Module Catalogue 2024/25

Pre Requisite Comment

NES2403 - Inorganic Chemistry

Co Requisite Comment

N/A

Aims

To introduce the fundamental principles and reactions of organometallic chemistry; to introduce concepts of homogeneous catalysis; to demonstrate the diverse chemistry of the s- and p-elements; to introduce inorganic aspects of biological systems and metals in biomedicine; to introduce the fundamentals, diversity and applications of chemistry in the solid state

Outline Of Syllabus

The module will be presented in four courses – Organometallic Chemistry; Bio-inorganic Chemistry; Contemporary Main Group Chemistry; Solid-state Chemistry



Organometallic Chemistry

*Topics selected from the following

*Background and introduction

*The 18-Electron rule

*Important ligand types; carbonyl (bonding and binary carbonyls)

*Pi-ligands, hydrides, phosphines

*The synthesis of organometallic compounds

*Organometallic reaction mechanisms 1. Reaction at the metal: ligand substitution, oxidative addition and

reductive elimination

*Organometallic reaction mechanisms 2: Reactions involving the ligand: migratory insertion, reductive

elimination and nucleophilic additions and abstractions

*Transition metal carbene complexes: synthesis, structure and reactivity

*Homogeneous catalysis: an introduction



Bioinorganic Chemistry

*An introduction to bioinorganic chemistry; the essential metals, metal ion overload-deficiency and treatments.

*An introduction to metalloproteins. Protein structure, metal ion binding groups, protein function and role of metal ions.

*Further topics selected from the following

*Myoglobin– protein structure and function, haem group, oxidation and spin states of the metal centre before and after oxygen coordination

*Haemoglobin – protein structure and function, comparison with Mb,

*Metallo-enzymes – details of the structure and function of Zn and Fe-containing systems

*Metal ion binding in DNA. Discovery of metal-containing anti-tumour drugs. mode of action, side effects. Metal-based drugs



Comparative Main Group Chemistry

Topics selected from the following:

*General principles. Complexes of the s-elements: macrocycles and the macrocyclic effect, alkalides and electrides

*Organometallics of the electropositive metals: an introduction to electron-deficient compounds

*More electron-deficient compounds: boranes and carboranes, Zintl ions

*Low oxidation states of the p-block elements (groups 13 and 14)

*E=E bonds (groups 14 and 15); synthesis and reactions. Phosphorus (V) ylides and related compounds

*E=E’ bonds – stability, synthesis and reactions



Sold-state Chemistry

Topics selected from the following: 

 *Introduction to solid-state chemistry – background, applications, importance and diversity of materials and structures types of solid state, i.e., 0D to 3D, including crystals and molecular solids. 

*Structures of solids – crystal structure and chemistry, packing, unit cells and important structures. 

*Bonding and electronic structure in solids – types of bonding in solids, band theory, metals/semiconductors/insulators.   

*Electrical properties – metallic conductivity, superconductivity + semiconductors. 

*Ionic diffusion and conductivity – how ions move in solids, models and types of diffusion, role of ionic conductivity.   

*Defects, doping and non-stoichiometry in crystals – points defects and why they form, extended defects, role of doping and nonstoichiometry.

Intended Knowledge Outcomes

At the end of this module, students will:

• understand organometallic synthesis and reaction mechanism

• know about homogenous catalysis using organometallic compounds

• know about the organometallics of groups 1, 2 and 13

• know about the low oxidation state and multiply-bonded compounds of the p-block elements

• understand the chemistry of boranes and related cluster compounds

• understand of basic principles of bioinorganic chemistry

• know about the biological function of transition metal ions

• know about the biological periodic table

• know about a range of metalloproteins

• understand details of the interaction of metal ions and complexes with nucleic acid

• know about metal complexes as drugs

• know understand the mechanism of action of platinum-based anti-cancer drugs

understand and appreciate the background, diversity, applications and importance of materials in the solid state

understand the various structures and types of solid compounds

understand the role of defects and doping in crystalline materials and how these influence properties

know about the various types of bonding and electronic structures in solid compounds

Intended Skill Outcomes

Cognitive or intellectual skills, able to:
• visualize three-dimensional inorganic molecules
• solve problems concerning inorganic bonding, synthesis and mechanism (more advanced than Stage 2)

Key skills, able to:
• plan and organise studies
• undertake self-directed study

Teaching Rationale And Relationship

Lecture materials and revision sessions are delivered in-person and electronically and are used to impart knowledge/understanding.

Assessment Rationale And Relationship

A formative exam will assess the level of knowledge and understanding from topics studied in semester 1. This will allow the module team to review and feedback on any topic which may have been problematic.

The summative written examination will assess the level of knowledge and understanding of the content of the module. The examination will present students with questions from a selection of topics learnt throughout semester 1 and 2 module content.

General Notes

N/A