Background

Background

• Consultant Cardiologist with major interest in heart failure, Freeman Hospital since July 2004.
• Honorary Professor of Heart Failure, Newcastle University

Roles and Responsibilities

• NHS Consultant with responsibility for advanced heart failure supporting heart transplant and ventricular assist device programmes at the Freeman Hospital

Area of expertise

• Heart failure

Qualifications

• MB BCh (2.2 Hons): Royal College of Surgeons in Ireland, 1986
• MRCPI 1988
• MD (NUI) 1998
• Fellow Royal College of Physicians of Ireland
• Fellow American College of Cardiology
• Specialist Register in Cardiology 2004

Previous Positions

• 1997-2004 Assistant Professor of Medicine, Section of Heart Failure and Transplantation Cardiology, University of Pittsburgh School of Medicine
• Training at: University of Pittsburgh and Johns Hopkins University USA, and Beaumont Hospital, Dublin

Honours and Awards

• Mentored Clinical Scientist Development Award, US National Institutes of Health, 1999-2004
• British Heart Foundation Clinical Leave Research Fellowship 2012-15 

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Research

Research Interests:

Heart Failure: Our research is in the broadest sense related to heart failure, though more specifically related to the physiological and molecular mechanisms of left ventricular dysfunction. 

Left ventricular assist devices: In some patients with end-stage and refractory heart failure, implantable electrically powered mechanical pumps called left ventricular assist devices may offer the potential to live longer, feel better, and potential to receive a heart transplant after a period of support. Based at the Freeman Hospital we have a well established, internationally recognised ventricular assist device programme. Our research focuses on recovering left ventricular function on these devices, long term consequences of support on these devices, mechanisms of exercise intolerance in patients with these devices, and use in special populations of patients such as those with adult congenital heart disease.

Heart Failure and Ageing: Heart failure has many forms though overall it is very much a disease of the elderly. Why some elderly subjects suffer from heart failure is not clear. We are conducting research with state of the art magnetic resonance imaging to determine how the heart changes with normal ageing, and how conditions such as hypertension might predispose to heart failure in later life. Ultimately we aim to develop interventions that prevent heart failure developing, and we are currently interested in the role of exercise interventions.

Cardiomyopathy: Some forms of cardiomyopathy are genetic in origin such as the cardiomyopathies associated with muscular dystrophy, and hypertrophic cardiomyopathy. We are conducting research to determine mechanisms of the cardiomyopathy (for instance with magnetic resonance imaging) and studying exercise interventions to help patients with hypertrophic cardiomyopathy. In conjunction with scientists from the Biosciences Institute we are looking at molecular mechanisms of the development human dilated cardiomyopathy.

Funding: EU, British Heart Foundation, Heart Research UK, Newcastle Biomedical Research Centre, US National Institutes of Health, American Heart Association.

 

