Background

Roles and Responsibilities

NHS clinical consultant.

Research within Institute of Neuroscience.

Undergraduate and postgraduate teaching.

Head of Northern Deanery Postgraduate School of Psychiatry.

Qualifications

MB BS
MD(hons)
MRCPsych

Previous Positions

1.7.2000 to 25.8.2002: Academic Specialist Registrar, Department of Psychiatry,Newcastle University.

1.7.98 - 30.6.2000: Clinical Research Associate, Department of Psychiatry, Newcastle University

Memberships

British Association for Psychopharmacology
Royal College of Psychiatrists
British Medical Association

Research

Research Interests

Structural neuroimaging in affective disorders; Work including MRI volumetric analysis, white matter structural change, diffusion tensor imaging and MR spectroscopy. Specific clinical areas investigated include early and late onset depression, bipolar affective disorder and relation of structural change to HPA axis abnormalities and vascular risk.

Current Work

Member of psychobiology research group.
Investigation of structural brain change in euthymic patients with bipolar affective disorder: Volumetric change, white matter hyperintensities, white matter tract integrity (diffusion tensor MRI) and MRS.

Co-investigator for the ADD (anti-glucocorticoid augmentation of antidepressants in depression) study: http://www.theaddstudy.co.uk/index.html

Future Research

Development of research in affective disorders with focus on neuroimaging.

Research Roles

Development and implementation of protocols for research in affective disorders, particularly using neuroimaging.

Postgraduate student supervision.

Postgraduate Supervision

Structural neuroimaging in psychiatric disorders

Esteem Indicators

Peer reviewer of for academic journals and for grant awards (local and national bodies).

Member of regional committee of Mental Health Foundation - charitable body awarding for research and services in mental health care.

Teaching

Undergraduate Teaching

Stage 3 and stage 4 medical student clinical teaching.

Postgraduate Teaching

Head of Northern Deanery Postgraduate School of Psychiatry

MRes(NEU 8002)course teacher

Northern Region MRCPsych course teaching and module leader.

