Undergraduate

modules

Modules

CHY3305 : Advanced Inorganic Chemistry (Distance Learning)

Semesters
Semester 1 Credit Value: 10
Semester 2 Credit Value: 10
ECTS Credits: 10.0

Aims

To introduce the fundamental principles and reactions of organometallic chemistry; to introduce concepts of homogeneous catalysis; to demonstrate the diverse chemistry of the s- and p-elements; to introduce inorganic aspects of biological systems and metals in biomedicine

Outline Of Syllabus

Organometallic Chemistry
Dr S Doherty

Background and introduction
The 18-Electron rule
Important ligand types; carbonyl (bonding and binary carbonyls)
Pi-ligands, hydrides, phosphines
The synthesis of organometallic compounds
Organometallic reaction mechanisms 1. Reaction at the metal: ligand substitution, oxidative addition and reductive elimination
Organometallic reaction mechanisms 2: Reactions involving the ligand: migratory insertion, reductive elimination and nucleophilic additions and abstractions
Transition metal carbene complexes: synthesis, structure and reactivity
Homogeneous catalysis: an introduction

Comparative Main Group Chemistry
Dr KJ Izod

General principles. Complexes of the s-elements: macrocycles and the macrocyclic effect, alkalides and electrides
Organometallics of the electropositive metals: an introduction to electron-deficient compounds
More electron-deficient compounds: boranes and carboranes, Zintl ions
Low oxidation states of the p-block elements (groups 13 and 14)
E=E bonds (groups 14 and 15); synthesis and reactions. Phosphorus (V) ylides and related compounds
E=E’ bonds – stability, synthesis and reactions

Bioinorganic Chemistry
Professor A Houlton

An introduction to bioinorganic chemistry; the essential metals, metal ion overload-deficiency and treatments.
An introduction to metalloproteins. Protein structure, metal ion binding groups, protein function and role of metal ions.
Myoglobin– protein structure and function, haem group, oxidation and spin states of the metal centre before and after oxygen coordination
Haemoglobin – protein structure and function, comparison with Mb, the cooperative nature of oxygen binding in haemoglobin
Metallo-enzymes – details of the structure and function of Zn and Fe-containing systems
Metal ion binding in DNA. Discovery of metal-containing anti-tumour drugs. mode of action, side effects. Metal-based drugs

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Placement/Study AbroadEmployer-based learning420:5035:00Assessment - Preparation and completion of revision for end of semester examination (DL)
Placement/Study AbroadEmployer-based learning13:003:00Assessment - Preparation and completion of end of semester examination (DL)
Placement/Study AbroadEmployer-based learning421:0042:00Lecture - Recorded by ReCap and displayed on Blackboard (DL)
Placement/Study AbroadEmployer-based learning1120:00120:00Independent Study - Review ReCap lectures, background reading and practice past exam questions (DL)
Total200:00
Jointly Taught With
Code Title
CHY3306Advanced Inorganic Chemistry
CHY8832Contemporary Inorganic Chemistry
Teaching Rationale And Relationship

Lectures are delivered electronically and are used to impart knowledge. Student learning is supported by the provision of worksheets.

Assessment Methods

The format of resits will be determined by the Board of Examiners

Exams
Description Length Semester When Set Percentage Comment
Written Examination1802A100N/A
Exam Pairings
Module Code Module Title Semester Comment
CHY3306Advanced Inorganic Chemistry2N/A
CHY8832Contemporary Inorganic Chemistry2N/A
Assessment Rationale And Relationship

The examination will test the student's knowledge and understanding.

Students sit the examination on their return to Newcastle for one week during the Semester 2 examination period.

Reading Lists

Timetable