|Semester 2 Credit Value:||20|
• To develop an appreciation of the part played by the immune system in a range of human diseases
•To build upon the students’ knowledge of basic virology and develop an understanding of the biology of pathogenic viruses
Clinical Immunology Strand:
The module considers the role of the immune system in human disease. The first part of the module considers immunitiy in the context of infectious disease with particular reference to inflammation and immunodeficiency. The second part of the module considers how immune responses can cause disease with reference to allergic disease, autoimmunity, cancers of the immune system and transplantation. Finally the module describes the diagnostic techniques currently used in clinical immunology, immunosuppressive drugs and the potential of immunomodulation and immunotherapy in the treatment of a number of conditions.
Strand B (Viral Pathogens) considers the ways in which viruses cause disease. It examines the mechanisms by which viruses enter host cells, replicate within them and are finally released and transmitted from man to man and from animals to man. The host response to viral infection is described and the outcomes, including full recovery, acute infection, chronic infection, latent infection and death are considered. Specific examples, including measles virus, hepatitis B virus, herpes viruses and Ebola virus are described. The role of viruses in development of some cancers is discussed, examining the role of human papilloma virus in cervical cancer in particular. Finally retroviruses are discussed, including HIV and retroviruses used in gene therapy.
Strand A Clinical Immunology Learning Outcomes:
By the end of this section students should be able to:
-Explain what is meant by primary and secondary immunodeficiency; discuss the causes of immunodeficiency and the consequences of different types of immunodeficiency
-Explain the molecular and cellular events underlying acute and chronic inflammation. Appreciate the clinical significance of inflammation and give specific examples of inflammatory disease
-Explain what is meant by hypersensitivity and its significance; describe the mechanisms underlying each of the four main types of hypersensitivity reaction and give specific examples of each
-Explain what is meant by an allergic reaction; appreciate the clinical significance of allergy and give examples of allergic diseases
-Discuss what constitutes an autoimmune disease; explain the distinction between organ-specific and non-organ-specific autoimmune diseases and give examples of each; discuss how autoimmune reactions may account for the pathogenesis of organ-specific and non-organ specific diseases; discuss the factors that may contribute to the development of autoimmune disease
-Explain what is meant by ‘immune surveillance”; discuss the prospects for harnessing immune responses against tumours in cancer therapy
-Define the terms autograft, allograft and xenograft; describe the events which may lead to allograft rejection, and the steps that can be taken to minimise the chances of this occurring
-Discuss the role of the immune system in pregnancy.
-Discuss the features and roles of the mucosal immune systems that deal with many of the infectious we experience.
Strand B: Viral Pathogens Learning Outcomes:
By the end of this section students should be able to:
• Explain the following features of viral pathogenesis:
How viruses infect human tissues and the host response to viral infection
The range of outcomes of viral infection
Acute, chronic and latent viral infections
Transmission of viruses from animals to man (zoonoses)
How oncogenic viruses are associated with tumour development
Mechanisms of infection by retroviruses and associated diseases
• Describe specific viral pathogens which can be used to illustrate the features listed above.
• Describe examples of drugs used to treat viral infection and explain their mechanism of action
By the end of this module students will be able to
Demonstrate oral communication skills.
Interpret and synthesize complex information relating to clinical immunology and virology.
Source material from appropriate databases.
Demonstrate team working skills.
|Graduate Skills Framework Applicable:||Yes|
|Scheduled Learning And Teaching Activities||Lecture||2||1:00||2:00||Seminar - full module cohort in attendance|
|Scheduled Learning And Teaching Activities||Lecture||28||1:00||28:00||N/A|
|Scheduled Learning And Teaching Activities||Small group teaching||1||2:00||2:00||Poster Presentation|
|Guided Independent Study||Independent study||1||168:00||168:00||N/A|
Lectures will provide students with key information and guidance for additional reading.
Seminars develop interpersonal communication and increase understanding of lecture material by application of knowledge and discussion with peers and teachers. Private study will allow students to extend and reinforce their knowledge and understanding through reading of text books, journal articles and use of other recommended resources (eg online).
The format of resits will be determined by the Board of Examiners
|Written Examination||120||2||A||80||Unseen – 50% EMI/Short Answer and 50% essay.|
|Module Code||Module Title||Semester||Comment|
|MIC2027||Parasitic and Viral Diseases||2||N/A|
|Prof skill assessmnt||2||M||10||Poster Presentation - as a team present a poster of a viral disease|
|Case study||2||M||10||Interpret clinical information for a case study (1000 words)|
The examination assesses knowledge and understanding of the topics.
The poster presentation assesses information literacy, computer literacy, ability to interpret scientific papers, planning and organisation skills, group working skills and oral presentation skills. The case study assesses ability to interpret scientific data, problem solving skills, interpersonal communication skills and group working skills.
Original Handbook text:
Note: The Module Catalogue now reflects module information relating to academic year 14/15. Please contact your School Office if you require module information for a previous academic year.
Disclaimer: The University will use all reasonable endeavours to deliver modules in accordance with the descriptions set out in this catalogue. Every effort has been made to ensure the accuracy of the information, however, the University reserves the right to introduce changes to the information given including the addition, withdrawal or restructuring of modules if it considers such action to be necessary.