BGM2056 : DNA Replication, recombination and Repair
- Offered for Year: 2025/26
- Available to incoming Study Abroad and Exchange students
- Module Leader(s): Dr Laura Maringele
- Lecturer: Professor Heath Murray
- Owning School: Biomedical, Nutritional and Sports Scien
- Teaching Location: Newcastle City Campus
Semesters
Your programme is made up of credits, the total differs on programme to programme.
| Semester 2 Credit Value: | 10 |
| ECTS Credits: | 5.0 |
| European Credit Transfer System | |
Aims
1. To provide a sound understanding of the molecular mechanisms underlying the replication, repair and recombination of DNA and to demonstrate the unique importance of the accuracy of these processes.
2. To provide a framework for understanding the different types of DNA damage, the mechanisms by which they are repaired and the diseases that result from defects in these repair processes.
Outline Of Syllabus
This module provides an understanding of the following key DNA-dependent processes:
- accurate replication of the genome
- recombination, mechanisms of genetic variation
- repair of DNA damage
- results of failure to correct DNA damage (e.g. mutation, genetic instability, cancer).
development of genetic diseases (e.g. developmental disorders, cancer predisposition and premature ageing)
Teaching Methods
Teaching Activities
| Category | Activity | Number | Length | Student Hours | Comment |
|---|---|---|---|---|---|
| Scheduled Learning And Teaching Activities | Lecture | 1 | 1:00 | 1:00 | In person - Feedback and opportunity for queries |
| Scheduled Learning And Teaching Activities | Lecture | 12 | 1:00 | 12:00 | In person - Theory/themes/methodologies/techniques re DNA replication recombination & repair |
| Scheduled Learning And Teaching Activities | Practical | 1 | 5:00 | 5:00 | In person - Laboratory practical sessions. UV survival curves |
| Guided Independent Study | Independent study | 1 | 82:00 | 82:00 | Writing up lecture notes, revision and general reading |
| Total | 100:00 |
Teaching Rationale And Relationship
The lectures will be used to deliver theory, themes, methodologies and techniques relating to DNA replication, recombination and repair, and to reinforce the lecture material and allow feedback on the practical/data handling exercise.
These sessions will be reinforced by the material covered in the practical/data analysis sessions.
Assessment Methods
The format of resits will be determined by the Board of Examiners
Exams
| Description | Length | Semester | When Set | Percentage | Comment |
|---|---|---|---|---|---|
| Written Examination | 53 | 2 | A | 56 | PIP invigilated handwritten essay. One question from a choice of two & Inspera digital exam MCQ format max 30 questions. Part 1 Inspera, Part 2 written, exams to be scheduled together. Inspera to be open for duration of the examination (75 mins) |
| Digital Examination | 22 | 2 | A | 24 | PIP invigilated Inspera digital exam, MCQ format max 30 questions & invigilated written essay. One question from a choice of two. Part 1 Inspera, Part 2 written, exams to be scheduled together. Inspera to be open for duration of the exam- (75 mins) |
Other Assessment
| Description | Semester | When Set | Percentage | Comment |
|---|---|---|---|---|
| Practical/lab report | 2 | M | 20 | Experience gained in accurate recording & with determination of UV survival curves. All pre-set questions must be answered. |
Assessment Rationale And Relationship
The written exam will test the student’s knowledge and understanding of taught material and additional reading.
The practical report will test understanding of the material delivered, as well as providing training in key laboratory and numeracy skills.
Reading Lists
Timetable
- Timetable Website: www.ncl.ac.uk/timetable/
- BGM2056's Timetable