PSC2016 : Molecular Physiology and Pathophysiology
- Offered for Year: 2019/20
- Module Leader(s): Professor Jeffrey Pearson
- Lecturer: Dr Christopher Ward
- Owning School: Biomedical Sciences
- Teaching Location: Newcastle City Campus
|Semester 2 Credit Value:||15|
To provide an understanding at the molecular level of (1) aspects of the normal physiology and diseases of the aerodigestive tract and (2) connective tissue and proteoglycans in health and disease.
To provide a knowledge of how reflux of gastric duodenal juice, a normal physiological event can under certain conditions lead to damage of the aerodigestive tract.
This strand will also aim to give you an excellent understanding at a molecular level of structure function relationships involving proteoglycans e.g. connective tissue function and how this changes in disease. Also the role of proteoglycans in malaria and cancer cell migration.
Students will learn about: the relationships between acid and pepsin production by the stomach, reflux and diseases of the aerodigestive tract, such as GORD, LPR, sinusitis, rhinitis, asthma, vocal fold leukoplakia, laryngomalacia and OME. In addition they will see and discuss the experimental evidence for a link between the reflux of gastric juice and lung transplant rejection and the molecular mechanisms for the development of bronchiolitis obliterans syndrome. In addition the mechanisms of other aerodigestive diseases associated with reflux will be investigated. As a second molecular theme the students will learn about structure and functions of cartilage and the proteoglycans there contained and the changes that occur in osteoarthritis. They will also learn about the cellular functions of proteoglycans in other tissues. A mixture of formal lectures, seminars and a laboratory practical session, study group sessions, and student-led study groups will be used.
Outline Of Syllabus
Pepsin isoenzymes, bile acids and acid as inflammatory mediators, mucosal protection of different mucosal types.
Human diseases related to reflux.
Functions of proteoglycans and related diseases
|Scheduled Learning And Teaching Activities||Lecture||16||1:00||16:00||N/A|
|Guided Independent Study||Assessment preparation and completion||1||121:00||121:00||N/A|
|Guided Independent Study||Assessment preparation and completion||2||3:00||6:00||Study group exercises|
|Scheduled Learning And Teaching Activities||Practical||1||7:00||7:00||N/A|
Teaching Rationale And Relationship
Lectures convey the core scientific material. Practicals provide laboratory experience and practical demonstrations to support the core material, provide experience in computer-based presentation skills, and support the core material by placing basic scientific knowledge in a clinical context. Seminars provide opportunity for discussion and aid the development of critical skills and problem solving. Individual study topic encourages use of the scientific literature at a deeper level than that presented in lectures, promotes individual creative work, provides an opportunity to teach and learn through collective study, and promotes scientific discrimination of the literature.
The format of resits will be determined by the Board of Examiners
|Written Examination||90||2||A||70||The MCQ section is worth 1/3 (33.3%) the essay section is worth 2/3 (66.7%) Two questions to be answered from a choice of four.|
|Module Code||Module Title||Semester||Comment|
|Written exercise||2||M||8||Extended Essay|
|Written exercise||2||M||7||Analysis of Paper|
|Written exercise||2||M||7||Study Group Work|
Assessment Rationale And Relationship
The examination is appropriate way of testing core knowledge and understanding of the subject under time-constraint conditions. The practice essay promotes revision and provides an opportunity to consolidate knowledge and identify areas of weakness in learning and teaching. The practical report and abstract analysis exercise test critical skills, problem solving and data interpretation. The group study topic assesses a range of skills including teaching, data interpretation, computer-based presentational skills, written communication skills, and promotes deeper learning, and scientific discrimination of the literature, and encourages group discussion and constructive criticism of scientific work.