Publications

• Smole T, Zunkovic B, Piculin M, Kokalj E, Robnik-Sikonja M, Kukar M, Fotiadis DI, Pezoulas VC, Tachos NS, Barlocco F, Mazzarotto F, Popovic D, Maier L, Velicki L, MacGowan GA, Olivotto I, Filipovic N, Jakovljevic DG, Bosnic Z. A machine learning-based risk stratification model for ventricular tachycardia and heart failure in hypertrophic cardiomyopathy. Computers in Biology and Medicine 2021, 135, 104648.
• Wibowo PG, Charman SJ, Okwose NC, Velicki L, Popovic D, Hollingsworth KG, Macgowan GA, Jakovljevic DG. Association between cardiac high-energy phosphate metabolism and whole body metabolism in healthy female adults. Physiological Research 2021, 70(3), 393-399.
• Beska B, Coakley D, Macgowan G, Adams-Hall J, Wilkinson C, Kunadian V. Frailty and quality of life after invasive management for non-ST elevation acute coronary syndrome. Heart 2021, 108(3), 203-211.
• Charman SJ, Velicki L, Okwose NC, Harwood A, McGregor G, Ristic A, Banerjee P, Seferovic PM, MacGowan GA, Jakovljevic DG. Insights into heart failure hospitalizations, management, and services during and beyond COVID-19. ESC Heart Failure 2021, 8(1), 175-182.
• Gerhard EF, Wang L, Singh R, Schueler S, Genovese LD, Woods A, Tang D, Smith NR, Psotka MA, Tovey S, Desai SS, Jakovljevic DG, MacGowan GA, Shah P. LVAD decommissioning for myocardial recovery: Long-term ventricular remodeling and adverse events. Journal of Heart and Lung Transplantation 2021, 40(12), 1560-1570.
• Bouzas-Cruz N, Koshy A, Gonzalez-Fernandez O, Ferrera-Duran C, Green T, Okwose NC, Woods A, Tovey S, Robinson-Smith N, McDiarmid A, Parry G, Gonzalez-Juanatey JR, Schueler S, Jakovljevic DG, MacGowan G. Markers of Right Ventricular Dysfunction Predict Maximal Exercise Capacity after Left Ventricular Assist Device Implantation. ASAIO Journal 2021, 67(3), 284-289.
• Pandhita BAW, Okwose NC, Koshy A, Fernandez OG, Cruz NB, Eggett C, Velicki L, Popovic D, MacGowan GA, Jakovljevic DG. Noninvasive Assessment of Cardiac Output in Advanced Heart Failure and Heart Transplant Candidates Using the Bioreactance Method. Journal of Cardiothoracic and Vascular Anesthesia 2021, 35(6), 1776-1781.
• Mirza KK, Szymanski MK, Schmidt T, de Jonge N, Brahmbhatt DH, Billia F, Hsu S, MacGowan GA, Jakovljevic DG, Agostoni P, Trombara F, Jorde U, Rochlani Y, Vandersmissen K, Reiss N, Russell SD, Meyns B, Gustafsson F. Prognostic Value of Peak Oxygen Uptake in Patients Supported with Left Ventricular Assist Devices (PRO-VAD). Journal of the American College of Cardiology Heart Failure 2021, 9(10), 758-767.
• Fuller A, Okwose N, Scragg J, Eggett C, Luke P, Bandali A, Velicki R, Greaves L, MacGowan GA, Jakovljevic DG. The effect of age on mechanisms of exercise tolerance: Reduced arteriovenous oxygen difference causes lower oxygen consumption in older people. Experimental Gerontology 2021, 149, 111340.
• MacGowan G, Woods A, Robinson-Smith N, Tovey S, Bouzas-Cruz N, Gonzalez-Fernandez O, McDiarmid A, Parry G, O'Leary D, Schueler S. Using Existing Technology Better: Improving Outcomes with the HeartWare Left Ventricular Assist Device. International Journal of Cardiology 2021, 331, 35-39.
• Okwose NC, Bouzas-Cruz N, Fernandez OG, Koshy A, Green T, Woods A, Robinson-Smith N, Tovey S, Mcdiarmid A, Parry G, Schueler S, Macgowan GA, Jakovljevic DG. Validity of Hemodynamic Monitoring Using Inert Gas Rebreathing Method in Patients With Chronic Heart Failure and Those Implanted With a Left Ventricular Assist Device. Journal of Cardiac Failure 2021, 27(4), 414-418.
• Sengupta SP, Mungulmare K, Okwose NC, MacGowan GA, Jakovljevic DG. Comparison of cardiac output estimates by echocardiography and bioreactance at rest and peak dobutamine stress test in heart failure patients with preserved ejection fraction. Echocardiography 2020, 37(10), 1603-1609.
• Tafelmeier M, Baessler A, Wagner S, Unsoeld B, Preveden A, Barlocco F, Tomberli A, Popovic D, Brennan P, MacGowan GA, Ristic A, Velicki L, Olivotto I, Jakovljevic DG, Maier LS. Design of the SILICOFCM study: Effect of sacubitril/valsartan vs lifestyle intervention on functional capacity in patients with hypertrophic cardiomyopathy. Clinical Cardiology 2020, 43(5), 430-440.
• Wang L, MacGowan GA, Ali S, Dark JH. Ex situ heart perfusion: The past, the present, and the future. Journal of Heart and Lung Transplantation 2020, 40(1), 69-86.
• Velicki L, Jakovljevic DG, Preveden A, Golubovic M, Bjelobrk M, Ilic A, Stojsic S, Barlocco F, Tafelmeier M, Okwose N, Tesic M, Brennan P, Popovic D, Ristic A, MacGowan GA, Filipovic N, Maier LS, Olivotto I. Genetic determinants of clinical phenotype in hypertrophic cardiomyopathy. BMC Cardiovascular Disorders 2020, 20(1), 516.
• Okwose NC, O'Brien N, Charman S, Cassidy S, Brodie D, Bailey K, Macgowan GA, Jakovljevic DG, Avery L. Overcoming barriers to engagement and adherence to a home-based physical activity intervention for patients with heart failure: A qualitative focus group study. BMJ Open 2020, 10(9), e036382.
