Module Catalogue 2018/19

CHY3103 : Chemotherapy (Inactive)

  • Inactive for Year: 2018/19
  • Module Leader(s): Dr Celine Cano
  • Lecturer: Professor Bernard Golding
  • Owning School: Natural and Environmental Sciences
  • Teaching Location: Newcastle City Campus
Semester 2 Credit Value: 10
ECTS Credits: 5.0
Pre Requisites
Code Title
CHY2101Organic Chemistry
CHY2103Medicinal Chemistry and Drug Design
CHY3102Chemical Toxicology
Pre Requisite Comment


Co Requisites
Co Requisite Comment



To introduce the basic concepts of the aetiology of cancer and pathogenic disease; to impart an understanding of the host-pathogen relationship, and the concepts of selective toxicity and resistance; to equip students with an understanding of the basic principles of chemotherapy of cancer and infectious disease; to provide an understanding of the molecular mechanisms underpinning the action of anticancer and anti-infective drugs

Outline Of Syllabus

Cancer Chemotherapy
Dr C Cano

1 Introduction to cancer
2 DNA reactive drugs
3 Antimetabolites
4 DNA Topoisomerase inhibitors
5 Mitotic poisons
6 DNA Repair Enzymes
7 Antiendocrine drugs
8 Current approaches to cancer chemotherapy
9 New thearapies: Targetting receptor tyrosine kinase signalling
10 Kinase inhibitors case studies

Chemotherapy of Infectious Diseases
Professor RJ Griffin

1 Introduction and historical overview
2 Principles of antimicrobial chemotherapy
3 Antibacterial agents – Penicillin and related β-lactam
4 Antibacterial agents – Glycopeptides, quinolones, and oxazolidinones
5 Antifungal agents – Polyenes and azoles
6 Antifungal agents – Azoles and other antifungals
7 Metronidazole
8 Malaria and its treatment
9 Antiviral chemotherapy
10 Acyclovir and maraviroc

Learning Outcomes

Intended Knowledge Outcomes

• understand the basic principles of chemotherapy
• know about the various classes of antitumour and anti-infective agents
• understand the mechanism of action of chemotherapeutic agents at the molecular level
• know about the chemical structures of the more common pharmacophores of anticancer and anti-infective drugs
• understand selective toxicity and resistance mechanisms
• understand the mechanism of action of defined drugs
• understand therapy based on the molecular pathology of disease

Intended Skill Outcomes

Subject-specific or professional skills, able to;
• recognise and draw chemical structures of common anticancer and anti-infective drugs
• draw mechanisms to explain activity of chemotherapeutic agents.

Key skills, able to:
• take accurate notes

Graduate Skills Framework

Graduate Skills Framework Applicable: Yes
  • Cognitive/Intellectual Skills
    • Active Learning : Present
    • Literacy : Present
  • Self Management
    • Self Awareness And Reflection : Present
    • Personal Enterprise
      • Initiative : Present
      • Independence : Present
      • Problem Solving : Present
  • Interaction
    • Communication
      • Interpersonal : Present
      • Written Other : Assessed

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Guided Independent StudyAssessment preparation and completion161:2061:20Background reading and practice past paper examination questions
Guided Independent StudyAssessment preparation and completion200:5016:40Revision of end of semester examination
Guided Independent StudyAssessment preparation and completion12:002:00End of semester examination
Scheduled Learning And Teaching ActivitiesLecture201:0020:00N/A
Jointly Taught With
Code Title
CHY3109Advanced Medicinal Chemistry
CHY8823Theory and Practice of Chemotherapy
Teaching Rationale And Relationship

Students acquire an understanding of the subject through attendance and participation in lectures. An understanding of the topics is reinforced by problem solving, and critical background reading of the scientific literature.

Reading Lists

Assessment Methods

The format of resits will be determined by the Board of Examiners

Description Length Semester When Set Percentage Comment
Written Examination1202A100N/A
Exam Pairings
Module Code Module Title Semester Comment
CHY3109Advanced Medicinal Chemistry2N/A
CHY8823Theory and Practice of Chemotherapy2N/A
Assessment Rationale And Relationship

The examination will assess the student's knowledge and understanding of the basic principles of the subject.


Past Exam Papers

General Notes

Original Handbook text:

Disclaimer: The information contained within the Module Catalogue relates to the 2018/19 academic year. In accordance with University Terms and Conditions, the University makes all reasonable efforts to deliver the modules as described. Modules may be amended on an annual basis to take account of changing staff expertise, developments in the discipline, the requirements of external bodies and partners, and student feedback. Module information for the 2018/19 entry will be published here in early-April 2018. Queries about information in the Module Catalogue should in the first instance be addressed to your School Office.