Postgraduate

Modules

Modules

CHY8836 : Synthetic Methodology for Drugs

Semesters
Semester 1 Credit Value: 20
ECTS Credits: 10.0

Aims

To familiarise students with the key synthetic methods used to prepare critical functionality in drug molecules.

Outline Of Syllabus

Chemical structure of organic compounds and the resulting physical properties
The synthesis and reactivity of diverse carbonyl group functionality
Aliphatic nucleophilic substitution reactions e.g. SN1 and SN2
Elimination reactions e.g. E1 and E2
Structure and reactivity (e.g. SEAr, SNAr) of aromatic and heteroaromatic compounds
Redox chemistry of selected functionality
Explanation of selectivity and reactivity based on mechanistic rationale

Teaching Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

Teaching Activities
Category Activity Number Length Student Hours Comment
Structured Guided LearningLecture materials361:0036:00Online via Canvas - Course content in Lecture format and revision sessions
Guided Independent StudyAssessment preparation and completion210:0020:002 x peer assessed exercises
Guided Independent StudyAssessment preparation and completion130:0030:00Written alternate assessment
Guided Independent StudyDirected research and reading68:0048:00Background reading for coursework assignments
Structured Guided LearningAcademic skills activities121:0012:00Online via Canvas - Workshops and feedback on Problem Sheets
Guided Independent StudyIndependent study154:0054:00Revision for end of module assessments
Total200:00
Teaching Rationale And Relationship

The online lectures students learn concepts essential for the preparation of drug molecules, encompassing both synthetic and mechanistic principles. The online workshops allow practice of these methods.

Assessment Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

The format of resits will be determined by the Board of Examiners

Other Assessment
Description Semester When Set Percentage Comment
Prob solv exercises1M302 x Peer assessed exercises
Written exercise1M70Alternate written assessment
Assessment Rationale And Relationship

The alternate assessment in Semester 1 will test the students’ knowledge and understanding of the content of this module in the context of both synthetic and mechanistic chemistry. Two Peer Assessments will be set during Semester 1 to determine progress during the Module.

Reading Lists

Timetable