• Rushton S, Parameshwar J, Lim S, Dar O, Callan P, Al-Attar N, Tsui S, MacGowan GA. The introduction of a super-urgent heart allocation scheme in the UK: a two-year review. Journal of Heart and Lung Transplantation 2020, 39(10), 1109-1117.
• Bourke JP, Guglieri M, Duboc D, Aartsma-Rus A, Bandali A, Bennett N, Cools B, Cripe L, de Groot I, Dittrich S, Florian A, Furlong P, Goemans N, Hor K, van Leperen F, MacGowan G, McNally E, Pegoraro E, Politano L, Sediva M, Stara V, Timmermans J, Vroom E, Wahbi K. 238th ENMC International Workshop: Updating management recommendations of cardiac dystrophinopathyHoofddorp, The Netherlands, 30 November - 2 December 2018. In: Neuromuscular Disorders. 2019, Hoofddorp, The Netherlands: Elsevier Ltd.
• Okwose NC, Avery L, O'Brien N, Cassidy S, Charman SJ, Bailey K, Velicki L, Olivotto I, Brennan P, MacGowan GA, Jakovljevic DG. Acceptability, Feasibility and Preliminary Evaluation of a Novel, Personalised, Home-Based Physical Activity Intervention for Chronic Heart Failure (Active-at-Home-HF): a Pilot Study. Sports Medicine Open 2019, 5, 45.
• Koshy A, Okwose NC, Nunan D, Toms A, Brodie DA, Doherty P, Seferovic P, Ristic A, Velicki L, Filipovic N, Popovic D, Skinner J, Bailey K, MacGowan GA, Jakovljevic DG. Association between heart rate variability and haemodynamic response to exercise in chronic heart failure. Scandinavian Cardiovascular Journal 2019, 53(2), 77-82.
• Jones C, Markovic M, Charman S, Okwose N, Ivkovic S, Ropret R, Markovic B, Mandaric S, Grbovic M, MacGowan GA, Jakovljevic DG. Cardiac function is not associated with glucose control in older women. Experimental Gerontology 2019, 116, 31-36.
• Gonzalez-Fernandez O, Bouzas-Cruz N, Ferrera C, Woods A, Robinson-Smith N, Tovey S, Parry G, MacGowan GA, Schueler S. Effect of Preoperative Tricuspid and/or Mitral Regurgitation on Development of Late Right-Sided Heart Failure After Insertion of the HeartWare Left Ventricular Assist Device. American Journal of Cardiology 2019, 125(2), 236-243.
• MacGowan GA, Dark JH, Corris PA, Nair AR. Effects of drug abuse, smoking and alcohol on donor hearts and lungs. Transplant International 2019, 32(10), 1019-1027.
• MacGowan GA, Jakovljevic DG. Exercise Hemodynamics to Evaluate the Breathless Patient: Defining the Normal Pulmonary Arterial Wedge Pressure. Journal of Cardiac Failure 2019, 25(2), 123-124.
• Suryanegara J, Cassidy S, Ninkovic V, Popovic D, Grbovic M, Okwose N, Trenell MI, MacGowan GG, Jakovljevic DG. High intensity interval training protects the heart during increased metabolic demand in patients with type 2 diabetes: a randomised controlled trial. Acta Diabetologica 2019, 56(3), 321-329.
• Bouzas-Cruz N, Gonzalez-Fernandez O, Ferrera-Duran C, Woods A, Robinson-Smith N, Tovey S, Jungschleger J, Booth K, Shah A, Parry G, MacGowan GA, Schueler S. Initial conservative management strategy of HeartWare left ventricular assist device thrombosis with intravenous heparin or bivalirudin. International Journal of Artificial Organs 2019, 43(7), 444-451.
• Koshy A, Cruz NB, Okwose NC, Fernandez OG, Green T, Woods A, Robinson-Smith N, Tovey S, McDiarmid A, Parry G, Schueler S, Jakovljevic DG, MacGowan GA. Left Ventricular Filling Pressures Contribute to Exercise Limitation in Patients with Continuous Flow Left Ventricular Assist Devices. ASAIO Journal 2019, 66(3), 247-252.
• Ferrera C, Gonzalez Fernandez O, Bouzas N, Castrodeza J, Green T, Woods A, Robinson-Smith N, Tovey S, Jakovljevic DG, Shah A, Booth K, Parry G, Schueler S, MacGowan GA. Neutrophil to Lymphocyte Ratio Is Related to Thrombotic Complications and Survival in Continuous Flow Left Ventricular Assist Devices. ASAIO Journal 2019, 66(2), 199-204.
• Parovic M, Okwose NC, Bailey K, Velicki L, Seferovic PM, MacGowan GA, Jakovljevic DG. NT-proBNP is a weak indicator of cardiac function and haemodynamic response to exercise in chronic heart failure. ESC Heart Failure 2019, 6(2), 449-454.
• Charman S, Okwose N, Maniatopoulos G, Graziadio S, Metzler T, Banks H, Vale L, MacGowan GA, Seferovic PM, Fuat A, Deaton C, Mant J, Hobbs RFD, Jakovljevic DG. Opportunities and challenges of a novel cardiac output response to stress (CORS) test to enhance diagnosis of heart failure in primary care: Qualitative study. BMJ Open 2019, 9(4), e028122.
• Crossland DS, Jansen K, Parry G, Harper A, Perri G, Davidson A, De Rita F, Hermuzi A, Nassar M, Seller N, MacGowan GA, Hasan A, O'Sullivan JJ, Coats L. Outcome following heart transplant assessment in adults with congenital heart disease. Heart 2019, 105(2), 1741-1747.
• Parameshwar J, Hogg R, Rushton S, Taylor R, Shaw S, Mehew J, Simon A, Macgowan GA, Dalzell JR, Al Attar N, Venkateswaran R, Lim HS, Schueler S, Tsui S, Banner NR. Patient survival and therapeutic outcome in the UK bridge to transplant left ventricular assist device population. Heart 2019, 105(4), 291-296.
