Module Catalogue 2017/18

//Change - 3005097

BGM2060 : Proteins and Enzymes

  • Offered for Year: 2017/18
  • Module Leader(s): Dr David Bolam
  • Lecturer: Prof. Jeremy Lakey, Dr Kevin Waldron, Dr Elizabeth Veal
  • Practical Supervisor: Prof. Christopher Dennison, Prof. Rick Lewis
  • Owning School: Biomedical Sciences
  • Teaching Location: Newcastle City Campus
Semesters
Semester 2 Credit Value: 20
ECTS Credits: 10.0
Pre Requisites
Pre Requisite Comment

Stage 1, Stage 2 semester 2. That is, BGM1001, CMB1000, CMB1001, PSC1001, BGM1003,
PED1002, CMB2002, CMB2003, CMB2004, CMB2005.

Co Requisites
Co Requisite Comment

None

Aims

The aim of the module is to provide students with a detailed understanding of protein structure, synthesis, function and use, with particular focus on enzymes.

Outline Of Syllabus

•       properties of proteins and enzymes, macromolecules essential to all life.
•       protein secondary structure, super secondary structure and tertiary folds and introduce protein folding
•       why proteins are the shape they are
•       specific interactions between enzymes and substrates are determined by protein structure and how preferential binding of the transition state by enzymes leads to catalysis
•       kinetic parameters that describe enzyme catalysis, inhibition and allosteric regulation
•       mechanisms of action of several major enzyme classes to illustrate key catalytic strategies.

Learning Outcomes

Intended Knowledge Outcomes

On completion of the module students will be able to:

1. Discuss advanced aspects of protein biochemistry such as protein structure and folding.
2. Explain the quantitative determination and significance of enzyme steady-state kinetic parameters.
3. Discuss the structural basis of enzyme catalysis and substrate specificity, and the contribution of kinetic and physical experiments to an understanding of these properties.
4. Describe the different mechanisms by which enzymes can be inhibited by small molecules and the importance of enzyme inhibitors as drugs and toxins.
5. Describe how allosteric properties are related to protein structure.
6. Illustrate and compare the enzymology of selected biological catalysts.
7. Solve quantitative and conceptual problems in each of these topics.

Intended Skill Outcomes

On completion of the module students will be able to:
1. Generate, analyse and interpret experimental data
2. Solve quantitative and conceptual problems in proteomics and enzymology.
3. Generate reports.

Graduate Skills Framework

Graduate Skills Framework Applicable: Yes
  • Cognitive/Intellectual Skills
    • Critical Thinking : Present
    • Active Learning : Present
    • Numeracy : Present
    • Literacy : Present
    • Information Literacy
      • Source Materials : Present
      • Use Of Computer Applications : Present
  • Self Management
    • Self Awareness And Reflection : Present
    • Planning and Organisation
      • Goal Setting And Action Planning : Present
      • Decision Making : Present
    • Personal Enterprise
      • Innovation And Creativity : Assessed
      • Initiative : Present
      • Independence : Present
      • Problem Solving : Assessed
  • Interaction
    • Communication
      • Interpersonal : Present
      • Written Other : Assessed
    • Team Working
      • Collaboration : Present
      • Relationship Building : Present
      • Leadership : Present
      • Negotiation : Present

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Scheduled Learning And Teaching ActivitiesLecture201:0020:00Lectures
Scheduled Learning And Teaching ActivitiesPractical26:0012:00N/A
Guided Independent StudyIndependent study1168:00168:00N/A
Total200:00
Teaching Rationale And Relationship

The lectures will cover the key points of the module and will be reinforced by the practicals. The practicals form the core of this module as they will give the students ‘hands-on’ experience of the key methods discussed in the lectures, and provide training in data acquisition, interpretation and critical analysis.

Reading Lists

Assessment Methods

The format of resits will be determined by the Board of Examiners

Exams
Description Length Semester When Set Percentage Comment
Written Examination902A80Two essays to be answered from a choice of 4. Each essay contributes 50% of the mark
Other Assessment
Description Semester When Set Percentage Comment
Practical/lab report2M10One thousand to one thousand five hundred words.
Practical/lab report2M10One thousand to one thousand five hundred words.
Assessment Rationale And Relationship

Exams test all knowledge across the module.
Practicals assess students understanding of key points in the lectures, ability to report and analyse results, and tests their team work skills (students will work in groups of 2 or more) and general laboratory skills.
The practical write up tests data analysis, critical thinking and report-writing skills and will be scheduled sufficiently far apart to allow feedback from report 1 to be used formatively to improve submission of report 2.

Timetable

Past Exam Papers

General Notes

Original Handbook text:

Disclaimer: The information contained within the Module Catalogue relates to the 2017/18 academic year. In accordance with University Terms and Conditions, the University makes all reasonable efforts to deliver the modules as described. Modules may be amended on an annual basis to take account of changing staff expertise, developments in the discipline, the requirements of external bodies and partners, and student feedback. Module information for the 2017/18 entry will be published here in early-April 2017. Queries about information in the Module Catalogue should in the first instance be addressed to your School Office.