Publications

• Hibar DP, Westlye LT, Doan NT, Jahanshad N, Cheung JW, Ching CRK, Versace A, Bilderbeck AC, Uhlmann A, Mwangi B, Kramer B, Overs B, Hartberg CB, Abe C, Dima D, Grotegerd D, Sprooten E, Ben E, Jimenez E, Howells FM, Delvecchio G, Temmingh H, Starke J, Almeida JRC, Goikolea JM, Houenou J, Beard LM, Rauer L, Abramovic L, Bonnin M, Ponteduro MF, Keil M, Rive MM, Yao N, Yalin N, Najt P, Rosa PG, Redlich R, Trost S, Hagenaars S, Fears SC, Alonso-Lana S, Van Erp TGM, Nickson T, Chaim-Avancini TM, Meier TB, Elvsashagen T, Haukvik UK, Lee WH, Schene AH, Lloyd AJ, Young AH, Nugent A, Dale AM, Pfennig A, McIntosh AM, Lafer B, Baune BT, Ekman CJ, Zarate CA, Bearden CE, Henry C, Simhandl C, McDonald C, Bourne C, Stein DJ, Wolf DH, Cannon DM, Glahn DC, Veltman DJ, Pomarol-Clotet E, Vieta E, Canales-Rodriguez EJ, Nery FG, Duran FLS, Busatto GF, Roberts G, Pearlson GD, Goodwin GM, Kugel H, Whalley HC, Ruhe HG, Soares JC, Fullerton JM, Rybakowski JK, Savitz J, Chaim KT, Fatjo-Vilas M, Soeiro-De-Souza MG, Boks MP, Zanetti MV, Otaduy MCG, Schaufelberger MS, Alda M, Ingvar M, Phillips ML, Kempton MJ, Bauer M, Landen M, Lawrence NS, Van Haren NEM, Horn NR, Freimer NB, Gruber O, Schofield PR, Mitchell PB, Kahn RS, Lenroot R, Machado-Vieira R, Ophoff RA, Sarro S, Frangou S, Satterthwaite TD, Hajek T, Dannlowski U, Malt UF, Arolt V, Gattaz WF, Drevets WC, Caseras X, Agartz I, Thompson PM, Andreassen OA. Cortical abnormalities in bipolar disorder: An MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group. Molecular Psychiatry 2018, 23(4), 932-942.
• McAllister-Williams RH, Anderson IM, Finkelmeyer A, Gallagher P, Grunze HCR, Haddad PM, Hughes T, Lloyd AJ, Mamasoula C, McColl E, Pearce S, Siddiqi N, Sinha BNP, Steen N, Wainwright J, Winter FH, Ferrier IN, Watson S, ADD Study Team. Antidepressant augmentation with metyrapone for treatment-resistant depression (the ADD study): a double-blind, randomised, placebo-controlled trial. The Lancet Psychiatry 2016, 3(2), 117-127.
• Yalin N, Soeiro-de-Souza MG, Lloyd A, King S, Chaim K, Ferrier N, Hidiroglu C, Lafer B, Machado-Vieira R, Macritchie K, Moreno R, Nery F, Otaduy MC, Ozerdem A, Saricicek A, Kempton M, Young A. Independent confirmation of regional white matter volume reduction in an international sample of euthymic bipolar disorder I patients. In: 18th Annual Conference of the International Society for Bipolar Disorders & 8th Biennial Conference of the International Society for Affective Disorders. 2016, Amsterdam, The Netherlands: Wiley-Blackwell Publishing, Inc.
• Hibar DP, Westlye LT, van Erp TGM, Rasmussen J, Leonardo CD, Faskowitz J, Haukvik UK, Hartberg CB, Doan NT, Agartz I, Dale AM, Gruber O, Kramer B, Trost S, Liberg B, Abe C, Ekman CJ, Ingvar M, Landen M, Fears SC, Freimer NB, Bearden CE, Sprooten E, Glahn DC, Pearlson GD, Emsell L, Kenney J, Scanlon C, McDonald C, Cannon DM, Almeida J, Versace A, Caseras X, Lawrence NS, Phillips ML, Dima D, Delvecchio G, Frangou S, Satterthwaite TD, Wolf D, Houenou J, Henry C, Malt UF, Boen E, Elvsashagen T, Young AH, Lloyd AJ, Goodwin GM, Mackay CE, Bourne C, Bilderbeck A, Abramovic L, Boks MP, van Haren NEM, Ophoff RA, Kahn RS, Bauer M, Pfennig A, Alda M, Hajek T, Mwangi B, Soares JC, Nickson T, Dimitrova R, Sussmann JE, Hagenaars S, Whalley HC, McIntosh AM, Thompson PM, Andreassen OA, Costa Rica Colombia Consortium Gen, ENIGMA Bipolar Disorder Working Gr. Subcortical volumetric abnormalities in bipolar disorder. Molecular Psychiatry 2016, 21(12), 1710-1716.
• Gallagher P, Nilsson J, Finkelmeyer AE, Goshawk M, Macritchie KA, Lloyd AJ, Thompson JM, Porter RJ, Young AH, Ferrier IN, McAllister-Williams RH, Watson S. Neurocognitive intra-individual variability in mood disorders: effects on attentional response time distributions. Psychological Medicine 2015, 45(14), 2985-2997.
