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Staff Profile
Dr Fiona Cuskin
Lecturer in Metabolic Biochemistry
- Email: fiona.cuskin@ncl.ac.uk
- Address: School of Natural and Environmental Science
Devonshire Building
Newcastle University
Newcastle upon Tyne
NE1 7RU
Publications
- Jin Y, Petricevic M, John A, Raich L, Jenkins H, De Souza LP, Cuskin F, Gilbert HJ, Rovira C, Goddard-Borger ED, Williams SJ, Davies GJ. A β-Mannanase with a Lysozyme-like Fold and a Novel Molecular Catalytic Mechanism. ACS Central Science 2016, 2(12), 896-903.
- Bras JLA, Pinheiro BA, Cameron K, Cuskin F, Viegas A, Najmudin S, Bule P, Pires VMR, Romao MJ, Bayer EA, Spencer HL, Smith S, Gilbert HJ, Alves VD, Carvalho AL, Fontes CMGA. Diverse specificity of cellulosome attachment to the bacterial cell surface. Scientific Reports 2016, 6, 38292.
- Labourel A, Crouch LI, Bras JLA, Jackson A, Rogowski A, Gray J, Yadav MP, Henrissat B, Fontes CMGA, Gilbert HJ, Najmudin S, Basle A, Cuskin F. The Mechanism by Which Arabinoxylanases Can Recognize Highly Decorated Xylans. Journal of Biological Chemistry 2016, 291(42), 22149-22159.
- Cuskin F, Lowe EC, Temple MJ, Zhu YP, Cameron EA, Pudlo NA, Porter NT, Urs K, Thompson AJ, Cartmell A, Rogowski A, Hamilton BS, Chen R, Tolbert TJ, Piens K, Bracke D, Vervecken W, Hakki Z, Speciale G, Munoz-Munoz JL, Day A, Pena MJ, McLean R, Suits MD, Boraston AB, Atherly T, Ziemer CJ, Williams SJ, Davies GJ, Abbott DW, Martens EC, Gilbert HJ. Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism. Nature 2015, 517(7533), 165-169.
- Cuskin F, Baslé A, Ladevèze S, Day AM, Gilbert HJ, Davies GJ, Potocki-Véronèse G, Lowe EC. The GH130 Family of Mannoside Phosphorylases Contains Glycoside Hydrolases That Target β-1,2-Mannosidic Linkages in Candida Mannan. Journal of Biological Chemistry 2015, 290(41), 25023-25033.
- Thompson AJ, Cuskin F, Spears RJ, Dabin J, Turkenburg JP, Gilbert HJ, Davies GJ. Structure of the GH76 alpha-mannanase homolog, BT2949, from the gut symbiont Bacteroides thetaiotaomicron. Acta Crystallographica Section D Biological Crystallography 2015, 71(2), 408-415.
- Cuskin F, Flint JE, Gloster TM, Morland C, Basle A, Henrissat B, Coutinho PM, Strazzulli A, Solovyova AS, Davies GJ, Gilbert HJ. How nature can exploit nonspecific catalytic and carbohydrate binding modules to create enzymatic specificity. Proceedings of the National Academy of Sciences 2012, 109(51), 20889-20894.
- Temple MJ, Cuskin F, Baslé A, Hickey N, Speciale G, Williams SJ, Gilbert HJ, Lowe EC. A Bacteroidetes locus dedicated to fungal 1,6-β-glucan degradation: unique substrate conformation drives specificity of the key endo-1,6-β-glucanase. Journal of Biological Chemistry 2017, 292(25), 10639-10650.
- Abbott DW, Martens EC, Gilbert HJ, Cuskin F, Lowe EC. Coevolution of yeast mannan digestion: Convergence of the civilized human diet, distal gut microbiome, and host immunity. Gut Microbes 2015, 6(5), 334-339.
- Cuskin F, Solovyova AS, Lewis RJ, Race PR. Crystallization and preliminary X-ray analysis of the bacillaene synthase trans-acting acyltransferase PksC. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online 2011, 67(4), 464-466.
- Danne C, Ryzhakov G, Martinez-Lopez M, Ilott NE, Franchini F, Cuskin F, Lowe EC, Bullers SJ, Arthur JSC, Powrie F. A Large Polysaccharide Produced by Helicobacter hepaticus Induces an Anti-inflammatory Gene Signature in Macrophages. Cell Host and Microbe 2017, 22(6), 733-745.e5.