Module Catalogue 2014/15

BGM2056 : DNA Replication, recombination and Repair

  • Offered for Year: 2014/15
  • Module Leader(s): Dr Simon Whitehall
  • Owning School: Biomedical Sciences
Semesters
Semester 2 Credit Value: 10
ECTS Credits: 5.0
Pre Requisites
Pre Requisite Comment

N/A

Co Requisites
Co Requisite Comment

N/A

Aims

1. To provide a sound understanding of the molecular mechanisms underlying the replication, repair and recombination of DNA and to demonstrate the unique importance of the accuracy of these processes.

2. To provide a framework for understanding the different types of DNA damage, the mechanisms by which they are repaired and the diseases that result from defects in these repair processes.

Outline Of Syllabus

This module provides an understanding of the following key DNA-dependent processes:

accurate replication of the genome and recombination;
mechanisms of genetic variation;
repair of DNA damage;
results of failure to correct DNA damage (e.g. mutation, genetic instability, cancer).
development of genetics diseases (e.g. developmental disorders, cancer predisposition and premature ageing)

Learning Outcomes

Intended Knowledge Outcomes

1. Demonstrate an awareness of the unique importance of the accuracy of DNA replication and the need to correct any replication errors that may occur.
2. Demonstrate an understanding of the detailed molecular mechanisms of DNA replication.
3. Be able to describe the various types of damage that occur to DNA.
4. Understand and explain the detailed molecular mechanisms by which damaged DNA may be repaired.
5. Demonstrate and awareness of the association between defective human DNA repair processes and human disease.
6. Demonstrate an understanding of how UV-survival curves are determined.

Intended Skill Outcomes

Subject specific
Determination of UV survival curves

Cognitive/Intellectual
Determination of UV survival curves

Key
General laboratory practice
General numeracy skills

Graduate Skills Framework

Graduate Skills Framework Applicable: Yes
  • Cognitive/Intellectual Skills
    • Critical Thinking : Assessed
    • Data Synthesis : Assessed
    • Active Learning : Present
    • Numeracy : Assessed
    • Literacy : Assessed
  • Interaction
    • Communication
      • Written Other : Assessed
    • Team Working
      • Collaboration : Present

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Scheduled Learning And Teaching ActivitiesLecture121:0012:00
Scheduled Learning And Teaching ActivitiesPractical16:006:00The practical runs over 2 days
Scheduled Learning And Teaching ActivitiesSmall group teaching11:001:00Seminar - Discussion on practical results
Guided Independent StudyIndependent study181:0081:00
Total100:00
Teaching Rationale And Relationship

The lectures will be used to introduce the intended knowledge outcomes for the module. These will be reinforced by the material covered in the data analysis and practical sessions. The seminar will reinforce the lecture material and acts as a feedback session for the practical and data-handing exercise.

Reading Lists

Assessment Methods

The format of resits will be determined by the Board of Examiners

Exams
Description Length Semester When Set Percentage Comment
Written Examination752A80EMI (30%): 30 minutes Essay x 1 (70%): 45 minutes.
Other Assessment
Description Semester When Set Percentage Comment
Practical/lab report2M20Students will gain experience in the accurate recording and also with determination of UV survival curves
Assessment Rationale And Relationship

The assessments will test understanding of the material delivered, as well as providing training in key laboratory and
numeracy skills.

Timetable

Past Exam Papers

General Notes

Original Handbook text:

Note: The Module Catalogue now reflects module information relating to academic year 14/15. Please contact your School Office if you require module information for a previous academic year.

Disclaimer: The University will use all reasonable endeavours to deliver modules in accordance with the descriptions set out in this catalogue. Every effort has been made to ensure the accuracy of the information, however, the University reserves the right to introduce changes to the information given including the addition, withdrawal or restructuring of modules if it considers such action to be necessary.