Undergraduate

modules

Modules

BGM3065 : Biochemistry of Cancer and Chronic Diseases

Semesters
Semester 1 Credit Value: 20
ECTS Credits: 10.0

Aims

Through lectures and seminars this module aims to;

• provide an understanding of the biochemistry and clinical aspects of a number of chronic human diseases
• explain how knowledge of the biochemistry of a disorder can be used to develop rational drug design for its treatment
• provide an opportunity for students to further develop their written skills and critical analytical skills.
• inform students about the genetic and molecular basis of cancer and its treatment.
• introduce current technologies used in cancer detection, diagnostics and molecular pathology and allow students to explore how these techniques are being applied to advance our understanding of cancer.
• facilitate an understanding of the problems associated with cancer treatments.

Outline Of Syllabus

The biochemistry and clinical aspects of a number of chronic human diseases will be explored to explain how knowledge of the biochemistry of a disorder can be used to develop rational drug design for treatment. Topics include:
• biochemistry of trace metal sensing and its relevance to disease
• core mechanisms of metal-homeostasis (metallochaperones, metal-sensing transcriptional and translational regulators, metal-specific transporters and storage proteins) and provide some examples of the ways in which these processes fail in disease.
• NF-kB signalling in health and disease
• background to the biochemistry and molecular biology of cancer
• cancer as a multi-process genetic disease
• role of oncogenes and tumour suppressor genes
• roles of failures in the DNA repair mechanisms in causing cancer
• factors that lead to metastasis
• experimental genetic models of tumour development
• methods of anticancer treatment and the problems of drug resistance

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Scheduled Learning And Teaching ActivitiesLecture271:0027:00
Scheduled Learning And Teaching ActivitiesSmall group teaching31:003:00Seminars
Scheduled Learning And Teaching ActivitiesWorkshops13:003:00Oral Presentations
Guided Independent StudyIndependent study1167:00167:00
Total200:00
Teaching Rationale And Relationship

Lectures will provide the students with essential information to achieve learning outcomes. Seminars will provide additional information and develop the student’s critical skills. The essay feedback seminar will help students to further their written skills and their ability to interpret scientific literature. The workshop will be student (assessed) presentations. Independent study will enable students to widen their knowledge through reading recommended references and journal articles. The seminars focus on major topics covered in the lectures, providing in-depth knowledge of the topics and opportunities for students to discuss topic areas where they require additional information or clarification is required.

Assessment Methods

The format of resits will be determined by the Board of Examiners

Exams
Description Length Semester When Set Percentage Comment
Written Examination1202A802 essay questions from a choice of 4
Exam Pairings
Module Code Module Title Semester Comment
BGM3024The Molecular Basis of Cancer2Exams to be scheduled at the same time. Shared lectures/topics will allow the same questions to be used by these 2 modules
BMS3012Cancer Biology and Therapy2Exams to be scheduled at the same time. Shared lectures/topics will allow the same questions to be used by these 2 modules
Other Assessment
Description Semester When Set Percentage Comment
Essay1M101500 words
Prof skill assessmnt1M10Oral Presentations (10 minutes including questions)
Assessment Rationale And Relationship

The examination primarily assesses students' knowledge and understanding. The essay, written after a tutorial discussion, will develop the students' ability to assimilate and analyse complex scientific information and to develop their written skills. Oral presentations develop students’ ability to distil information into a short form and to enhance their skills in platform presentation.

Reading Lists

Timetable