BIO8045 : Genetically Engineered Organisms: Food, Pharmaceutical & Industrial Sectors
- Offered for Year: 2018/19
- Module Leader(s): Professor Angharad MR Gatehouse
- Lecturer: Dr Paul Bilsborrow, Dr Timothy Boswell, Dr Jon Marles-Wright
- Owning School: Natural and Environmental Sciences
- Teaching Location: Newcastle City Campus
|Semester 2 Credit Value:||20|
• To ensure that students are informed of contemporary aspects of GEOs in the Food, Pharmaceutical and Industrial sectors and are able to evaluate their potential critically.
• To illustrate how transgenic and cloning technologies lead to practical, including commercial, applications.
• To inform students of current and pipeline crops and traits that have been derived using recombinant DNA technology for food and industrial products.
• To evaluate safety and environmental issues of transgenic crops.
• To evaluate the impact of the discovery of animal cloning on animal reproduction, transgenesis and regenerative medicine.
• To consider the social and ethical implications of developments in plant and animal biotechnology.
• To enhance students’ critical appraisal skills through the usage of primary and secondary literature and debate.
Outline Of Syllabus
This module is designed to provide an introduction to the latest developments of recombinant DNA technology in the Food, Biomedical, Pharmaceutical and Industrial Sectors. It will cover the role of genetically engineered crops in agricultural systems, which have already been commercialised/in the pipeline, specifically those developed for tolerance/resistance to stress, as well as the use of transgenic crops as ‘biofactories’. The module will also consider in depth the environmental impact relating to the wide scale growing of such crops and the safety assessment of GEOs for human and animal consumption. Consideration of animals will include potential use of transgenic insects for crop protection strategies, the use of transgenic and cloned animals for food production and agriculture, and use of transgenic animals for producing pharmaceutical proteins. Cloning applications will extend into human medical applications in the context of regenerative medicine, including consideration of induced pluripotent stem cells The module will also address social and ethical implications of genetic modification and cloning technologies.
Applications of Plant Genetic Engineering
• Resistance to biotic stress (pests and diseases)
• Resistance to abiotic stress (environmental)
• Improved nutritional qualities
The Safety Assessment of Transgenic Plants
• Safety studies for foods, feeds and processed fractions
• Ecological testing and evaluation of genetically modified crops
Environmental and Public Consequences of Biotechnology in Agriculture
• Effects of transgenic plants on non-target organisms
• Gene flow from transgenic organisms into “natural” populations
• Public perception of transgenic organisms in Agriculture
Applications of Transgenesis in Fish and Farm Animals
• Development of transgenic fish for commercial food production and environmental monitoring
Potential of Transgenic Farm Animals for Food Production and Nutritional Modification
• Transgenic farm animals: applications for human medicine
Applications of Transgenesis and Paratransgenesis in Insects
• Medical Biotechnology (for control of insect vectored diseases)
• Industrial Biotechnology (production of valuable commercial products)
• Agricultural Biotechnology (in crop protection)
Impact and Development of Animal Cloning Technology
• Dolly the sheep and development of nuclear transfer technology
• Applications for reproductive cloning
• Use of nuclear transfer to refine methods for transgenesis in farm animals
• Application of therapeutic cloning to regenerative medicine
Ethics of Cloning and Genetic Modification
• Seminar on application of ethical principles to a relevant example of animal or human biotechnology
|Guided Independent Study||Assessment preparation and completion||1||20:00||20:00||Case Study|
|Guided Independent Study||Assessment preparation and completion||1||36:00||36:00||2500 word essay|
|Scheduled Learning And Teaching Activities||Lecture||6||2:00||12:00||Seminars|
|Scheduled Learning And Teaching Activities||Lecture||24||1:00||24:00||N/A|
|Guided Independent Study||Assessment preparation and completion||1||15:00||15:00||Ethics seminar report|
|Guided Independent Study||Assessment preparation and completion||1||12:00||12:00||Lab Report|
|Guided Independent Study||Directed research and reading||24||1:00||24:00||Completion of post-lecture directed reading|
|Guided Independent Study||Independent study||24||1:00||24:00||Lecture follow-up|
|Guided Independent Study||Independent study||1||33:00||33:00||Study of lectures, ReCap, Blackboard etc.|
Teaching Rationale And Relationship
The lectures will both review background and provide state-of-the-art information on the technology; the module will also be informed by current research being carried out at Newcastle. The lectures will also provide key concepts and developments with illustrative examples. Key aspects of the lecture material will be covered in greater depth in the seminars.
The format of resits will be determined by the Board of Examiners
|Essay||2||M||60||2500 word report|
|Written exercise||2||M||30||Case study of genetic modification (1500 words)|
|Written exercise||2||M||10||Ethics seminar report (1000 words)|
Assessment Rationale And Relationship
The essay will enable students to explore research developments in more depth in the style of a scientific review article. This is complimented by a directed case study which allows students to focus on a practical application of genetic engineering of their own choosing. The ethics seminar report requires students to formulate a logical argument within an ethical framework.