Module Catalogue 2016/17

ACE2034 : Introduction to Immunology and Toxicology

  • Offered for Year: 2016/17
  • Module Leader(s): Prof. Ilias Kyriazakis
  • Owning School: Agriculture, Food & Rural Development
  • Teaching Location: Newcastle City Campus
Semesters
Semester 2 Credit Value: 10
ECTS Credits: 5.0
Pre Requisites
Pre Requisite Comment

N/A

Co Requisites
Co Requisite Comment

N/A

Aims

To introduce the students to the basic concepts and processes involved in immunology and toxicology in mammals. This knowledge of the fate of foreign compounds within the body, innate and adapted immune mechanisms, immune cells, and deregulation (allergies, auto-immune diseases, cancer) will support students further studies of human and animal health and its links to disease and nutrition in their further study. Students will also develop knowledge of the use of serological tests to assess infection status and risk assessment for potential toxins.

Outline Of Syllabus

The syllabus will cover the following topics involving lectures from University staff and external speakers.
- Fate of foreign compounds within the body
- Dose-response relationships
- Types of toxic responses especially to nutritional challenges and natural toxins (animal, plant, fungal and microbial)
- Natural defences
- Innate/Adaptive immunity
- Cellular and humoral immunity
- Production and use of antibodies
- Communication within the immune system
- Serological tests (ELISA, IFAT, Western blotting, Electron microscopy)
- Allergies
- Immunodeficiencies
- Auto-immune diseases
- Cancer
- Immunotoxicology
- Nutrition and the immune system

Learning Outcomes

Intended Knowledge Outcomes

After successful completion of this module the student will be able to:
- Describe and discriminate between the pathways governing response to foreign compounds in mammals
- Contrast the types of toxic responses occurring in mammals drawing examples from nutritional challenges and natural toxins (animal, plant, fungal and microbial)
- Describe and discriminate between the innate and adaptive mechanisms in place for infection control and their interplay
- Give clear examples of how cellular and humoral responses are generated during responses to infections and how the immune system can be overpowered by pathogens or through regulation problems
- Describe and discriminate the effects of toxic substances including natural toxins on the immune responses in mammals
- Critically discuss the issues associated with immune system deregulation
- Critically discuss the role of nutrition on the immune response

Intended Skill Outcomes

After successful completion of this module a student will be able to:
- Apply and interpret serological tests to measure immune response
- Identify the experiments needed to establish dose-response relationships to a range of toxins and their limitations
- Write technical reports clearly and support finding with reference to appropriate literature
- Handle and manipulate diagnostic test data and adopt analytical, quantitative approaches to problems.

Graduate Skills Framework

Graduate Skills Framework Applicable: Yes
  • Cognitive/Intellectual Skills
    • Critical Thinking : Assessed
    • Data Synthesis : Present
    • Active Learning : Present
    • Literacy : Assessed
    • Information Literacy
      • Source Materials : Present
      • Synthesise And Present Materials : Assessed
      • Use Of Computer Applications : Present
  • Self Management
    • Planning and Organisation
      • Goal Setting And Action Planning : Present
      • Decision Making : Present
    • Personal Enterprise
      • Innovation And Creativity : Present
      • Initiative : Present
      • Independence : Present
      • Problem Solving : Present
      • Adaptability : Present
  • Interaction
    • Communication
      • Oral : Assessed
      • Interpersonal : Present
      • Written Other : Assessed
    • Team Working
      • Collaboration : Present
      • Relationship Building : Present
  • Application
    • Occupational Awareness : Present

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Guided Independent StudyAssessment preparation and completion110:0010:00Preparation for ELISA report
Guided Independent StudyAssessment preparation and completion110:0010:00Preparation of essay
Guided Independent StudyAssessment preparation and completion110:3010:30Revision for and completion of Semester 2 examination
Scheduled Learning And Teaching ActivitiesLecture181:0018:00N/A
Scheduled Learning And Teaching ActivitiesSmall group teaching22:004:00Focused groups assessing practical problems
Scheduled Learning And Teaching ActivitiesWorkshops12:002:00Discussion of feedback from essays and of practical issues (toxicology)
Guided Independent StudyIndependent study125:3025:30Literature search and reading beyond the course material
Guided Independent StudyIndependent study120:0020:00Compilation of notes and follow up after lectures
Total100:00
Teaching Rationale And Relationship

Lectures and small group problem-based teaching allows the presentation of clear background information, extension of this materials by use of examples and identification of further reading to allow students to develop a substantial knowledge base on immunology and toxicology to meet all the Module's knowledge outcomes
The workshop (toxicology) allows for discussion of problems / issues which will require application of materials covered in class.
The small group teaching allows for the development of skills in practical immunological techniques and the interpretation of serological data, in particular the ability to handle and manipulate relevant diagnostic test data to improve numerical skills and adopt analytical, quantitative approaches to problems.

Reading Lists

Assessment Methods

The format of resits will be determined by the Board of Examiners

Exams
Description Length Semester When Set Percentage Comment
Written Examination902A60Essay type questions, answer 3 out of 5 questions. 2 questions for each topic area and one integrating question
Other Assessment
Description Semester When Set Percentage Comment
Essay2M20Essay, dose-response relationships to toxins, 1000 words
Practical/lab report2M20ELISA Report up to 3 pages
Assessment Rationale And Relationship

The examination allows a test of all the knowledge outcomes and assesses student's ability to integrate material as well as recall of key content of the module and relevant information from other sources.
The in-course assessment provides students with feedback on the development of their understanding and their ability to write technical reports clearly and support findings with reference to appropriate literature
The ELISA report specifically tests students ability to apply and interpret serological tests to measure immune response
The essay specifically focus on dose-response relationships to a range of toxins and their limitations.

Timetable

Past Exam Papers

General Notes

N/A

Note: The Module Catalogue now reflects module information relating to academic year 16/17. Please contact your School Office if you require module information for a previous academic year.

Disclaimer: The University will use all reasonable endeavours to deliver modules in accordance with the descriptions set out in this catalogue. Every effort has been made to ensure the accuracy of the information, however, the University reserves the right to introduce changes to the information given including the addition, withdrawal or restructuring of modules if it considers such action to be necessary.