• Okwose NC, Zhang J, Chowdhury S, Houghton D, Ninkovic S, Jakovljevic S, Jevtic B, Ropret R, Eggett C, Bates M, MacGowan G, Jakovljevic D. Reproducibility of Inert Gas Rebreathing Method to Estimate Cardiac Output at Rest and During Cardiopulmonary Exercise Stress Testing. International Journal of Sports Medicine 2019, 40(2), 125-132.
• Koshy A, Green T, Toms A, Cassidy S, Schueler S, Jakovljevic D, MacGowan GA. The role of exercise hemodynamics in assessing patients with chronic heart failure and left ventricular assist devices. Expert Review of Medical Devices 2019, 16(10), 891-898.
• Standing HC, Exley C, MacGowan GA, Rapley T. ‘We’re like a gang, we stick together’: experiences of ventricular assist device communities. European Journal of Cardiovascular Nursing 2018, 17(5), 339-407.
• Charman SJ, Okwose NC, Stefanetti RJ, Bailey K, Skinner J, Ristic A, Seferovic PM, Scott M, Turley S, Fuat A, Mant J, Hobbs FDR, MacGowan GA, Jakovljevic DG. A novel cardiac output response to stress test developed to improve diagnosis and monitoring of heart failure in primary care. ESC Heart Failure 2018, 5(4), 703-712.
• Okwose NC, Chowdhury S, Houghton D, Trenell MI, Eggett C, Bates M, Macgowan GA, Jakovljevic DG. Comparison of cardiac output estimates by bioreactance and inert gas rebreathing methods during cardiopulmonary exercise testing. Clinical Physiology and Functional Imaging 2018, 38(3), 483-490.
• Urban M, Woods A, Robinson-Smith N, MacGowan G, Roysam C, Schueler S. First-in-man use of the MVAD axial-flow pump: Long-term outcome. Journal of Heart and Lung Transplantation 2018, 37(7), 933-936.
• Nathania M, Hollingsworth KG, Bates M, Eggett C, Trenell MI, Velicki L, Seferovic PM, MacGowan GA, Turnbull DM, Jakovljevic DG. Impact of age on the association between cardiac high-energy phosphate metabolism and cardiac power in women. Heart 2018, 104(2), 111-118.
• Blain AM, Greally E, McClorey G, Manzano R, Betts CA, Godfrey C, O'Donovan L, Coursindel T, Gait MJ, Wood MJ, MacGowan GA, Straub VW. Peptide-conjugated phosphodiamidate oligomer-mediated exon skipping has benefits for cardiac function in mdx and Cmah-/-mdx mouse models of Duchenne muscular dystrophy. PLoS ONE 2018, 13(6), e0198897.
• Cassidy S, Vaidya V, Houghton D, Zalewski P, Seferovic JP, Hallsworth K, MacGowan GA, Trenell MI, Jakovljevic DG. Unsupervised high-intensity interval training improves glycaemic control but not cardiovascular autonomic function in type 2 diabetes patients: A randomised controlled trial. Diabetes and Vascular Disease Research 2018, 16(1), 69-76.
• Standing HC, Rapley T, MacGowan GA, Exley C. ‘Being’ a ventricular assist device recipient: A liminal existence. Social Science and Medicine 2017, 190, 141-148.
• MacGowan GA, Parikh JD, Hollingsworth KG. Diffusion Tensor Magnetic Resonance Imaging of the Heart: Looking Into the Layers of the Myocardium. Journal of the American College of Cardiology 2017, 69, 677-678.
• Tomas C, Finkelmeyer A, Hodgson T, MacLachlan L, MacGowan GA, Blamire AM, Newton JL. Elevated brain natriuretic peptide levels in chronic fatigue syndrome associate with cardiac dysfunction: a case control study. Open Heart 2017, 4(2), e000697.
• Kasouridis I, Majo J, MacGowan G, Clark AL. Giant cell myocarditis presenting with acute heart failure. BMJ Case Reports 2017, 2017.
• Dobarro D, Urban M, Booth K, Wrightson N, Castrodeza J, Jungschleger J, Robinson-Smith N, Woods A, Parry G, Schueler S, MacGowan GA. Impact of aortic valve closure on adverse events and outcomes with the HeartWare ventricular assist device. Journal of Heart and Lung Transplantation 2017, 36(1), 42-49.
• Jakovljevic DG, Yacoub MH, Schueler S, MacGowan AG, Velicki L, Seferovic PM, Hothi S, Tzeng BT, Brodie DA, Birks EJ, Tan LB. Left Ventricular Assist Device as a Bridge to Recovery for Patients With Advanced Heart Failure. Journal of the American College of Cardiology 2017, 69(15), 1924-1933.
• Parikh JD, Hollingsworth KG, Wallace D, Blamire AM, MacGowan GA. Left ventricular functional, structural and energetic effects of normal aging: Comparison with hypertension. Plos One 2017, 12(5), e0177404.
• MacGowan GA, Wrightson N, Robinson-Smith N, Woods A, Parry G, Gould K, Schueler S. Myocardial Recovery Strategy with Decommissioning for the HeartWare Left Ventricular Assist Device. ASAIO Journal 2017, 63(3), 299-304.
• McCoy J, Bates M, Eggett C, Siervo M, Cassidy S, Newman J, Moore SA, Gorman G, Trenell MI, Velicki L, Seferovic PM, Cleland JGF, MacGowan GA, Turnbull DM, Jakovljevic DG. Pathophysiology of exercise intolerance in chronic diseases: the role of diminished cardiac performance in mitochondrial and heart failure patients. Open Heart 2017, 4, e000632.
• Njemanze H, Warren C, Eggett C, MacGowan GA, Bates MGD, Siervo M, Ivkovic S, Trenell MI, Jakovljevic DG. Age-related decline in cardiac autonomic function is not attenuated with increased physical activity. Oncotarget 2016, 7(47), 76390-76397.
