NES8802 : Drug Metabolism and Toxicology
NES8802 : Drug Metabolism and Toxicology
- Offered for Year: 2024/25
- Module Leader(s): Professor Mike Waring
- Lecturer: Dr Kate Harris
- Owning School: Natural and Environmental Sciences
- Teaching Location: Newcastle City Campus
Semesters
Your programme is made up of credits, the total differs on programme to programme.
| Semester 1 Credit Value: | 10 |
| ECTS Credits: | 5.0 |
| European Credit Transfer System | |
Pre-requisite
Modules you must have done previously to study this module
Pre Requisite Comment
BSc in chemistry or related subject
Co-Requisite
Modules you need to take at the same time
Co Requisite Comment
N/A
Aims
To introduce the principles of pharmacokinetics, drug metabolism and toxicology; to understand the importance of optimising these parameters in drug discovery; to understand the chemical basis of drug metabolism and its importance in drug discovery; to equip students with a knowledge and understanding of the mechanism of toxicity of drug molecules and other the environmental toxins
Outline Of Syllabus
Pharmacokinetics and drug metabolism (Professor M Waring)
Principles of pharmacokinetics
Processes and mechanisms of drug metabolism
Selected case studies in drug metabolism
Toxicology (Dr Kate Madden)
Principles of Toxicology and toxicokinetics
Critical toxicological issues for drug discovery
Allergens and reactive metabolites
Ion channels – hERG and acetyl choline signalling
Carcinogenesis
Learning Outcomes
Intended Knowledge Outcomes
• understand the principles of adsorption, distribution, metabolism and excretion of chemicals
• understand of the essentials of pharmacokinetics/toxicokinetics
• understand how chemicals interact with DNA, proteins and glutathione
• know about the mechanisms of carcinogenesis of selected chemicals
• know about the toxicology of selected substances
Intended Skill Outcomes
Subject specific or professional skills, able to:
• draw chemical structures of a range of toxic substances and their metabolites
• use curly arrows and fish-hook arrow in reaction mechanisms
Cognitive or intellectual skills, able to:
• solve problems of reaction mechanism relevant to toxicology
Key skills, able to:
• communicate in written work
• communicate aspects of toxicology by group oral presentation
Teaching Methods
Teaching Activities
| Category | Activity | Number | Length | Student Hours | Comment |
|---|---|---|---|---|---|
| Guided Independent Study | Assessment preparation and completion | 12 | 1:00 | 12:00 | Online materials via Canvas |
| Scheduled Learning And Teaching Activities | Lecture | 12 | 1:00 | 12:00 | PiP lectures |
| Guided Independent Study | Assessment preparation and completion | 1 | 2:00 | 2:00 | End of Semester examination |
| Guided Independent Study | Assessment preparation and completion | 1 | 20:00 | 20:00 | Revision for end of Semester 1 examination |
| Guided Independent Study | Assessment preparation and completion | 2 | 10:00 | 20:00 | Online assessments - Structured literature exercise: case study and literature reading |
| Guided Independent Study | Independent study | 1 | 34:00 | 34:00 | Independent study |
| Total | 100:00 |
Teaching Rationale And Relationship
Students acquire knowledge and understanding through online lecture content and live module talks. Problem-solving skills are practiced in module talks and in private study.
Reading Lists
Assessment Methods
The format of resits will be determined by the Board of Examiners
Exams
| Description | Length | Semester | When Set | Percentage | Comment |
|---|---|---|---|---|---|
| Written Examination | 120 | 1 | A | 50 | PiP exam |
Other Assessment
| Description | Semester | When Set | Percentage | Comment |
|---|---|---|---|---|
| Computer assessment | 1 | M | 50 | Online assessment |
Formative Assessments
Formative Assessment is an assessment which develops your skills in being assessed, allows for you to receive feedback, and prepares you for being assessed. However, it does not count to your final mark.
| Description | Semester | When Set | Comment |
|---|---|---|---|
| Prob solv exercises | 1 | M | Online canvas quiz |
Assessment Rationale And Relationship
The exam will test the student’s knowledge and understanding of the coursework as well as information literacy and presentation skills.
Formative assessment to allow student to test their understanding of module so far.
Study Abroad students may request to take their exam before the semester 1 exam period, in which case the format of the paper may differ from that shown in the MOF. Study Abroad students should contact the school to discuss this.
Timetable
- Timetable Website: www.ncl.ac.uk/timetable/
- NES8802's Timetable
Past Exam Papers
- Exam Papers Online : www.ncl.ac.uk/exam.papers/
- NES8802's past Exam Papers
General Notes
Original Handbook text:
Welcome to Newcastle University Module Catalogue
This is where you will be able to find all key information about modules on your programme of study. It will help you make an informed decision on the options available to you within your programme.
You may have some queries about the modules available to you. Your school office will be able to signpost you to someone who will support you with any queries.
Disclaimer
The information contained within the Module Catalogue relates to the 2024 academic year.
In accordance with University Terms and Conditions, the University makes all reasonable efforts to deliver the modules as described.
Modules may be amended on an annual basis to take account of changing staff expertise, developments in the discipline, the requirements of external bodies and partners, and student feedback. Module information for the 2025/26 entry will be published here in early-April 2025. Queries about information in the Module Catalogue should in the first instance be addressed to your School Office.