Module Catalogue 2018/19

BGM2056 : DNA Replication, recombination and Repair

  • Offered for Year: 2018/19
  • Module Leader(s): Dr Simon Whitehall
  • Lecturer: Dr Heath Murray
  • Owning School: Biomedical Sciences
  • Teaching Location: Newcastle City Campus
Semester 2 Credit Value: 10
ECTS Credits: 5.0
Pre Requisites
Pre Requisite Comment


Co Requisites
Co Requisite Comment



1. To provide a sound understanding of the molecular mechanisms underlying the replication, repair and recombination of DNA and to demonstrate the unique importance of the accuracy of these processes.

2. To provide a framework for understanding the different types of DNA damage, the mechanisms by which they are repaired and the diseases that result from defects in these repair processes.

Outline Of Syllabus

This module provides an understanding of the following key DNA-dependent processes:

accurate replication of the genome and recombination;
mechanisms of genetic variation;
repair of DNA damage;
results of failure to correct DNA damage (e.g. mutation, genetic instability, cancer).
development of genetics diseases (e.g. developmental disorders, cancer predisposition and premature ageing)

Learning Outcomes

Intended Knowledge Outcomes

1. Explain the importance of the accuracy during DNA replication and the need to correct errors.
2. Describe the molecular mechanisms of DNA replication initiation and elongation.
3. Describe the various types of damage that occur to DNA.
4. Compare and contrast the molecular mechanisms by which damaged DNA may be repaired.
5. Describe the associations between defects in human DNA repair processes and human diseases.
6. Explain how DNA damage sensitivity assays can be used to characterize DNA repair pathways.

Intended Skill Outcomes

Subject specific
Determination of UV survival curves

Determination of UV survival curves

General laboratory practice
General numeracy skills

Graduate Skills Framework

Graduate Skills Framework Applicable: Yes
  • Cognitive/Intellectual Skills
    • Critical Thinking : Assessed
    • Data Synthesis : Assessed
    • Active Learning : Present
    • Numeracy : Assessed
    • Literacy : Assessed
  • Interaction
    • Communication
      • Written Other : Assessed
    • Team Working
      • Collaboration : Present

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Scheduled Learning And Teaching ActivitiesLecture121:0012:00
Scheduled Learning And Teaching ActivitiesPractical16:006:00The practical runs over 2 days
Scheduled Learning And Teaching ActivitiesSmall group teaching11:001:00Seminar - Discussion on practical results
Guided Independent StudyIndependent study181:0081:00
Teaching Rationale And Relationship

The lectures will be used to introduce the intended knowledge outcomes for the module. These will be reinforced by the material covered in the data analysis and practical sessions. The seminar will reinforce the lecture material and acts as a feedback session for the practical and data-handing exercise.

Reading Lists

Assessment Methods

The format of resits will be determined by the Board of Examiners

Description Length Semester When Set Percentage Comment
Written Examination752A80EMI (30%): 25 minutes Essay x 1 (70%): 50 minutes.
Other Assessment
Description Semester When Set Percentage Comment
Practical/lab report2M20Students will gain experience in the accurate recording and also with determination of UV survival curves
Assessment Rationale And Relationship

The assessments will test understanding of the material delivered, as well as providing training in key laboratory and
numeracy skills.


Past Exam Papers

General Notes

Original Handbook text:

Disclaimer: The information contained within the Module Catalogue relates to the 2018/19 academic year. In accordance with University Terms and Conditions, the University makes all reasonable efforts to deliver the modules as described. Modules may be amended on an annual basis to take account of changing staff expertise, developments in the discipline, the requirements of external bodies and partners, and student feedback. Module information for the 2018/19 entry will be published here in early-April 2018. Queries about information in the Module Catalogue should in the first instance be addressed to your School Office.