PSC2016 : Molecular Physiology and Pathophysiology
PSC2016 : Molecular Physiology and Pathophysiology
- Offered for Year: 2024/25
- Module Leader(s): Professor Jeffrey Pearson
- Lecturer: Professor Christopher Ward
- Owning School: Biomedical, Nutritional and Sports Scien
- Teaching Location: Newcastle City Campus
Semesters
Your programme is made up of credits, the total differs on programme to programme.
| Semester 2 Credit Value: | 15 |
| ECTS Credits: | 8.0 |
| European Credit Transfer System | |
Pre-requisite
Modules you must have done previously to study this module
Pre Requisite Comment
PSC1002
Co-Requisite
Modules you need to take at the same time
Co Requisite Comment
None
Aims
To provide an understanding at the molecular level of (1) aspects of the normal physiology and diseases of the aerodigestive tract and (2) connective tissue and proteoglycans in health and disease.
To provide knowledge of how reflux of gastric and duodenal juice, a normal physiological event can under certain conditions lead to damage of the aerodigestive tract.
This strand will provide an excellent understanding at a molecular level of structure-function relationships involving proteoglycans, e.g. connective tissue function, and how this changes in disease, in particular osteoarthritis, malaria and cancer cell migration.
Outline Of Syllabus
Students will learn about: the relationships between acid and pepsin production by the stomach, reflux and diseases of the aerodigestive tract, such as GORD, LPR, sinusitis, rhinitis, asthma, vocal fold leukoplakia, laryngomalacia and OME. In addition, they will discuss the experimental evidence for a link between the reflux of gastric juice and lung transplant rejection and the molecular mechanisms for the development of bronchiolitis obliterans syndrome. The mechanisms of other aerodigestive diseases associated with reflux will be investigated. As an example, the link between COVID19 and reflux. As a second molecular theme the students will learn about the structure and functions of cartilage and proteoglycans and the changes that occur in these components in osteoarthritis. They will also learn about the cellular functions of proteoglycans in other tissues.
Themes:
Pepsin isoenzymes, bile acids and acids as inflammatory mediators, mucosal protection of different mucosal types.
Human diseases related to reflux. Connective tissues/proteoglycans. Osteoarthritis. Functions of proteoglycans and related diseases and their roles in malaria.
Learning Outcomes
Intended Knowledge Outcomes
By the end of the module students should be able to:
K1. Describe the normal physiology and aerodigestive tract, at a molecular level, and explain changes that occur in disease, using specific examples.
K2. Describe the connective tissue and proteoglycans at molecular level and explain their roles in health and disease, using specific examples.
K3. Discuss how reflux of gastric juice, a normal physiological event, can under certain conditions lead to damage of the aerodigestive tract.
Intended Skill Outcomes
By the end of the module students should be able to:
S1. Perform subject specific laboratory skills, at a basic level of competence.
S2. Analyse, present and interpret experimental data, using commonly available software .
S3. Critically analyse and appraise literature relevant to the module.
S4. Communicate effectively in a written format
S5. Work effectively within a team
Teaching Methods
Teaching Activities
| Category | Activity | Number | Length | Student Hours | Comment |
|---|---|---|---|---|---|
| Guided Independent Study | Assessment preparation and completion | 1 | 33:00 | 33:00 | Preparation and completion of practical report and essay |
| Scheduled Learning And Teaching Activities | Lecture | 14 | 1:00 | 14:00 | In person |
| Scheduled Learning And Teaching Activities | Practical | 1 | 7:00 | 7:00 | In person practical - Provides skills to collect valid and reliable data for understanding, and for inclusion in the lab report |
| Scheduled Learning And Teaching Activities | Small group teaching | 4 | 1:00 | 4:00 | In person seminars to facilitate discussion of module content and check for understanding |
| Guided Independent Study | Independent study | 1 | 92:00 | 92:00 | This includes preparing lecture material notes, reading and revision |
| Total | 150:00 |
Teaching Rationale And Relationship
Lectures convey the core scientific content and an indication of the scope of the course as a basis for guided independent study. Small group teaching encourages increased understanding of the material, provides opportunity for discussion, problem solving and aids the development of critical skills. The practical provides experience in relevant laboratory skills and practical demonstrations to support the core material, provide experience in computer-based presentation skills, and places basic scientific knowledge in a clinical context. The written assessments encourage use of the scientific literature at a deeper level than that presented in lectures promoting scientific discrimination of the literature, individual creative work and opportunities to teach and learn through collective study.
Reading Lists
Assessment Methods
The format of resits will be determined by the Board of Examiners
Exams
| Description | Length | Semester | When Set | Percentage | Comment |
|---|---|---|---|---|---|
| Written Examination | 45 | 2 | A | 45 | In-person invigilated handwritten essay exam (45%), choice of one from two questions (45 mins). Part 2 of the 2 exams to be scheduled together. (Inspera to be open for the duration of the examination (90mins). |
| Digital Examination | 45 | 2 | A | 25 | In-person invigilated Inspera digital exam (45 mins) (25%) Quiz format max 60 questions. Part 1 of 2 exams to be scheduled together. Inspera to be open for the duration of the exam (total 90 mins). |
Other Assessment
| Description | Semester | When Set | Percentage | Comment |
|---|---|---|---|---|
| Essay | 2 | M | 20 | Essay (850 words) |
| Practical/lab report | 2 | M | 10 | Structured, guided answers based on practical content, completed in small teams. |
Assessment Rationale And Relationship
The end of semester examination assess knowledge and understanding of the course material and the ability to work under time limited conditions.
The in-course essay promotes revision, deeper learning and scientific discrimination of the literature, and provides an opportunity to consolidate knowledge and identify areas of weakness in learning and teaching and provides writing practice to support the end of module exam.
The practical report tests critical analysis skills, problem-solving, data interpretation, computer-based presentation skills and written communication skills.
Timetable
- Timetable Website: www.ncl.ac.uk/timetable/
- PSC2016's Timetable
Past Exam Papers
- Exam Papers Online : www.ncl.ac.uk/exam.papers/
- PSC2016's past Exam Papers
General Notes
Original Handbook text:
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