• Peng E, Kirk R, Wrightson N, Duong P, Ferguson L, Griselli M, Butt T, O'Sullivan JJ, MacGowan GA, Crossland D, Schueler S, Hasan A. An Extended Role of Continuous Flow Device in Pediatric Mechanical Circulatory Support. Annals of Thoracic Surgery 2016, 102(2), 620-627.
• Bhagra S, Bhagra C, Ozalp F, Butt T, Ramesh BC, Parry G, Roysam C, Woods A, Robinson-Smith N, Wrightson N, MacGowan GA, Schueler S. Development of de novo aortic valve incompetence in patients with the continuous-flow HeartWare ventricular assist device. The Journal of Heart and Lung Transplantation 2016, 35(3), 312-319.
• Parikh JD, Hollingsworth KG, Kunadian V, Blamire AM, MacGowan GA. Measurement of pulse wave velocity in normal ageing: comparison of Vicorder and magnetic resonance phase contrast imaging. BMC Cardiovascular Disorders 2016, 16, 50.
• Parikh J, Hollingsworth KG, Wallace D, Blamire AM, MacGowan GA. Normal age-related changes in left ventricular function: Role of afterload and subendocardial dysfunction. International Journal of Cardiology 2016, 223, 306-312.
• Bhagra CJ, Bhagra SK, Donado A, Butt T, Forrest L, MacGowan GA, Parry G. Pregnancy in cardiac transplant recipients. Clinical Transplantation 2016, 30(9), 1059-1065.
• Newton JL, Finkelmeyer A, Petrides G, Frith J, Hodgson T, Maclachlan L, MacGowan G, Blamire AM. Reduced cardiac volumes in chronic fatigue syndrome associate with plasma volume but not length of disease: a cohort study. Open Heart 2016, 3(1), e000381.
• Perkins RE, Hollingsworth KG, Eggett C, MacGowan GA, Bates MG, Trenell MI, Jakovljevic DG. Relationship between bioreactance and magnetic resonance imaging stroke volumes. British Journal of Anaesthesia 2016, 117(1), 134-136.
• MacGowan GA. The Challenge of Radiation-Induced Restrictive Cardiomyopathy and Outcomes After Heart Transplantation. Journal of Cardiac Failure 2016, 22(6), 479-480.
• Houghton D, Jones TW, Cassidy S, Siervo M, MacGowan GA, Trenell MI, Jakovljevic DG. The effect of age on the relationship between cardiac and vascular function. Mechanisms of Ageing and Development 2016, 153, 1-6.
• Blain A, Greally E, Laval SH, Blamire AM, MacGowan GA, Straub VW. Absence of Cardiac Benefit with Early Combination ACE Inhibitor and Beta Blocker Treatment in mdx Mice. Journal of Cardiovascular Translational Research 2015, 8(3), 198-207.
• Blain AM, Greally E, Laval SH, Blamire AM, MacGowan GA, Straub VW. Assessment of ventricular function in mouse models of muscular dystrophy: A comparison of MRI with conductance catheter. Neuromuscular Disorders 2015, 25(1), 24-31.
• Jones T, Houghton D, Cassidy S, MacGowan GA, Trenell MI, Jakovljevic DG. Bioreactance is a reliable method for estimating cardiac output at rest and during exercise. British Journal of Anaesthesia 2015, 115(3), 386-391.
• Cassidy S, Hallsworth K, Thoma C, MacGowan GA, Hollingsworth KG, Day CP, Taylor R, Jakovljevic DG, Trenell MI. Cardiac structure and function are altered in type 2 diabetes and Non-alcoholic fatty liver disease and associate with glycemic control. Cardiovascular Diabetology 2015, 14, 23.
• MacGowan GA, Crossland DS, Hasan A, Schueler S. Considerations for patients awaiting heart transplantation-Insights from the UK experience. Journal of Thoracic Disease 2015, 7(3), 527-531.
• Jakovljevic DG, Papakonstantinou L, Blamire AM, MacGowan GA, Taylor R, Hollingsworth KG, Trenell MI. Effect of Physical Activity on Age-Related Changes in Cardiac Function and Performance in Women. Circulation: Cardiovascular Imaging 2015, 8, e002086.
• Fazal IA, Bhagra SK, Bailey KM, Neely RD, MacGowan GA, Skinner JS. Impact of using different guideline recommended serum natriuretic peptide thresholds on the diagnosis and referral rates of a diagnostic heart failure clinic. International Journal of Clinical Practice 2015, 69(11), 1349-1356.
• Bhagra SK, Bhagra CJ, Wrightson N, MacGowan GA, Schueler S. Long Term Measurements of Aortic Root and Left Ventricular Dimensions in Patients on HeartWare® Ventricular Assist Device - An Explanation for the Development of Aortic Incompetence in Chronic LVAD Support?. In: 35th Annual Meeting of the International Society for Heart and Lung Transplantation. 2015, Nice, France: Elsevier.
• Veerasamy M, Ford GA, Neely D, Bagnall A, Macgowan G, Das R, Kunadian V. Association of Aging, Arterial Stiffness and Cardiovascular Disease: A Review. Cardiology in Review 2014, 22(5), 223-232.
• Jakovljevic DG, Trenell MI, MacGowan GA. Bioimpedance and bioreactance methods for monitoring cardiac output. Best Practice & Research Clinical Anaesthesiology 2014, 28(4), 381-394.
• Jakovljevic DG, Trenell MI, MacGowan GA. Bioimpedance and bioreactance methods for monitoring cardiac output. Best Practice & Research: Clinical Anaesthesiology 2014, 28(4), 381-394.
• Peng E, O'Sullivan JJ, Griselli M, Roysam C, Crossland D, Chaudhari M, Wrightson N, Butt T, Parry G, MacGowan GA, Schueler S, Hasan A. Durable Ventricular Assist Device Support for Failing Systemic Morphologic Right Ventricle: Early Results. Annals of Thoracic Surgery 2014, 98(6), 2122-2129.