• Lloyd AJ, Ali HE, Nesbitt D, Moore PB, Young AH, Ferrier IN. Corpus callosum changes in euthymic bipolar affective disorder. British Journal of Psychiatry 2014, 204(2), 129-136.
• Macritchie KAN, Gallagher P, Lloyd AJ, Bastin ME, Eyre R, Vasudev K, Marshall I, Wardlaw JM, Ferrier IN, Moore PB, Young AH. Periventricular white matter integrity and cortisol levels in healthy controls and in euthymic patients with bipolar disorder: An exploratory analysis. Journal of Affective Disorders 2013, 148(2-3), 249-255.
• McAllister-Williams RH, Smith E, Anderson IM, Barnes J, Gallagher P, Grunze HCR, Haddad PM, House AO, Hughes T, Lloyd AJ, McColl EMM, Pearce SHS, Siddiqi N, Sinha B, Speed C, Steen IN, Wainwright J, Watson S, Winter FH, Ferrier IN. Study protocol for the randomised controlled trial: Antiglucocorticoid augmentation of anti-Depressants in Depression (The ADD Study). BMC Psychiatry 2013, 13, 205.
• Ahuja N, Lloyd AJ. A history of suicide. In: A. Shrivastav, M. Kimbrell, D. Lester, ed. Suicide from a global perspective: public health approaches. Hauppauge, NY: Nova Science Publishers, 2012, pp.1-10.
• Ahuja N, Palanichamy N, Mackin P, Lloyd A. Olanzapine-induced hyperglycaemic coma and neuroleptic malignant syndrome: case report and review of literature. Journal of Psychopharmacology 2010, 24(1), 125-130.
• Cousins DA, Moore PB, Watson S, Harrison L, Ferrier IN, Young AH, Lloyd AJ. Pituitary volume and third ventricle width in euthymic patients with bipolar disorder. Psychoneuroendocrinology 2010, 35(7), 1074-1081.
• Ferrier IN, Lloyd AJ. Practical Guide to Brain Imaging in Bipolar Disorder . In: Young, AH; Ferrier, IN; Michalak, E, ed. Practical Management of Bipolar Disorders. Cambridge: Cambridge University Press, 2010, pp.194-198.
• Mackay CE, Roddick E, Barrick TR, Lloyd AJ, Roberts N, Crow TJ, Young AH, Ferrier IN. Sex dependence of brain size and shape in bipolar disorder: an exploratory study. Bipolar Disorders 2010, 12(3), 306-311.
• Kohler S, Thomas AJ, Lloyd A, Barber R, Almeida OP, O'Brien JT. White matter hyperintensities, cortisol levels, brain atrophy and continuing cognitive deficits in late-life depression. British Journal of Psychiatry 2010, 196(2), 143-149.
• Macritchie KAN, Lloyd AJ, Bastin ME, Vasudev K, Gallagher P, Eyre R, Marshall I, Wardlaw JM, Ferrier IN, Moore PB, Young AH. White matter microstructural abnormalities in euthymic bipolar disorder. British Journal of Psychiatry 2010, 196(1), 52-58.
• Macritchie KAN, Gallagher P, Lloyd AJ, Bastin ME, Vasudev K, Marshall I, Wardlaw JM, Ferrier IN, Moore PB, Young AH. Correlations Between Periventricular White Matter Diffusion Parameters and Salivary Cortisol Levels in Euthymic Bipolar Patients and in Control Subjects. In: Biological Psychiatry: 64th Annual Convention of the Society of Biological Psychiatry. 2009, Vancover, Canada: Elsevier Inc.
• Lloyd AJ, Moore PB, Cousins DA, Thompson JM, McAllister VL, Hughes JH, Ferrier IN, Young AH. White matter lesions in euthymic patients with bipolar disorder. Acta Psychiatrica Scandinavica 2009, 120(6), 481-491.
• Ahuja N, Moorhead SRJ, Lloyd AJ, Cole AJ. Antipsychotic-induced hyperprolactinemia and delusion of pregnancy. Psychosomatics 2008, 49(2), 163-167.
• Ahuja N, Vasudev K, Lloyd A. Hyperprolactinemia and delusion of pregnancy. Psychopathology 2008, 41(1), 65-68.
• Ahuja N, Lloyd AJ. Letter to the editor. Annals of Clinical Psychiatry 2008, 20(2), 113-114.
• Ahuja N, Lloyd AJ. On catatonia, seizures, and bradycardia. Psychosomatics 2008, 49(1), 86.
• Armstrong D, Ahuja N, Lloyd AJ. Quetiapine-related dysphagia. Psychosomatics 2008, 49(5), 450-452.
• Vasudev K, Lloyd A, Ahuja N. Repeat prescribing in secondary care: are there any standards?. Psychiatric Bulletin 2008, 32(12), 474.
