CMB2001 : Control of Eukaryotic Gene Expression

Semester 1 Credit Value: 10
ECTS Credits: 5.0


To develop knowledge and understanding of the mechanisms by which eukaryotes regulate gene expression through control of transcription, chromatin, mRNA stability and translation.

Outline Of Syllabus

This module introduces the basics of gene structure and transcription in eukaryotes; the role of, promoters, polymerases, and transcription factors and the regulation of their interaction with DNA. The structure of chromatin will be covered and the key role played by chromatin modifying enzymes in the regulation of transcription will be discussed. The mechanisms by which the activity of key human transcription factors is controlled in response to stress and infection will also be covered. The lectures provide an introduction to mRNA splicing and will also describe how regulation of mRNA stability can contribute to control of gene expression in eukaryotes. Because ultimately proteins are usually the final gene product, it is not surprising that translation, the last step in protein synthesis, is under precise cellular control. The lectures will therefore describe eukaryotic translation and the mechanisms by which it is regulated

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Guided Independent StudyAssessment preparation and completion16:006:00Data Interpretation Problem Solving Exercise
Scheduled Learning And Teaching ActivitiesLecture101:0010:00N/A
Guided Independent StudyDirected research and reading831:0083:00Private Study
Scheduled Learning And Teaching ActivitiesSmall group teaching11:001:00Feedback Session
Teaching Rationale And Relationship

Lectures are used to impart information in a concise manner, to highlight areas of importance (K1, K2, K4-K10) and to integrate with directed reading and self-directed study. The seminar is used for developing skills of data interpretation (K3, S1) and problem solving. Private study is used for self-directed learning including further reading (S2) and preparation for examinations. Students are expected to undertake 6hrs of independent study as preparation for the problem solving exercise.

Assessment Methods

The format of resits will be determined by the Board of Examiners

Description Length Semester When Set Percentage Comment
Written Examination751A90Multiple Choice Questions. 15-30 questions
Other Assessment
Description Semester When Set Percentage Comment
Prob solv exercises1M10MCQ (45 mins)
Assessment Rationale And Relationship

The in course data interpretation exercise tests knowledge and understanding and provides students with information about their progress. The data interpretation also tests the ability to apply knowledge and understanding to solve problems. The final examination also tests knowledge, understanding and the ability to interpret data.

Reading Lists