Module Catalogue 2014/15

BGM2056 : DNA Replication, recombination and Repair

  • Offered for Year: 2014/15
  • Module Leader(s):
  • Owning School:
Semesters
Semester 2 Credit Value: 10
ECTS Credits: 5.0
Pre Requisites
Pre Requisite Comment

Stage 1, stage 2 semester 1. That is, BGM1001, CMB1000, CMB1001, PSC1001, BGM1003,
PED1002, CMB2002, CMB2003, CMB2004, CMB2005.

Co Requisites
Co Requisite Comment

N/A

Aims

1. To provide a sound understanding of the molecular mechanisms underlying the replication, repair and recombination of DNA and to demonstrate the unique importance of the accuracy of these processes.

2. To provide a framework for understanding the different types of DNA damage, the mechanisms by which they are repaired and the diseases that result from defects in these repair processes.

Original Summary:
This module provides an understanding of key DNA-dependent processes, such as the accurate replication of the genome and recombination, the mechanism which underpins genetic variation. Importantly, DNA is subject to constant damage and failure to accurately repair this damage results in mutations which lead to genetic instability and ultimately cancer. Therefore, a major component of the module focuses upon the mechanisms by which DNA damage is repaired and also considers the many devastating human diseases (e.g. developmental disorders, cancer predisposition and
premature ageing) that arise from defects in DNA repair processes. In course assessment (worth 20% of the module mark) is based upon a practical and a seminar session. The remaining assessment is by a written examination (mixture of EMI and essays).

Outline Of Syllabus

This module provides an understanding of the following key DNA-dependent processes:

accurate replication of the genome and recombination;
mechanisms of genetic variation;
repair of DNA damage;
results of failure to correct DNA damage (e.g. mutation, genetic instability, cancer).
development of genetics diseases (e.g. developmental disorders, cancer predisposition and premature ageing)

Learning Outcomes

Intended Knowledge Outcomes

1. Demonstrate an awareness of the unique importance of the accuracy of DNA replication and the need to correct any replication errors that may occur.
2. Demonstrate an understanding of the detailed molecular mechanisms of DNA replication.
3. Be able to describe the various types of damage that occur to DNA.
4. Understand and explain the detailed molecular mechanisms by which damaged DNA may be repaired.
5. Demonstrate and awareness of the association between defective human DNA repair processes and human disease.
6. Demonstrate an understanding of how UV-survival curves are determined.

Intended Skill Outcomes

Subject specific
Determination of UV survival curves

Cognitive/Intellectual
Determination of UV survival curves

Key
General laboratory practice
General numeracy skills

Graduate Skills Framework

Graduate Skills Framework Applicable: Yes

    Teaching Methods

    Teaching Activities
    Category Activity Number Length Student Hours Comment
    Scheduled Learning And Teaching ActivitiesLecture121:0012:00N/A
    Scheduled Learning And Teaching ActivitiesPractical16:006:00N/A
    Scheduled Learning And Teaching ActivitiesDrop-in/surgery11:001:00Seminar on practical results
    Guided Independent StudyIndependent study181:0081:00N/A
    Total100:00
    Teaching Rationale And Relationship

    The lectures will be used to introduce the intended knowledge outcomes for the module. These will be reinforced by the material covered in the data analysis and practical sessions. The seminar will reinforce the lecture material and act as a feedback session for the practical and data-handing exercise. One seminar will be sufficient to cover this material (this is based on previous experience of running this section of the module as a strand in a number of other modules BGM2036, BGM2037 and BGM2038).

    Reading Lists

    Assessment Methods

    The format of resits will be determined by the Board of Examiners

    Exams
    Description Length Semester When Set Percentage Comment
    Written Examination602A80EMI (30%): 30 minutes Essay x 1 (70%): 45 minutes.
    Other Assessment
    Description Semester When Set Percentage Comment
    Practical/lab report2M20Students will gain experience in the accurate recording and also with determination of UV survival curves
    Assessment Rationale And Relationship

    The assessments will test understanding of the material delivered, as well as providing training in key laboratory and
    numeracy skills.

    Timetable

    Past Exam Papers

    General Notes

    Original Handbook text:

    Note: The Module Catalogue now reflects module information relating to academic year 14/15. Please contact your School Office if you require module information for a previous academic year.

    Disclaimer: The University will use all reasonable endeavours to deliver modules in accordance with the descriptions set out in this catalogue. Every effort has been made to ensure the accuracy of the information, however, the University reserves the right to introduce changes to the information given including the addition, withdrawal or restructuring of modules if it considers such action to be necessary.