• Ahuja N, Lloyd AJ. Worsening of psychosis in a 30 year old man with undifferentiated schizophrenia. Annals of Clinical Psychiatry 2008, 20(2), 113-114.
• Ahuja N, Lloyd AJ. Antibiomania and ciprofloxacin-induced mania. Psychosomatics 2007, 48(4), 363.
• Ahuja N, Lloyd AJ. Aripiprazole and worsening of psychosis: A case report [9]. Journal of Clinical Psychiatry 2007, 68(5), 805-806.
• Ahuja N, Carroll BT, Lloyd AJ. Catatonia associated with systemic lupus erythematosus. Psychiatry and Clinical Neurosciences 2007, 61(4), 450-451.
• Ahuja N, Lloyd A. Self-cannibalism: An unusual case of self-mutilation. Australian and New Zealand Journal of Psychiatry 2007, 41(3), 294-295.
• Curtis VA, Thompson JM, Seal ML, Monks PJ, Lloyd AJ, Harrison L, Brammer MJ, Williams SCR, Murray RM, Young AH, Ferrier IN. The nature of abnormal language processing in euthymic bipolar I disorder: Evidence for a relationship between task demand and prefrontal function. Bipolar Disorders 2007, 9(4), 358-369.
• Vasudev A, Watson S, Lloyd AJ, Harrison CL, Young AH. Bipolar prescription patterns: a cohort follow-up analysis. Quarterly Journal of Mental Health 2006, 1(1).
• Eyre R, MacRitchie KAN, Young AH, Moore PB, Ferrier IN, Bastin ME, Marshall I, Lloyd AJ. Diffusion tensor imaging changes in the corpus callosum of euthymic bipolar subjects. In: Bipolar Disorders: 2nd Biennial Conference of the International Society for Bipolar Disorders. 2006, Edinburgh, UK: Wiley-Blackwell Publishing, Inc.
• Lloyd AJ, Frangou S, Moore PB, MacAllister VL, Ferrier IN, Young AH. Increased amygdala size in adult euthymic bipolar patients on voxel-based morphometry. In: Biological Psychiatry: 61st Annual Convention of the Society of Biological Psychiatry. 2006, Toronto, Canada: Elsevier Inc.
• Cousins DA, Harrison LL, Moore BP, McAllister V, Ferrier IN, Young AH, Lloyd AJ. Pituitary volume and third ventricle width in euthymic patients with bipolar affective disorder. In: Biological Psychiatry: 61st Annual Convention of the Society of Biological Psychiatry. 2006, Toronto, Canada: Elsevier Inc.
• Macritchie KAN, Lloyd AJ, Bastin ME, Vasudev K, Marshall I, Moore PB, Ferrier IN, Young AH. Pre-frontal mean diffusivity is increased in non-lithium-treated euthymic bipolar patients. In: Biological Psychiatry: 61st Annual Convention of the Society of Biological Psychiatry. 2006, Toronto, Canada: Elsevier Inc.
• Lloyd AJ, Ali HE, Vasudev K, Moore PB, MacAllister VL, Ferrier IN, Young AH. Reduced corpus callosum area and MRI signal intensity in bipolar affective disorder. In: Biological Psychiatry: 61st Annual Convention of the Society of Biological Psychiatry. 2006, Toronto, Canada: Elsevier Inc.
• Mackay CE, Roddick E, Barrick TR, Roberts N, Crow TJ, Lloyd AJ, Young AH, Ferrier N. Sex differences in lobe volumes in bipolar disorder. In: 13th Biennial Winter Workshop on Schizophrenia Research. 2006, Davos, Switzerland: Schizophrenia Research: Elsevier.
• Lloyd A. [abstract] White matter hyperintensities in late-life depression. International Psychogeriatrics 2005, 17(s2), 65.
• Lloyd AJ, Young AH. Combination therapy in bipolar disorder. In: Kasper, S and Hirschfield, R, ed. Handbook of Bipolar Disorder: Diagnosis and Therapeutic Approaches. London: Taylor & Francis, 2005.
• Macritchie K, Vasudev K, Lloyd AJ, Marshall I, Bastin M, Moore PB, Young AH. [abstract] Anterior cingulate and striatal N-acetyl aspartate (NAA) in bipolar disorder. Acta Psychiatrica Scandinavica 2004, 110(s423), 27.
• Lloyd AJ, Moore PB, Cousins DA, Thompson JM, McAllister VL, Hughes JH, Ferrier IN, Young AH. [abstract] MRI hyperintensities in euthymic bipolar patients and controls. Acta Psychiatrica Scandinavica 2004, 110(s423), 26.
• Monks PJ, Thompson JM, Bullmore ET, Suckling J, Brammer MJ, Williams SCR, Simmons A, Giles N, Lloyd AJ, Harrison CL, Seal M, Murray RM, Ferrier IN, Young AH, Curtis VA. A functional MRI study of working memory task in euthymic bipolar disorder: Evidence for task-specific dysfunction. Bipolar Disorders 2004, 6(6), 550-564.
