CHY3110 : Advanced Medicinal Chemistry

Semester 1 Credit Value: 10
Semester 2 Credit Value: 10
ECTS Credits: 10.0


To introduce the principles of toxicology and drug and toxin metabolism; to equip students with a knowledge and understanding of the mechanism of toxicity of a range of chemicals encountered in the environment and workplace
To introduce the basic concepts of the aetiology of cancer and pathogenic disease; to impart an understanding of the host-pathogen relationship, and the concepts of selective toxicity and resistance; to equip students with an understanding of the basic principles of chemotherapy of cancer and infectious disease; to provide an understanding of the molecular mechanisms underpinning the action of anticancer and anti-infective drugs
To provide students with a thorough understanding of catalysis in the context of biological reactions and the roles of cofactors and metal ions in biomolecule structure and function.

Outline Of Syllabus

Principles and Selected Topics
Dr C Bleasdale

Introductory Workshop
Principles of Toxicology
Oxidative Stress
Marine Toxins
Forensic Toxicology

Metabolism and Selected Topics
Professor BT Golding

Introductory Workshop
Drug Metabolism: Principles
Drug Metabolism: Case Studies
Industrial Toxicants

Basic Principles of Enzymology
Dr C Cano

Overview of the role of amino acid side-chains, metal ions and coenzymes in catalysis
Characteristics of enzymes: stability, substrate specificity, stereospecificity, catalytic groups, factors affecting catalysis, enzyme kinetics
Model systems for enzymes (probing proximity effects, solvation, strain), acid-base and nucleophilic catalysis
Overview of selected enzyme mechanisms including those with no cofactor/metal (e.g. glutathione transferases)
Redox cofactors
Small molecule activation by non-metallic cofactors
Radical enzymes

Cancer Chemotherapy
Dr C Cano

Introduction to cancer
DNA reactive drugs
DNA Topoisomerase inhibitors
Mitotic poisons
DNA Repair Enzymes
Antiendocrine drugs
Current approaches to cancer chemotherapy
New thearapies: Targetting receptor tyrosine kinase signalling
Kinase inhibitors case studies

Chemotherapy of Infectious Diseases
Professor M Waring

Introduction and historical overview
Principles of antimicrobial chemotherapy
Antibacterial agents – Penicillin and related β-lactam
Antibacterial agents – Glycopeptides, quinolones, and oxazolidinones
Antifungal agents – Polyenes and azoles
Antifungal agents – Azoles and other antifungals
Malaria and its treatment
Antiviral chemotherapy
Acyclovir and maraviroc

Revision Seminars x 3

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Guided Independent StudyAssessment preparation and completion12:002:00End of Semester 2 Examination
Guided Independent StudyAssessment preparation and completion12:002:00End of Semester 1 Examination
Scheduled Learning And Teaching ActivitiesLecture401:0040:00N/A
Guided Independent StudyAssessment preparation and completion111:0011:00Revision for end of semester 2 examination
Guided Independent StudyAssessment preparation and completion111:0011:00Revision for end of semester 1 examination
Guided Independent StudyIndependent study1134:00134:00Background reading and practise past paper examination questions
Jointly Taught With
Code Title
CHY3109Advanced Medicinal Chemistry
CHY8822Drug Metabolism and Toxicology
CHY8823Theory and Practice of Chemotherapy
Teaching Rationale And Relationship

Students acquire an understanding of the subject through attendance and participation in lectures. An understanding of the topics is reinforced by problem solving, and critical background reading of the scientific literature.

Assessment Methods

The format of resits will be determined by the Board of Examiners

Description Length Semester When Set Percentage Comment
Written Examination1201A50N/A
Written Examination1202A50N/A
Exam Pairings
Module Code Module Title Semester Comment
CHY3109Advanced Medicinal Chemistry1N/A
CHY8822Drug Metabolism and Toxicology1N/A
CHY8823Theory and Practice of Chemotherapy2N/A
Assessment Rationale And Relationship

The examinations will assess the student's knowledge and understanding of the basic principles of the subject.

Study Abroad students may request to take their exam before the semester 1 exam period, in which case the format of the paper may differ from that shown in the MOF. Study Abroad students should contact the school to discuss this.

Reading Lists