|Semester 2 Credit Value:||10|
Stage 1, stage 2 semester 1. That is, BGM1001, CMB1000, CMB1001, PSC1001, BGM1003,
PED1002, CMB2002, CMB2003, CMB2004, CMB2005.
1. To provide a sound understanding of the molecular mechanisms underlying the replication, repair and recombination of DNA and to demonstrate the unique importance of the accuracy of these processes.
2. To provide a framework for understanding the different types of DNA damage, the mechanisms by which they are repaired and the diseases that result from defects in these repair processes.
This module provides an understanding of key DNA-dependent processes, such as the accurate replication of the genome and recombination, the mechanism which underpins genetic variation. Importantly, DNA is subject to constant damage and failure to accurately repair this damage results in mutations which lead to genetic instability and ultimately cancer. Therefore, a major component of the module focuses upon the mechanisms by which DNA damage is repaired and also considers the many devastating human diseases (e.g. developmental disorders, cancer predisposition and
premature ageing) that arise from defects in DNA repair processes. In course assessment (worth 20% of the module mark) is based upon a practical and a seminar session. The remaining assessment is by a written examination (mixture of EMI and essays).
This module provides an understanding of the following key DNA-dependent processes:
accurate replication of the genome and recombination;
mechanisms of genetic variation;
repair of DNA damage;
results of failure to correct DNA damage (e.g. mutation, genetic instability, cancer).
development of genetics diseases (e.g. developmental disorders, cancer predisposition and premature ageing)
1. Demonstrate an awareness of the unique importance of the accuracy of DNA replication and the need to correct any replication errors that may occur.
2. Demonstrate an understanding of the detailed molecular mechanisms of DNA replication.
3. Be able to describe the various types of damage that occur to DNA.
4. Understand and explain the detailed molecular mechanisms by which damaged DNA may be repaired.
5. Demonstrate and awareness of the association between defective human DNA repair processes and human disease.
6. Demonstrate an understanding of how UV-survival curves are determined.
Determination of UV survival curves
Determination of UV survival curves
General laboratory practice
General numeracy skills
|Graduate Skills Framework Applicable:||Yes|
|Scheduled Learning And Teaching Activities||Lecture||12||1:00||12:00||N/A|
|Scheduled Learning And Teaching Activities||Practical||1||6:00||6:00||N/A|
|Scheduled Learning And Teaching Activities||Drop-in/surgery||1||1:00||1:00||Seminar on practical results|
|Guided Independent Study||Independent study||1||81:00||81:00||N/A|
The lectures will be used to introduce the intended knowledge outcomes for the module. These will be reinforced by the material covered in the data analysis and practical sessions. The seminar will reinforce the lecture material and act as a feedback session for the practical and data-handing exercise. One seminar will be sufficient to cover this material (this is based on previous experience of running this section of the module as a strand in a number of other modules BGM2036, BGM2037 and BGM2038).
The format of resits will be determined by the Board of Examiners
|Written Examination||60||2||A||80||EMI (30%): 30 minutes Essay x 1 (70%): 45 minutes.|
|Practical/lab report||2||M||20||Students will gain experience in the accurate recording and also with determination of UV survival curves|
The assessments will test understanding of the material delivered, as well as providing training in key laboratory and
Original Handbook text:
Note: The Module Catalogue now reflects module information relating to academic year 14/15. Please contact your School Office if you require module information for a previous academic year.
Disclaimer: The University will use all reasonable endeavours to deliver modules in accordance with the descriptions set out in this catalogue. Every effort has been made to ensure the accuracy of the information, however, the University reserves the right to introduce changes to the information given including the addition, withdrawal or restructuring of modules if it considers such action to be necessary.