Stiefel GlaxoSmithKline

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Stiefel is the specialist dermatology company within GlaxoSmithKline (GSK), a global healthcare group. Stiefel develops, manufactures and markets consumer healthcare and pharmaceutical products. They worked with Newcastle University's Institute of Cellular Medicine on this KTP.

The Business Need

Atopic eczema is a chronic, inflammatory skin condition associated with epidermal barrier dysfunction. There is a significant unmet clinical need for safe and effective second line treatments for patients with moderate to severe atopic eczema. The Institute of Cellular Medicine possesses expertise in atopic eczema research and in vitro models of skin disease.

Company Benefits

“Newcastle University have provided expertise in 3D equivalent models which has allowed the Company to take the compound to clinical trials. We are now in a position to use the knowledge to adapt to other skin diseases.”

- Dr Michael Donaldson, Drug Discovery and Research Manager, Stiefel GSK

  • Living Skin Equivalent (LSE) model developed for clinical testing
  • Cappability to apply LSE model to other skin diseases
  • Staff training programmes established
  • Forged valuable links with the University
  • Publication in high quality journals increases reputation

Academic Benefits

“This KTP has resulted in rapid progression from proof of concept testing in human skin equivalent models to product development and a phase one trial of a product designed in use to atopic eczema patients.”

- Professor Nick Reynolds, Institute of Cellular Medicine, Newcastle University

  • Three academic papers published
  • Extensive further collaboration with Stiefel GSK
  • Valuable research links with partners in dermatology industry created
  • Quoted in the REF as an exemplar of academic and pharma collaboration
  • Wider societal health impacts

Associate Benefits

“The KTP Associate is now being employed by GSK and will be working to further embed the techniques used when working with the Living Skin Equivalent model and apply these to other skin programmes .”

- Professor Nick Reynolds, Institute of Cellular Medicine, Newcastle University

  • Membership of European Society for Dermatological Research
  • Gained Management qualification
  • Accepted continuing employment to further embed LSE model


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