Module Catalogue 2016/17

CMB2004 : Cell and Molecular Biology of the Immune System

  • Offered for Year: 2016/17
  • Module Leader(s): Dr Andrew Knight
  • Other Staff: Dr Amy Anderson, Dr Vanessa Armstrong, Dr Nicola Maney
  • Owning School: Biomedical Sciences
  • Teaching Location: Newcastle City Campus
Semester 1 Credit Value: 10
ECTS Credits: 5.0
Pre Requisites
Code Title
CMB1003Microbiology and Immunology
Pre Requisite Comment


Co Requisites
Co Requisite Comment



- To develop knowledge and understanding of the molecular and cell biology underlying a specific immune response, and to describe how such responses can protect against infection.

Outline Of Syllabus

Antibodies, T cell receptors and MHC molecules
Genetics of antigen recognition systems
Lymphocyte development
Lymphocyte activation
Regulation of immune responses
Antibody Technology
Immunity against infection/immunization

Learning Outcomes

Intended Knowledge Outcomes

•Describe the molecular structure of antibodies, T cell receptors and MHC class I and class II molecules

•Describe how antibody technology can be utilised

•Explain the part played by each of these molecules in antigen-recognition by T and B lymphocytes

•Describe the genetics of each of these types of molecule

•Discuss how the diverse repertoire of antibodies and T cell receptors is generated

•Explain how T cells are activated by antigens, and the consequences of this activation

•Explain what is meant by T-dependent and T-independent antigens and describe how these activate B cells

•Describe the stages of lymphocyte maturation from pluripotent haematopoietic stem cells

•Explain the need for immunological tolerance to self antigens and discuss how this is achieved

•Discuss how immune responses can be regulated, and the significance of qualitative regulation of immune responses

•Describe how specific immune responses can lead to the activation of effector mechanisms against infections with bacteria, viruses and eukaryotic parasites and how immunization aims to achieve protective responses

Intended Skill Outcomes

To be able to interpret scientific information, in this instance immunological data relating to case studies

Graduate Skills Framework

Graduate Skills Framework Applicable: Yes
  • Cognitive/Intellectual Skills
    • Critical Thinking : Assessed
    • Active Learning : Present
    • Numeracy : Present
    • Information Literacy
      • Source Materials : Present
      • Synthesise And Present Materials : Present
  • Interaction
    • Communication
      • Oral : Present
      • Interpersonal : Present
    • Team Working
      • Collaboration : Present

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Scheduled Learning And Teaching ActivitiesLecture121:0012:00N/A
Scheduled Learning And Teaching ActivitiesSmall group teaching11:301:30Seminars
Guided Independent StudyIndependent study186:3086:30N/A
Teaching Rationale And Relationship

Lectures are used to impart information in a concise manner, to highlight areas of importance and to interrelate with directed reading and self-directed study. The seminar is used for developing higher level skills of data interpretation and problem-solving as well as information retrieval. Private study is used for self-directed learning including further reading and preparation for examinations.

Reading Lists

Assessment Methods

The format of resits will be determined by the Board of Examiners

Description Length Semester When Set Percentage Comment
Written Examination601A100EMI
Assessment Rationale And Relationship

Knowledge and understanding is assessed through a summative examination.

FMS Schools offering Semester One modules available as ‘Study Abroad’ will, where required, provide an alternative assessment time for examinations that take place after the Christmas vacation. Coursework with submissions dates after the Christmas vacation will either be submitted at an earlier date or at the same time remotely.

The form of assessment will not vary from the original.


Past Exam Papers

General Notes


Disclaimer: The information contained within the Module Catalogue relates to the 2016/17 academic year. In accordance with University Terms and Conditions, the University makes all reasonable efforts to deliver the modules as described. Modules may be amended on an annual basis to take account of changing staff expertise, developments in the discipline, the requirements of external bodies and partners, and student feedback. Module information for the 2017/18 entry will be published here in early-April 2017. Queries about information in the Module Catalogue should in the first instance be addressed to your School Office.