BGM2056 : DNA Replication, recombination and Repair
- Offered for Year: 2022/23
- Available to incoming Study Abroad and Exchange students
- Module Leader(s): Dr Simon Whitehall
- Lecturer: Professor Heath Murray
- Owning School: Biomedical, Nutritional and Sports Scien
- Teaching Location: Newcastle City Campus
Semesters
| Semester 2 Credit Value: | 10 |
| ECTS Credits: | 5.0 |
Aims
1. To provide a sound understanding of the molecular mechanisms underlying the replication, repair and recombination of DNA and to demonstrate the unique importance of the accuracy of these processes.
2. To provide a framework for understanding the different types of DNA damage, the mechanisms by which they are repaired and the diseases that result from defects in these repair processes.
Outline Of Syllabus
This module provides an understanding of the following key DNA-dependent processes:
- accurate replication of the genome
- recombination, mechanisms of genetic variation
- repair of DNA damage
- results of failure to correct DNA damage (e.g. mutation, genetic instability, cancer).
development of genetic diseases (e.g. developmental disorders, cancer predisposition and premature ageing)
Teaching Methods
Teaching Activities
| Category | Activity | Number | Length | Student Hours | Comment |
|---|---|---|---|---|---|
| Scheduled Learning And Teaching Activities | Lecture | 12 | 1:00 | 12:00 | PIP - Theory/themes/methodologies/techniques re DNA replication recombination & repair |
| Scheduled Learning And Teaching Activities | Lecture | 1 | 1:00 | 1:00 | PIP - Feedback and opportunity for queries |
| Scheduled Learning And Teaching Activities | Practical | 1 | 5:00 | 5:00 | PIP - Laboratory practical sessions. UV survival curves |
| Guided Independent Study | Independent study | 1 | 82:00 | 82:00 | Writing up lecture notes, revision and general reading |
| Total | 100:00 |
Teaching Rationale And Relationship
The lectures will be used to deliver theory, themes, methodologies and techniques relating to DNA replication, recombination and repair, and to reinforce the lecture material and allow feedback on the practical/data handling exercise.
These sessions will be reinforced by the material covered in the practical/data analysis sessions.
Assessment Methods
The format of resits will be determined by the Board of Examiners
Exams
| Description | Length | Semester | When Set | Percentage | Comment |
|---|---|---|---|---|---|
| Written Examination | 75 | 2 | A | 80 | Invigilated exam: Max of 30 MCQ questions (30% of the marks) and 1 essay from a choice of 2 (70% of the marks) |
Other Assessment
| Description | Semester | When Set | Percentage | Comment |
|---|---|---|---|---|
| Practical/lab report | 2 | M | 20 | Experience gained in accurate recording & with determination of UV survival curves. All pre-set questions must be answered. |
Assessment Rationale And Relationship
The practical report will test understanding of the material delivered, as well as providing training in key laboratory and numeracy skills.
Reading Lists
Timetable
- Timetable Website: www.ncl.ac.uk/timetable/
- BGM2056's Timetable