BGM3062 : Genetics of Development and its Disorders
- Offered for Year: 2018/19
- Module Leader(s): Professor John Sayer
- Lecturer: Dr Gavin Clowry, Dr Colin Miles, Dr Heiko Peters, Dr Katarzyna Pirog
- Owning School: Biomedical Sciences
- Teaching Location: Newcastle City Campus
|Semester 1 Credit Value:||10|
The module aims are:
• to provide an overview of vertebrate development
• to describe in more detail the development of several organ systems.
• to identify key developmental processes and the genes and genetic pathways that are involved
• to consider how the same gene families are important in the development of multiple organs and that there are processes that are common to the development of many organs.
• to consider the role of developmental genes in genetic disorders
Outline Of Syllabus
Many human disorders have a developmental origin and knowledge of the processes underpinning development is an important step towards understanding gene function and disease mechanisms. As the normal and abnormal development of a range of model organisms is analysed as part of studies of gene function, this module will include information from several species, although it is focused on vertebrate development.
The module will provide an overview of key concepts in vertebrate development and a framework for understanding developmental research and its role in underpinning research on human genetic disorders.
The module syllabus will include:
• establishment of the basic body plan
• establishment and breaking of symmetry
• development of organs derived from endoderm, mesoderm and ectoderm covering their patterning and organization from stem cells to genetic disorders. Examples might be gut, kidney, limb, the hematopoietic system and brain.
|Guided Independent Study||Assessment preparation and completion||12||1:00||12:00||Generation of research paper|
|Scheduled Learning And Teaching Activities||Lecture||15||1:00||15:00||N/A|
|Scheduled Learning And Teaching Activities||Workshops||1||3:00||3:00||Working through online expression/development database|
|Scheduled Learning And Teaching Activities||Workshops||1||1:00||1:00||workshop/seminar on ethics|
|Guided Independent Study||Independent study||69||1:00||69:00||N/A|
Teaching Rationale And Relationship
Lectures will provide the majority of the knowledge base, and should stimulate the students to reflect and do further reading (independent study). Workshops 1) will expose the students to ethical concerns surrounding use of animals and human tissues in research 2) provide the key foundation for generation of the in course assessed research paper which they will complete as guided independent study.
The format of resits will be determined by the Board of Examiners
|Written Examination||90||2||A||80||One essay question to be answered from a choice of two (60 mins 70% of the marks) compulsory short answer questions (30 mins 30%)|
|Research paper||1||M||20||Arising from use of developmental databases. Written exercise, 1,500 words maximum'|
Assessment Rationale And Relationship
The examination provides evidence of knowledge and understanding of the topic. The essay enables the students to show their depths of understanding of one aspect of the module while the short answer questions enable knowledge and understanding over the breadth of the module to be demonstrated.
The research paper tests ability to synthesize data from online resources, will further understanding of the topic, and critical evaluation skills.