BGM2057 : Medical genomics: from DNA to disease
- Offered for Year: 2019/20
- Module Leader(s): Dr Katarzyna Pirog
- Lecturer: Dr Simon Bamforth, Dr Michael Jackson, Professor John Sayer, Dr Louise Reynard, Dr Colin Miles, Dr Mauro Santibanez Koref, Dr Joanna Elson, Professor Lyle Armstrong, Dr Ian Wilson, Professor Heather Cordell
- Owning School: Biomedical Sciences
- Teaching Location: Newcastle City Campus
|Semester 2 Credit Value:||20|
1) To describe in detail the organisation of the human genome, including an overview of human variation and major projects investigating it.
2) To consider mechanisms for regulating gene expression and experimental approaches for studying gene expression.
3) To provide an overview of model organisms used in biomedical research and to consider approaches used to generate mouse models.
4) To consider different approaches for identifying genes underlying human genetic disorder and characterizing their functions.
Outline Of Syllabus
This module moves from describing the organisation of the human genome, through gene regulation and expression to methods and approaches for identifying genes involved in human genetic disorder and characterising their functions.
The module syllabus will contain:
-a detailed description of the organisation of the human genome and an introduction to how this influences mutation, variation, and function
-exploration of regulatory mechanisms controlling gene expression and approaches to studying expression patterns
-an overview of model organisms and classical and recent approaches for generating mouse models
-approaches for studying human genetic disorders will be discussed, covering some of the methods used to identify the underlying causative genes and what is known of gene function.
|Guided Independent Study||Assessment preparation and completion||1||55:00||55:00||Preparation for in-course assessment and exams|
|Scheduled Learning And Teaching Activities||Lecture||19||1:00||19:00||Used as primary method of knowledge transfer. Further reading and self-directed learning directed.|
|Guided Independent Study||Assessment preparation and completion||2||4:30||9:00||The students will prepare for the practicals using references provided by the practical leaders.|
|Scheduled Learning And Teaching Activities||Practical||2||3:00||6:00||Practicals will be computer-based and the students will gain both knowledge and skills.|
|Scheduled Learning And Teaching Activities||Small group teaching||1||1:00||1:00||Seminar will be on how to write an essay and will support students' preparation for the timed essay.|
|Guided Independent Study||Reflective learning activity||40||1:00||40:00||Writing notes and reflecting on lectures based on text books and RECAP lectures.|
|Guided Independent Study||Reflective learning activity||1||70:00||70:00||N/A|
Teaching Rationale And Relationship
Lectures will provide the majority if the knowledge base. The lectures should stimulate the students to reflect and read further from textbooks and references highlighted during the lectures. The seminar will support the students in developing skills for analysing research papers. The practicals enable the students to navigate online resources and synthesise and apply the knowledge gained.
The format of resits will be determined by the Board of Examiners
|Written Examination||120||2||A||80||30 minutes EMI, 90 minutes essay writing (two from a choice of four).|
|Essay||2||M||10||In course assessment, 1 hr in length|
|Computer assessment||2||M||10||In course assessment|
Assessment Rationale And Relationship
The examination provides evidence of knowledge and understanding of the topic. The timed essay tests application of knowledge, understanding and critical evaluation skills. The computer-based assessment tests understanding, ability to navigate online resources and to synthesise and apply the knowledge gained.