Module Catalogue 2022/23

ONC8022 : Cancer: Cell, Molecular Biology & Genetics (E-learning)

  • Offered for Year: 2022/23
  • Module Leader(s): Professor John Lunec
  • Co-Module Leader: Dr Kelly Coffey
  • Owning School: FMS Graduate School
  • Teaching Location: Off Campus
Semesters
Semester 2 Credit Value: 20
ECTS Credits: 10.0
Pre Requisites
Pre Requisite Comment

N/A

Co Requisites
Co Requisite Comment

N/A

Aims

The aim of this module is to provide knowledge and understanding of the cellular changes that result from damage or alteration of cells at a molecular level. By increasing our understanding of the molecular changes found in cancerous cells we are able to firstly gain a greater understanding of the mechanisms through which cancer is generated and secondly we can design therapeutic strategies that exploit these molecular changes and gain therapeutic benefit in the clinic.

Outline Of Syllabus

This module will cover the following topics:
•Biochemical and molecular basis of cancer
•The multistage nature of cancer, including the roles of the environment and somatic mutation
•The known genetic mechanisms involved in hereditary cancer predispositions and sporadic cancers
•The roles of specific genes involved in the development and progression of cancer by mutational activation of oncogenes and inactivation of tumour suppressor genes
•Molecular targeted approaches to therapies for different cancers, plus predictive and prognostic biomarkers

Learning Outcomes

Intended Knowledge Outcomes

On completion of this module students will be able to:
•Outline the current state of knowledge about the biochemical and molecular basis of cancer
•Describe the multistage nature of cancer and be able to discuss factors which influence this process
•Understand the difference between germline and somatic mutation
•Distinguish among the known genetic mechanisms leading to cancer, including cancer predisposition syndromes
•Discuss contemporary approaches to the development of therapies, including specific molecular alterations in cancer as therapeutic targets and prognostic factors to guide treatment.

Intended Skill Outcomes

On completion of this module students will be able to:
•Undertake a systematic literature and genetic database sourcing of information on the molecular basis of cancer and targeted therapies.

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Guided Independent StudyAssessment preparation and completion220:0040:00Independent assessment preparation
Guided Independent StudyDirected research and reading127:0084:00Online content
Guided Independent StudySkills practice110:0010:00Including systematic literature and genetic database sourcing
Guided Independent StudyReflective learning activity61:006:00eJournal
Guided Independent StudyIndependent study123:0036:00N/A
Guided Independent StudyOnline Discussion122:0024:00Via discussion board
Total200:00
Teaching Rationale And Relationship

Through a series of online tutorials as well as private study (including directed reading, and literature and database sourcing of information), students will gain detailed knowledge and understanding of basic cancer biology and cancer genetics.

Furthermore, students will be encouraged to participate in collaborative learning via the Discussion Board. Personal development will be encouraged through the use of reflective journal postings, shared only with the module leader. As the students proceed through the module, they will complete a number of interactive activities and informative tests that will help to consolidate their understanding of the curriculum.

This will facilitate the development of interpersonal and communication skills as well as team working and peer assessment skills.

Reading Lists

Assessment Methods

The format of resits will be determined by the Board of Examiners

Other Assessment
Description Semester When Set Percentage Comment
Portfolio2M10Participation in collaborative e-learning activities throughout the module
Oral Examination2M45Recorded powerpoint presentation (max 15 slides, max 10 minute presentation)
Computer assessment2M45150 minute online MCQs (Including extended matching and ordering multiple answer)
Formative Assessments
Description Semester When Set Comment
Computer assessment2MMCQ tests
Assessment Rationale And Relationship

The MCQ assessment reviews the students’ achievement of knowledge learning outcomes and consolidates knowledge acquired throughout the module. This assessment is held online and each test is time limited with forced completion once the test is initiated.

The recorded PowerPoint presentation will allow students to synthesise and present data in a way that reflects on the impact of developments in the molecular biology of cancer in their working roles, and demonstrate that learning outcomes of acquired knowledge and understanding have been met. The information and sources used to produce the presentations will show that the skills outcome has been met.

Formative MCQ assessments and worksheet assignments are used throughout the course of the Module.

Assignments are posted on the Discussion Board to encourage students to share resources and promote communal learning.

A participation grade is included to encourage and reward the student's engagement with the
collaborative activities.

Should a student fail the participation assessment and have to undertake a re-sit they will have to
complete a different form of assessment. The student will be asked to look at 2 participation
activities identified by the module leader/team and submit a 500 word written summary (approx. 250 words per activity).

Timetable

Past Exam Papers

General Notes

N/A

Disclaimer: The information contained within the Module Catalogue relates to the 2022/23 academic year. In accordance with University Terms and Conditions, the University makes all reasonable efforts to deliver the modules as described. Modules may be amended on an annual basis to take account of changing staff expertise, developments in the discipline, the requirements of external bodies and partners, and student feedback. Module information for the 2023/24 entry will be published here in early-April 2023. Queries about information in the Module Catalogue should in the first instance be addressed to your School Office.