PED3005 : Advanced Pharmacogenetics
PED3005 : Advanced Pharmacogenetics
- Offered for Year: 2024/25
- Module Leader(s): Professor James Allan
- Lecturer: Dr Alison Howard, Dr Simon Wilkinson, Dr Simon Cockell, Dr Ruben Thanacoody
- Owning School: Biomedical, Nutritional and Sports Scien
- Teaching Location: Newcastle City Campus
Semesters
Your programme is made up of credits, the total differs on programme to programme.
| Semester 1 Credit Value: | 10 |
| ECTS Credits: | 5.0 |
| European Credit Transfer System | |
Pre-requisite
Modules you must have done previously to study this module
| Code | Title |
|---|---|
| PED2001 | Drug Disposition and Pharmacokinetics |
Pre Requisite Comment
N/A
Co-Requisite
Modules you need to take at the same time
Co Requisite Comment
N/A
Aims
To provide information on how genetic factors affect the metabolism of foreign compounds and drug receptor
interactions.
To develop knowledge on the importance of inter-individual variability in drug metabolism in the drug
development process and in therapeutics.
To discuss current views on the relationship between pharmacogenetic polymorphisms and disease
susceptibility and potential approaches to drug design using pharmacogenomics.
To provide an introduction to molecular epidemiology.
To develop knowledge of the molecular basis of polymorphisms in drug metabolizing enzymes,
including the cytochromes P450, the glutathione S-transferases and N-acetyltransferases as well as
polymorphisms in drug receptors and other drug targets.
Outline Of Syllabus
See above.
Learning Outcomes
Intended Knowledge Outcomes
At the end of the module students should be able to:
1. A knowledge and understanding of the molecular basis of polymorphisms in drug metabolizing
enzymes, including the cytochromes P450, the glutathione S-transferases and N-acetyltransferases
2. A knowledge and understanding of the importance of inter-individual variability in drug metabolism
in the drug development process and in therapeutics
3. A knowledge and understanding of polymorphisms in drug receptors and other drug targets
4. An understanding of the relationship between genetic polymorphisms and disease susceptibility
Intended Skill Outcomes
At the end of this module students should be able to:
• Describe the importance of pharmacogenetics and pharmacogenomics to pharmacology
• Understand the main techniques used in pharmacogenetics
• Give examples of pharmacogenetic polymorphisms important to drug metabolism and discuss their
molecular basis
• Give examples of pharmacogenetic polymorphisms important to drug action and discuss their
molecular basis
• Understand the relevance of pharmacogenetics to adverse drug reactions and drug response
Teaching Methods
Teaching Activities
| Category | Activity | Number | Length | Student Hours | Comment |
|---|---|---|---|---|---|
| Scheduled Learning And Teaching Activities | Lecture | 14 | 1:00 | 14:00 | In person |
| Guided Independent Study | Assessment preparation and completion | 1 | 1:00 | 1:00 | In person - EMI assessment |
| Guided Independent Study | Independent study | 1 | 85:00 | 85:00 | Writing up lecture notes, revision and general reading. |
| Total | 100:00 |
Teaching Rationale And Relationship
Lectures will define the scope of the course and communicate knowledge as a basis for further study. This is an advanced course involving reading of research as well as advanced textbooks.
Reading Lists
Assessment Methods
The format of resits will be determined by the Board of Examiners
Exams
| Description | Length | Semester | When Set | Percentage | Comment |
|---|---|---|---|---|---|
| Written Examination | 90 | 2 | A | 80 | Invigilated exam. Answer 2 from 4 questions. |
Other Assessment
| Description | Semester | When Set | Percentage | Comment |
|---|---|---|---|---|
| Prob solv exercises | 1 | M | 20 | Invigilated paper based EMI (1 hour duration) 25 Questions. |
Assessment Rationale And Relationship
The EMI assesses student knowledge and understanding of course material.
FMS Schools offering Semester One modules available as ‘Study Abroad’ will, where required, provide an alternative assessment time for examinations that take place after the Christmas vacation. Coursework with submissions dates after the Christmas vacation will either be submitted at an earlier date or at the same time remotely.
Timetable
- Timetable Website: www.ncl.ac.uk/timetable/
- PED3005's Timetable
Past Exam Papers
- Exam Papers Online : www.ncl.ac.uk/exam.papers/
- PED3005's past Exam Papers
General Notes
Original Handbook text:
Welcome to Newcastle University Module Catalogue
This is where you will be able to find all key information about modules on your programme of study. It will help you make an informed decision on the options available to you within your programme.
You may have some queries about the modules available to you. Your school office will be able to signpost you to someone who will support you with any queries.
Disclaimer
The information contained within the Module Catalogue relates to the 2024 academic year.
In accordance with University Terms and Conditions, the University makes all reasonable efforts to deliver the modules as described.
Modules may be amended on an annual basis to take account of changing staff expertise, developments in the discipline, the requirements of external bodies and partners, and student feedback. Module information for the 2025/26 entry will be published here in early-April 2025. Queries about information in the Module Catalogue should in the first instance be addressed to your School Office.