BGM3056 : Evolution and Genomics
BGM3056 : Evolution and Genomics
- Offered for Year: 2024/25
- Module Leader(s): Professor Robert Hirt
- Lecturer: Dr Sergey Melnikov
- Owning School: Biomedical, Nutritional and Sports Scien
- Teaching Location: Newcastle City Campus
Semesters
Your programme is made up of credits, the total differs on programme to programme.
Semester 1 Credit Value: | 10 |
ECTS Credits: | 5.0 |
European Credit Transfer System | |
Pre-requisite
Modules you must have done previously to study this module
Pre Requisite Comment
N/A
Co-Requisite
Modules you need to take at the same time
Co Requisite Comment
N/A
Aims
i. To provide a general understanding of how ideas from evolutionary biology inform, and are informed by, genomic science.
ii. To provide some deeper insights into the origin and evolution of the eukaryotic genome and the roles of gene and genome duplication, vertical inheritance, lateral gene transfer and endosymbiosis in its formation and diversification.
iii. To highlight how studies of parasite genomes have provided general insights into how genomes evolve as well as clues to pathogenic mechanisms and potential therapies.
iv. To provide knowledge and understanding of the tools used to analyse genomes.
Outline Of Syllabus
Lecture and directed study material:
• Evolutionary biology describes the history of life and explains why organisms and genomes are the way they are.
• Definitions and concepts, homology, descent with modification and natural selection, evidence for evolution, the new synthesis, neutral theory.
• The first whole genome sequences, the technology and discoveries, large-scale patterns and processes of genome evolution. How do prokaryotic and eukaryotic genomes differ?
• Making sense of the data - how are genomes analysed, bioinformatics: computer tools for recognising genes and structure – function prediction. RNA-Seq, proteomics and other ‘omic technologies.
• Phylogenetics, as a tool for understanding the evolution of genes, genomes and species. The origins of eukaryotic genomes, lateral gene transfer and vertical inheritance, endosymbiosis and eukaryotic evolution, is there a tree of life and what does it mean?
• Comparative analyses and insights from parasite genomes, obligate intracellular, and extracellular parasites (Microsporidia and Trichomonas case studies and viruses).
• The human microbiota in health and disease, new insights from metagenomics.
Learning Outcomes
Intended Knowledge Outcomes
By the end of the module students will have acquired:
1. A knowledge and understanding of the current value and potential of genomic science in biology
2. A knowledge and understanding of how ideas from evolutionary biology inform, and are informed by, genomic science
3. A knowledge and understanding of some important discoveries from genomic analyses
4. A knowledge and understanding of the tools used for analysing genomes
Intended Skill Outcomes
By the end of the module students will be able to:
1. Critically interpret and synthesise complex information relating to evolution and genomic science
2. Have further developed the capacity to critically read the scientific literature
3. Have further developed written communication skills
Teaching Methods
Teaching Activities
Category | Activity | Number | Length | Student Hours | Comment |
---|---|---|---|---|---|
Scheduled Learning And Teaching Activities | Lecture | 13 | 1:00 | 13:00 | In person |
Scheduled Learning And Teaching Activities | Small group teaching | 1 | 1:00 | 1:00 | In person seminar: Introduction to ICA and Q&A sessions |
Guided Independent Study | Independent study | 1 | 86:00 | 86:00 | Writing up lecture notes, revision and general reading. |
Total | 100:00 |
Jointly Taught With
Code | Title |
---|---|
BGM3058 | Integrated Genetics |
BGM3061 | Genetic variation in common disease |
BGM3062 | Genetics of Development and its Disorders |
Teaching Rationale And Relationship
Lectures impart knowledge of key issues in genomic science. Genomics is a rapidly evolving field - directed reading from discovery and review journals will be used to keep abreast of key developments and to encourage critical faculties.
Private study is necessary for students to absorb information presented in lectures and for self-assessment, to deepen their knowledge and understanding through directed reading, to become familiar with the web and its resources for genome analysis.
The scheduled seminar, interactive with the students, provides an opportunity for Q&A sessions to help revise the taught material, and to introduce the in-course assessment - Invigilated Timed Essay (1 hour)
Reading Lists
Assessment Methods
The format of resits will be determined by the Board of Examiners
Exams
Description | Length | Semester | When Set | Percentage | Comment |
---|---|---|---|---|---|
Written Examination | 60 | 2 | A | 70 | Invigilated exam, 1 essay question from choice of 2 |
Other Assessment
Description | Semester | When Set | Percentage | Comment |
---|---|---|---|---|
Essay | 1 | M | 30 | Invigilated Timed Essay(60 min) |
Assessment Rationale And Relationship
The examination provides evidence of knowledge and understanding of the topics.
The timed essay will provide evidence of critical analysis of published work and clarity of communication of scientific ideas.
Timetable
- Timetable Website: www.ncl.ac.uk/timetable/
- BGM3056's Timetable
Past Exam Papers
- Exam Papers Online : www.ncl.ac.uk/exam.papers/
- BGM3056's past Exam Papers
General Notes
Original Handbook text:
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Disclaimer
The information contained within the Module Catalogue relates to the 2024 academic year.
In accordance with University Terms and Conditions, the University makes all reasonable efforts to deliver the modules as described.
Modules may be amended on an annual basis to take account of changing staff expertise, developments in the discipline, the requirements of external bodies and partners, and student feedback. Module information for the 2025/26 entry will be published here in early-April 2025. Queries about information in the Module Catalogue should in the first instance be addressed to your School Office.