• Jakovljevic DG, McDiarmid A, Hallsworth K, Seferovic PM, Ninkovic VM, Parry G, Schueler S, Trenell MI, MacGowan GA. Effect of Left Ventricular Assist Device Implantation and Heart Transplantation on Habitual Physical Activity and Quality of Life. American Journal of Cardiology 2014, 114(1), 88-93.
• Jakovljevic DG, Papakonstantinou L, Blamire AM, MacGowan GA, Taylor R, Hollingsworth KG, Trenell MI. Effect of physical activity on age-related changes in cardiac function and performance in women. Circulation: Cardiovascular Imaging 2014, 8(1), e002086.
• Jakovljevic DG, Papakonstantinou L, Blamire AM, MacGowan GA, Taylor R, Hollingsworth KG, Trenell MI. Effect of physical activity on age-related changes in cardiac function and performance in women. Circulation: Cardiovascular Imaging 2014.
• Ozalp F, Bhagra S, Bhagra C, Butt T, Ramesh B, Robinson-Smith N, Wrightson N, Parry G, Griselli M, Hasan A, Schueler S, MacGowan GA. Four-year outcomes with third-generation centrifugal left ventricular assist devices in an era of restricted transplantation. European Journal of Cardio-Thoracic Surgery 2014, 46(3), e35-e40.
• Stehlik J, Stevenson LW, Edwards LB, Crespo-Leiro MG, Delgado JF, Dorent R, Frigerio M, Macdonald P, MacGowan GA, Costa AN, Rogers JG, Shah AS, Taylor R, Venkateswaran RV, Mehra MR. Organ Allocation Around the World: Insights From the ISHLT International Registry for Heart and Lung Transplantation. Journal of Heart and Lung Transplantation 2014, 33(10), 975-984.
• Collerton J, Kingston A, Yousaf F, Davies K, Kenny A, Neely D, Martin-Ruiz C, MacGowan G, Robinson L, Kirkwood TBL, Keavney B. Utility of NT-proBNP as a rule-out test for left ventricular dysfunction in very old people with limiting dyspnoea: the Newcastle 85+Study. BMC Cardiovascular Disorders 2014, 14, 128.
• Blain A, Greally E, Laval S, Blamire A, Straub V, MacGowan GA. Beta-Blockers, Left and Right Ventricular Function, and In-Vivo Calcium Influx in Muscular Dystrophy Cardiomyopathy. PLoS One 2013, 8(2), e57260.
• Hallsworth K, Hollingsworth KG, Thoma C, Jakovljevic DG, MacGowan GA, Anstee QM, Taylor R, Day CP, Trenell MI. Cardiac structure and function are altered in adults with non-alcoholic fatty liver disease. Journal of Hepatology 2013, 58(4), 757-762.
• Bates MG, Hollingsworth KG, Newman J, Jakovljevic DG, Blamire AM, MacGowan GA, Keavney BD, Chinnery PF, Turnbull DM, Taylor RW, Trenell MI, Gorman GS. Concentric hypertrophic remodeling and subendocardial dysfunction in mitochondrial DNA point mutation carriers. European Heart Journal - Cardiovascular Imaging 2013, 14(7), 650-658.
• Bates MG, Newman JH, Jakovljevic DG, Hollingsworth KG, Alston CL, Zalewski P, Klawe JJ, Blamire AM, Macgowan GA, Keavney BD, Bourke JP, Schaefer A, McFarland R, Newton JL, Turnbull DM, Taylor RW, Trenell MI, Gorman GS. Defining cardiac adaptations and safety of endurance training in patients with m.3243A>g-related mitochondrial disease. International Journal of Cardiology 2013, 168(4), 3599-3608.
• McDiarmid A, Gordon B, Wrightson N, Robinson-Smith N, Pillay T, Parry G, Schueler S, MacGowan GA. Hemodynamic, Echocardiographic, and Exercise-Related Effects of the HeartWare Left Ventricular Assist Device in Advanced Heart Failure. Congestive Heart Failure 2013, 19(1), 11-15.
• Greally E, Davison BJ, Blain A, Laval S, Blamire A, Straub V, MacGowan GA. Heterogeneous abnormalities of in-vivo left ventricular calcium influx and function in mouse models of muscular dystrophy cardiomyopathy. Journal of Cardiovascular Magnetic Resonance 2013, 15, 4.
• Patangi SO, George A, Pauli H, O'Leary D, Roysam C, Butt T, Schueler S, Prabhu M, MacGowan G. Management issues during HeartWare left ventricular assist device implantation and the role of transesophageal echocardiography. Annals of Cardiac Anaesthesia 2013, 16(4), 259-267.
• Hollingsworth KG, Willis TA, Bates MG, Dixon BJ, Lochmüller H, Bushby K, Bourke J, MacGowan GA, Straub V. Subepicardial dysfunction leads to global left ventricular systolic impairment in patients with limb girdle muscular dystrophy 2I. European Journal of Heart Failure 2013, 15(9), 986-994.
• Emin A, Rogers CA, Parameshwar J, MacGowan G, Taylor R, Yonan N, Simon A, Tsui S, Schueler S, Banner NR. Trends in long-term mechanical circulatory support for advanced heart failure in the UK. European Journal of Heart Failure 2013, 15(10), 1185-1193.
• MacGowan GA, Parry G, Hasan A, Schueler S. Ventricular assist devices for advanced heart failure: evidence that cannot be ignored. European Journal of Cardio-Thoracic Surgery 2013, 43(6), 1242-1243.
• Blain A, Greally E, Laval S, Blamire A, MacGowan G, Straub V. Animal Models of Duchenne Muscular Dystrophy, with Special Reference to the mdx Mouse. Biocybernetics and Biomedical Engineering 2012, 32(4), 3-15.
