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Bio-printing heads

Bio-printing Heads

Quote: KT172817-W

The Challenge

  • Gels are attractive materials for the support and delivery of cells in cell printing experiments, as the aqueous environment provided by gels supports cell viability
  • Most commercial bioplotters in essence use a syringe to deposit cells in gels, which is slow and both the pressures and shear forces can harm the cells
  • There is a need for new methods of depositing cells in gels which are faster and have a higher yield of live cells

The Solution

Reactive jet impingement (ReJI): jetting of two gel precursors at one another such that they mix in mid-air and land on the substrate as gel.  This means that the deposited materials are still liquid when they are processed, so have a lower viscosity, and so lower pressures can be used and the cells remain viable.

  • This process is quick (~1000 drops per second), and easily scalable
  • Can provide a range of droplet volumes (nL to µL) for high resolution printing
  • Print gels with a cell concentration of 40 million cells/mL routinely achievable concentrations up to 90 million cells/mL have been demonstrated
  • Increased speed of maturation of micro-tissues when compared to syringe base technologies
  • Potential to vary cell type and cell density, gel type and concentration, and to add nano and microparticles
  • Has potential to allow for the rapid creation of complex gradient biological structures
  • Is a controllable “drop on demand” system with no waste
  • Currently developed as single and multiple (8 jets/4 materials produced) heads at Newcastle University

The Opportunity

  • Potential for use as part of a bioprinter to create cell/gel/biomaterial structures and high resolution multi material gel matrices which will support understanding of disease progression, drug testing, personalised medicine, and tissue engineering
  • Seeking collaborators interested in commercialising the print head for bioprinting applications, through collaborative research and/or licensing

Intellectual Property

A GB patent application has been filed for this technology.

Title: Printing apparatus and method
Application No: PCT/GB2018/051908
Filing Date: 06/07/2017

Contact

Dr Luke Judd Science, Agriculture & Engineering Enterprise Team, Research and Enterprise Services, Devonshire Building, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK

Bio-printing heads general idea and experimental set-up
Bio-printing heads: general idea and experimental set-up