions in hospitals and the community
• Anti-infective drug action and how genomics impacts monitoring of drug resistance
• Genomic evidence of individual susceptibility to specific infections
• Role of genomics in infectious disease diagnosis, prognosis, drug selection, resistance, monitoring, epidemic control, drug research.
• The microbiota that lives with us
• clinical perspective of managing host-microbe interactions
• The role played by innate immune defences in host-microbe interactions
|Guided Independent Study||Assessment preparation and completion||1||20:00||20:00||Preparation of open book assessment|
|Scheduled Learning And Teaching Activities||Lecture||12||2:00||24:00||N/A|
|Guided Independent Study||Directed research and reading||1||128:00||128:00||Independent study, including preparation for exam|
|Scheduled Learning And Teaching Activities||Practical||1||6:00||6:00||In silico data analysis workshop|
|Scheduled Learning And Teaching Activities||Small group teaching||2||1:00||2:00||Research seminars from clinical lecturers within the Newcastle NHS trust|
|Guided Independent Study||Project work||1||20:00||20:00||Data analysis report preparation|
Teaching Rationale And Relationship
This module will exploit direct presentation (lectures) of the course material and guided study of further material through the blackboard portal to learn about Human health and our microbes, our reaction to microbes via both arms of the immune system, current technologies for analysing and extracting relevant information from microbial genomes, how the information can be used to enhance existing clinical techniques, and how it can be used to inform treatment and outbreak control. Students will be encouraged to focus on specific topics/tasks in preparation for the planned activities.
Small group teaching with linked computer-based practicals to introduce students to techniques for analysing and extracting data from microbial genomes, in relation to drug resistance phenotypes, virulence factors, and diagnostic and epidemiological tools. The time allocated to independent learning will be used to encourage the students to reflect more broadly on the evolving use of microbial genome sequence data to assess the impact of microbes on our health within clinical and community settings.
The format of resits will be determined by the Board of Examiners
|Written Examination||60||2||M||60||Essay based choice of 1 question from 3|
|Written exercise||2||M||20||Short answer questions, open book 5 days from being given to submission. 5 questions, 200 word limit for each.|
|Report||2||M||20||Data analysis report, linked to in silico practical. Word limit: 1500|
Assessment Rationale And Relationship
Three summative assessments will generate the framework to assess the learning outcomes, aimed at reinforcing core knowledge on microbes, microbial genomics and their impact on human health as reflected in the Intended Knowledge Outcome. These assessments will allow the student to ensure they have a full grasp of the core knowledge, the written summaries and help them to develop critical assessment of genomics and genomic techniques in the context of human health and clinical practice. A key aspect of all three assessments is to provide valuable opportunities to receive feedback on writing skills.
The main assessment (60%) will be a written exam where 1 essay answer from a choice of 3 will be assessed. The proposed essay titles will be cross cutting the themes taught to achieve the knowledge and skill outcomes. The first of two in-course assessments (20%) will be an open book assessment requiring the students to return detailed answers to a range of short answer questions linked to the range of topics taught across the module. The open book format will allow the students to use the time given as directed, independent learning while also providing feedback on their ability to write concisely.
The second in-course assessment (20%) will be a data analysis report based on genomic data analyses interlinked to the bioinformatics tools and analysis to be used in the in silico practical. This will assess both understanding and application of bioinformatic methods, as well as their potential to evaluate the impact of host-microbe interactions on human health and their use in clinical practice. Students will be required to make and justify judgement concerning the choice of analytical platforms and methods, and the most appropriate methods for validation. This will assess learning outcomes in a format that reflects the diversity and complexity of current clinical practice.