• Hollingsworth KG, Macgowan GA, Morris L, Bates MG, Taylor R, Jones DE, Newton JL, Blamire AM. Cardiac torsion-strain relationships in fatigued primary biliary cirrhosis patients show accelerated aging: a pilot cross-sectional study. Journal of Applied Physiology 2012, 112(12), 2043-2048.
• Hollingsworth KG, Gorman GS, Trenell MI, McFarland R, Taylor RW, Turnbull DM, Macgowan GA, Blamire AM, Chinnery PF. Cardiomyopathy is common in patients with the mitochondrial DNA m.3243A>G mutation and correlates with mutation load. Neuromuscular Disorders 2012, 22(7), 592-596.
• Hollingsworth KG, Hodgson T, MacGowan GA, Blamire AM, Newton JL. Impaired cardiac function in chronic fatigue syndrome measured using magnetic resonance cardiac tagging. Journal of Internal Medicine 2012, 271(3), 264-270.
• Hollingsworth KG, Blamire AM, Keavney BD, MacGowan GA. Left ventricular torsion, energetics, and diastolic function in normal human aging. American Journal of Physiology: Heart and Circulatory Physiology 2012, 302(4), H885-H892.
• MacGowan GA, Schueler S. Right heart failure after left ventricular assist device implantation: early and late. Current Opinion in Cardiology 2012, 27(3), 296-300.
• Jørgensen LH, Blain A, Greally E, Laval SH, Blamire AM, Davison BJ, Brinkmeier H, Macgowan GA, Schrøder HD, Bushby K, Straub V, Lochmüller H. Long-Term Blocking of Calcium Channels in mdx Mice Results in Differential Effects on Heart and Skeletal Muscle. American Journal of Pathology 2011, 178(1), 273-283.
• Macgowan GA, Parry G, Schueler S, Hasan A. The decline in heart transplantation in the UK. British Medical Journal 2011, 342, d2483.
• Bauer R, Blain A, Greally E, Lochmuller H, Bushby K, MacGowan GA, Straub V. Attenuation of adverse cardiac effects in prednisolone-treated delta-sarcoglycan-deficient mice by mineralocorticoid-receptor-antagonism. Neuromuscular Disorders 2010, 20(1), 21-28.
• Langley P, MacGowan GA, Murray A. Circadian variation of human ventricular fibrillation dominant frequency. Resuscitation 2010, 81(8), 950-955.
• MacGowan GA, Neely D, Peaston R, Wrightson N, Parry G. Evaluation of NT-proBNP to predict outcomes in advanced heart failure. International Journal of Clinical Practice 2010, 64(7), 892-899.
• Jones DEJ, Hollingsworth K, Fattakhova G, MacGowan G, Taylor R, Blamire A, Newton JL. Impaired cardiovascular function in primary biliary cirrhosis. American Journal of Physiology: Gastrointestinal and Liver Physiology 2010, 298(5), G764-G773.
• Bauer R, Blain A, Greally E, Bushby K, Lochmuller H, Laval S, Straub V, MacGowan GA. Intolerance to beta-blockade in a mouse model of delta-sarcoglycan-deficient muscular dystrophy cardiomyopathy. European Journal of Heart Failure 2010, 12(11), 1163-1170.
• Botha P, MacGowan GA, Dark JH. Sildenafil Citrate Augments Myocardial Protection in Heart Transplantation. Transplantation 2010, 89(2), 169-177.
• Botha P, Parry G, Dark JH, MacGowan GA. Acute hemodynamic effects of intravenous sildenafil citrate in congestive heart failure: comparison of phosphodiesterase type-3 and -5 inhibition. Journal of Heart and Lung Transplantation 2009, 28, 676-82.
• Bauer R, Straub V, Blain A, Bushby K, MacGowan GA. Contrasting effects of steroids and angiotensin-converting-enzyme inhibitors in a mouse model of dystrophin-deficient cardiomyopathy. European Journal of Heart Failure 2009, 11(5), 463-471.
• MacGowan GA. Good news for mice with heart attacks: preventing acute myocardial injury by inhibiting apoptosis. Cardiovascular Research 2009, 81, 1-2.
• Kirk JA, MacGowan GA, Evans C, Smith SH, Warren CM, Mamidi R, Chandra M, Stewart AF, Solaro RJ, Shroff SG. Left ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I. Circulation Research 2009, 105, 1232-9.
• Langley P, MacGowan GA, Murray A. Spatial and temporal organization of the dominant frequencies in the fibrillating heart: body surface potential mapping in a rare case of sustained human ventricular fibrillation. Europace 2009, 11(3), 324-327.
• Bauer R, MacGowan GA, Blain A, Bushby K, Straub V. Steroid treatment causes deterioration of myocardial function in the δ-sarcoglycan-deficient mouse model for dilated cardiomyopathy. Cardiovascular Research 2008, 79(4), 652-661.
• MacGowan GA, Pohwani A, Murali S. Dynamic analysis of exercise oxygen consumption predicts outcomes in advanced heart failure. Congestive Heart Failure 2007, 13(6), 313-318.
• Botha P, Parry G, Dark JH, MacGowan GA. Intravenous sildenafil citrate for selective pulmonary vasodilatation in heart failure. Journal of Heart and Lung Transplantation 2007, 26(2), S133-S134.
• MacGowan GA, Kirk JA, Evans C, Shroff SG. Pressure-calcium relationships in perfused mouse hearts. American Journal of Physiology: Heart and Circulatory Physiology 2006, 290(6), H2614-H2624.
• MacGowan GA, Rager J, Shroff SG, Mathier MA. In vivo α-adrenergic responses and troponin I phosphorylation: Anesthesia interactions. Journal of Applied Physiology 2005, 98(4), 1163-1170.
