CHY2103 : Medicinal Chemistry and Drug Design (Inactive)
CHY2103 : Medicinal Chemistry and Drug Design (Inactive)
- Inactive for Year: 2024/25
- Module Leader(s): Dr Celine Cano
- Lecturer: Dr Ian Hardcastle
- Owning School: Natural and Environmental Sciences
- Teaching Location: Newcastle City Campus
Semesters
Your programme is made up of credits, the total differs on programme to programme.
| Semester 1 Credit Value: | 10 |
| ECTS Credits: | 5.0 |
| European Credit Transfer System | |
Pre-requisite
Modules you must have done previously to study this module
| Code | Title |
|---|---|
| CHY1101 | Basic Organic Chemistry XX |
Pre Requisite Comment
N/A
Co-Requisite
Modules you need to take at the same time
| Code | Title |
|---|---|
| CHY2101 | Organic Chemistry |
Co Requisite Comment
N/A
Aims
To equip students with:
• knowledge and understanding of drug-receptor interactions, enzyme chemistry and the
principles of drug design and action
• understand the basic concepts and uses of computational chemistry
• appreciate the validity of results based on appropriateness of theory levels
• be able to use ChemDraw as an interface to the GAMESS package
• know how to generate theoretical spectroscopic data for an arbitrary compound
Outline Of Syllabus
Principles of Medicinal Chemistry and Enzyme Action
Dr C Cano
* Principles of medicinal chemistry. Pharmacokinetics; Lipinski’s rule of five;
Pharmacodynamics; Drug-receptor interactions
* Enzymes. What are enzymes?; How do they work?; Mechanisms of enzyme catalysis;
Enzyme inhibition and co-enzyme catalysis
* Physicochemical properties of drugs. Ionisation constants; Aqueous solubility;
Fick’s Law of diffusion; The cell membrane and lipophilicity; Partition and
distribution coefficients
* Isosterism and bioisosterism. Functional group modifications
* Case studies – Design of small molecule enzyme inhibitors
Drug Design
Dr I Hardcastle
* Drug discovery and SARs
* Lead optimisation
* Mechanisms of enzyme inhibition
* Case studies in drug discovery
* Introduction to Structure Based Drug Design using CCP4 Molecular Graphics including
a computer workshop with hands on ligand-bound protein crystal structures)
Learning Outcomes
Intended Knowledge Outcomes
• understand drug-receptor interactions and theories
• understand the principles of enzyme mechanism and knowledge of some specific examples
• be familiar with quantitative structure activity relationships
• understand how enzyme inhibitors work
Intended Skill Outcomes
Subject-specific or professional skills, able to :
• recognise specific drug types
Cognitive or intellectual skills, able to :
• suggest mechanisms for enzyme actions
Key skills, able to:
• solve problems in aspects of medicinal chemistry
Teaching Methods
Teaching Activities
| Category | Activity | Number | Length | Student Hours | Comment |
|---|---|---|---|---|---|
| Scheduled Learning And Teaching Activities | Lecture | 11 | 1:00 | 11:00 | Office hour drop in sessions |
| Guided Independent Study | Assessment preparation and completion | 1 | 7:00 | 7:00 | Formative online coursework (0%) |
| Structured Guided Learning | Lecture materials | 16 | 1:00 | 16:00 | Online - A combination of short recordings of lecture material and text published on VLE each week |
| Structured Guided Learning | Lecture materials | 2 | 0:30 | 1:00 | Online module introduction and familiarisation with the module topics and delivery |
| Guided Independent Study | Directed research and reading | 16 | 0:30 | 8:00 | Online - students will receive relevant reading for module topics throughout the semester |
| Structured Guided Learning | Academic skills activities | 1 | 4:00 | 4:00 | Online - ChemDraw and CCP4MG tutorials and practice |
| Guided Independent Study | Independent study | 2 | 10:00 | 20:00 | 2 x Online coursework (50% each) |
| Guided Independent Study | Independent study | 1 | 30:30 | 30:30 | Background reading and research |
| Scheduled Learning And Teaching Activities | Module talk | 1 | 0:30 | 0:30 | Module introduction by module team |
| Scheduled Learning And Teaching Activities | Module talk | 4 | 0:30 | 2:00 | Online - feedback on formative coursework, case studies, student's Q+A |
| Total | 100:00 |
Jointly Taught With
| Code | Title |
|---|---|
| CHY2003 | Topics in Chemistry |
Teaching Rationale And Relationship
Students acquire knowledge and understanding through online lectures and materials. Problem solving skills are introduced and practised.
Reading Lists
Assessment Methods
The format of resits will be determined by the Board of Examiners
Other Assessment
| Description | Semester | When Set | Percentage | Comment |
|---|---|---|---|---|
| Written exercise | 1 | M | 50 | Alternate online assessment |
| Written exercise | 1 | M | 50 | Alternate online assessment |
Formative Assessments
Formative Assessment is an assessment which develops your skills in being assessed, allows for you to receive feedback, and prepares you for being assessed. However, it does not count to your final mark.
| Description | Semester | When Set | Comment |
|---|---|---|---|
| Written exercise | 1 | M | Formitive coursework |
Assessment Rationale And Relationship
The two pieces of summative coursework and one formative piece will test the student's knowledge and understanding of both the medicinal and the modelling lecture material.
Study Abroad students to take their exam before the semester 1 exam period, in which case the format of the paper may differ from that shown in the MOF. Study Abroad students should contact the school to discuss this.
Timetable
- Timetable Website: www.ncl.ac.uk/timetable/
- CHY2103's Timetable
Past Exam Papers
- Exam Papers Online : www.ncl.ac.uk/exam.papers/
- CHY2103's past Exam Papers
General Notes
Original Handbook text:
Welcome to Newcastle University Module Catalogue
This is where you will be able to find all key information about modules on your programme of study. It will help you make an informed decision on the options available to you within your programme.
You may have some queries about the modules available to you. Your school office will be able to signpost you to someone who will support you with any queries.
Disclaimer
The information contained within the Module Catalogue relates to the 2024 academic year.
In accordance with University Terms and Conditions, the University makes all reasonable efforts to deliver the modules as described.
Modules may be amended on an annual basis to take account of changing staff expertise, developments in the discipline, the requirements of external bodies and partners, and student feedback. Module information for the 2025/26 entry will be published here in early-April 2025. Queries about information in the Module Catalogue should in the first instance be addressed to your School Office.