• O'Brien JT, Lloyd A, McKeith I, Gholkar A, Ferrier N. A Longitudinal Study of Hippocampal Volume, Cortisol Levels, and Cognition in Older Depressed Subjects. American Journal of Psychiatry 2004, 161(11), 2081-2090.
• Firbank MJ, Lloyd AJ, Ferrier N, O'Brien JT. A volumetric study of MRI signal hyperintensities in late-life depression. American Journal of Geriatric Psychiatry 2004, 12(6), 606-612.
• Lloyd AJ, Ferrier IN, Barber R, Gholkar A, Young AH, O'Brien JT. Hippocampal volume change in depression: Late- and early-onset illness compared. British Journal of Psychiatry 2004, 184(6), 488-495.
• Vasudev A, Watson S, Harrison CL, Lloyd A, Young AH. Bipolar prescription patterns. In: Journal of Psychopharmacology: Summer Meeting of the British Association for Psychopharmacology. 2003, Cambridge, UK: Sage Publications Ltd.
• Lloyd AJ, Harrison CL, Ferrier IN, Young AH. The pharmacological treatment of bipolar affective disorder: Practice is improving but could still be better. Journal of Psychopharmacology 2003, 17(2), 230-233.
• Lloyd AJ. [abstract] 2 grades, 2 exams, 6 specialties; psychiatric training: UK & Ireland. European Psychiatry 2002, 17(s1), 93S.
• Monks PJ, Thompson JM, Lloyd AJ, Harrison CL, Suckling J, Bullmore ET, Brammer MJ, Williams SCR, Simmons A, Murray RM, Ferrier IN, Young AH, Curtis VA. Altered functional brain activation during word generation in euthymic bipolar subjects. In: Journal of Affective Disorders: 1st Biennial Conference on International Society for Affective Disorders (ISAD). 2002, Taormina, Sicily: Elsevier BV.
• Lloyd AJ, McGuckin EA, Barnett NA, Gholkar A, McKeith IG, Young AH, Ferrier IN, O'Brien JT. Increased salivary cortisol in late- but not early-onset depression: Relationship with hippocampal volume. In: Journal of Psychopharmacology: Summer Meeting of the British Association for Psychopharmacology. 2002, Harrogate: Sage Publications Ltd.
• Fiorillo A, Carrà G, Hanon C, Lloyd AJ, Ozturk O, Perris F, Vandenberghe J. La Formazione in Psichiatria in diversi Paesi Europei. Studi di Psychiatria 2002, 4(3).
• Day E, Grimmer C, Lloyd AJ. Psychiatry training in Europe: a brief history of the European Federation of Psychiatric Trainees. Psychiatric Bulletin 2002, 26(4), 152-154.
• Lloyd A, Harriram H, Thompson JM, Ferrier IN, Young AH, McAllister V, Moore PB. White matter abnormalities in euthymic subjects with bipolar affective disorder. In: Journal of Psychopharmacology: Summer Meeting of the British Association for Psychopharmacology. 2002, Harrogate: Sage Publications Ltd.
• Middelkoop HAM, Van Der Flier WM, Burton EJ, Lloyd AJ, Paling S, Barber R, Ballard C, McKeith IG, O'Brien JT. Dementia with Lewy bodies and AD are not associated with occipital lobe atrophy on MRI. Neurology 2001, 57(11), 2117-2120.
• Lloyd AJ, Grace JB, Jaros E, Perry RH, Fairbairn AF, Swann AG, O'Brien JT, McKeith IG. Depression in late life, cognitive decline and white matter pathology in two clinico-pathologically investigated cases. International Journal of Geriatric Psychiatry 2001, 16(3), 281-287.
• Monks PJ, Thompson JM, Lloyd AJ, Harrison CL, Bullmore ET, Brammer MJ, Williams SCR, Simmons A, Murray RM, Ferrier IN, Young AH, Curtis VA. Using fMRI to study euthymic bipolar patients: a new paradigm for investigating language processing. In: Seventh annual meeting of the Organization for Human Brain Mapping. 2001, Brighton, United Kingdom: Academic Press.
• Monks PJ, Thompson JM, Lloyd AJ, Harrison CL, Bullmore ET, Brammer MJ, Williams SCR, Simmons A, Murray RM, Ferrier IN, Young AH, Curtis VA. Using fMRI to study euthymic bipolar patients: studies of verbal fluency. In: NeuroImage. 2001, Academic Press.