• MacGowan GA. The myofilament force-calcium relationship as a target for positive inotropic therapy in congestive heart failure. Cardiovascular Drugs and Therapy 2005, 19(3), 203-210.
• MacGowan GA. What is the in vivo mechanism of action of levosimendan? [1]. Journal of Cardiac Failure 2005, 11(6), 482.
• Du C, Pan Y, MacGowan GA, Koretsky AP. Decreasing motion artifacts in calcium-dependent fluorescence transients from the perfused mouse heart using frequency filtering. Cell Calcium 2004, 35(2), 141-153.
• McNamara DM, Holubkov R, Postava L, Janosko K, MacGowan GA, Mathier M, Murali S, Feldman AM, London B. Pharmacogenetic interactions between angiotensin-converting enzyme inhibitor therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure. Journal of the American College of Cardiology 2004, 44(10), 2019-2026.
• MacGowan GA, Evans C, Hu TCC, Debrah D, Mullet S, Chen HH, McTiernan CF, Stewart AFR, Koretsky AP, Shroff SG. Troponin I protein kinase C phosphorylation sites and ventricular function. Cardiovascular Research 2004, 63(2), 245-255.
• McNamara DM, Holubkov R, Postava L, Ramani R, Janosko K, Mathier M, MacGowan GA, Murali S, Feldman AM, London B. Effect of the Asp298 variant of endothelial nitric oxide synthase on survival for patients with congestive heart failure. Circulation 2003, 107(2), 1598-1602.
• Pohwani AL, Murali S, Mathier MM, Tokarczyk T, Kormos RL, McNamara DM, MacGowan GA. Impact of beta-blocker therapy on functional capacity criteria for heart transplant listing. Journal of Heart and Lung Transplantation 2003, 22(1), 78-86.
• Du C, MacGowan GA, Farkas DL, Koretsky AP. Calcium measurements in perfused mouse heart: quantitating fluorescence and absorbance of Rhod-2 by application of photon migration theory. Biophysical Journal 2001, 80(1), 549-561.
• Du C, MacGowan GA, Farkas DL, Koretsky AP. Calibration of the calcium dissociation constant of Rhod(2)in the perfused mouse heart using manganese quenching. Cell Calcium 2001, 29(4), 217-227.
• MacGowan GA, Du C, Wieczorek DF, Koretsky AP. Compensatory changes in Ca(2+) and myocardial O(2) consumption in beta-tropomyosin transgenic hearts. American Journal of Physiology: Heart and Circulatory Physiology 2001, 281(6), 2539-2548.
• MacGowan GA, Panzak G, Murali S. Exercise-related ventilatory abnormalities are more specific for functional impairment in chronic heart failure than reduction in peak exercise oxygen consumption. Journal of Heart and Lung Transplantation 2001, 20(11), 1167-1173.
• MacGowan GA, Du C, Koretsky AP. High calcium and dobutamine positive inotropy in the perfused mouse heart: myofilament calcium responsiveness, energetic economy, and effects of protein kinase C inhibition. BMC Physiology 2001, 1, 12.
• MacGowan GA, Du C, Cowan DB, Stamm C, McGowan FX, Solaro RJ, Koretsky AP, Del Nido PJ. Ischemic dysfunction in transgenic mice expressing troponin I lacking protein kinase C phosphorylation sites. American Journal of Physiology: Heart and Circulatory Physiology 2001, 280(2), 835-843.
• Hu TC, Pautler RG, MacGowan GA, Koretsky AP. Manganese-enhanced MRI of mouse heart during changes in inotropy. Magnetic Resonance in Medicine 2001, 46(5), 884-890.
• McNamara DM, Holubkov R, Janosko K, Palmer A, Wang JJ, MacGowan GA, Murali S, Rosenblum WD, London B, Feldman AM. Pharmacogenetic Interactions Between β-Blocker Therapy and the Angiotensin-Converting Enzyme Deletion Polymorphism in Patients With Congestive Heart Failure. Circulation 2001, 103(12), 1644-1648.
• MacGowan GA, Du C, Glonty V, Suhan JP, Koretsky AP, Farkas DL. Rhod-2 based measurements of intracellular calcium in the perfused mouse heart: cellular and subcellular localization and response to positive inotropy. Journal of Biomedical Optics 2001, 6(1), 23.
• MacGowan GA, Koretsky AP. Inotropic and energetic effects of altering the force-calcium relationship: mechanisms, experimental results, and potential molecular targets. Journal of Cardiac Failure 2000, 6(2), 144-156.
• MacGowan GA, Haber HL, Cowart TD, Tedesco C, Wu C, Feldman MD. Direct myocardial effects of OPC-18790 in human heart failure: beneficial effects on contractile and diastolic function demonstrated by intracoronary infusion with pressure-volume analysis. J Am Coll Cardiol 1998.
• MacGowan GA, Mann DL, Kormos RL, Feldman AM, Murali S. Circulating interleukin-6 in severe heart failure. Am J Cardiol 1997.
• MacGowan GA, Janosko K, Cecchetti A, Murali S. Exercise-related ventilatory abnormalities and survival in congestive heart failure. Am J Cardiol 1997.
• MacGowan GA, Shapiro EP, Azhari H, Siu CO, Hees PS, Hutchins GM, Weiss JL, Rademakers FE. Noninvasive measurement of shortening in the fiber and cross-fiber directions in the normal human left ventricle and in idiopathic dilated cardiomyopathy. Circulation 1997.
• MacGowan GA, Burkhoff D, Rogers WJ, Salvador D, Azhari H, Hees PS, Zweier JL, Halperin HR, Siu CO, Lima JA, Weiss JL, Shapiro EP. Effects of afterload on regional left ventricular torsion. Cardiovasc Res 1996.